https://ogma.newcastle.edu.au/vital/access/manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:20501 Sat 24 Mar 2018 07:59:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:28682 n = 10), PT (n = 8) and control (n = 9). OGT and OGA mRNA levels were measured from muscle samples obtained at baseline and after one year. Knee extensor muscle cross-sectional area (CSA), knee extension force, running speed and vertical jumping height were measured. During the yearlong intervention, HRT suppressed the aging-associated upregulation of OGT mRNA that occurred in the controls. The effects of PT were similar but weaker. HRT also tended to increase the OGA mRNA level compared to the controls. The change in the ratio of OGT to OGA gene expressions correlated negatively with the change in muscle CSA. Our results suggest that OGT and OGA gene expressions are associated with muscle size during the critical postmenopausal period. HRT and PT influence muscle OGT and OGA gene expression, which may be one of the mechanisms by which HRT and PT prevent aging-related loss of muscle mass.]]> Sat 24 Mar 2018 07:30:08 AEDT ]]>