https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24073 -11). SNP rs727479 was also among those most strongly associated with circulating E₂ concentrations in 2767 post-menopausal controls (P=7.4x10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by the observed effect on E₂ concentrations (1.09, CI=1.03-1.21), consistent with the hypothesis that endometrial cancer risk is driven by E₂. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.]]> Wed 11 Apr 2018 16:40:46 AEST ]]> Deletion mutations in an Australian series of HNPCC patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:458 Wed 11 Apr 2018 15:11:16 AEST ]]> DNA and RNA analyses in detection of genetic predisposition to cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21177 Wed 11 Apr 2018 13:14:15 AEST ]]> Case report: familial gastric cancer and chordoma in the same family https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:600 Thu 25 Jul 2013 09:10:23 AEST ]]> Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:375 Thu 25 Jul 2013 09:10:05 AEST ]]> Comparison of genomic abnormalities between BRCAX and sporadic breast cancers studied by comparative genomic hybridization https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:261 Sat 24 Mar 2018 07:42:57 AEDT ]]>