https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Lipid and metabolite deregulation in BRCA1 and BRCA2 genetic mutations: response https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24236 Wed 16 Nov 2016 14:36:47 AEDT ]]> Hitchhiker's guide to voxel segmentation for partial volume correction of in vivo magnetic resonance spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24868 Wed 11 Apr 2018 16:46:08 AEST ]]> Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21288 in vivo Localized COrrelated SpectroscopY (L-COSY). Methods: To achieve this, L-COSY was used to examine five former professional male athletes with 11 to 28 years of exposure to contact sports. Each athlete who had had multiple symptomatic concussions and repetitive sub concussive trauma during their career was assessed by an experienced neuropsychologist. All athletes had clinical symptoms including headaches, memory loss, confusion, impaired judgment, impulse control problems, aggression, and depression. Five healthy men, age and weight matched to the athlete cohort and with no history of brain trauma, were recruited as controls. Data were collected from the posterior cingulate gyrus using a 3 T clinical magnetic resonance scanner equipped with a 32 channel head coil. Results: The variation of the method was calculated by repeated examination of a healthy control and phantom and found to be 10% and 5%, respectively, or less. The L-COSY measured large and statistically significant differences (P ≤0.05), between healthy controls and those athletes with RBT. Men with RBT showed higher levels of glutamine/glutamate (31%), choline (65%), fucosylated molecules (60%) and phenylalanine (46%). The results were evaluated and the sample size of five found to achieve a significance level P = 0.05 and a power of 90%. Differences in N-acetyl aspartate and myo-inositol between RBT and controls were small and were not statistically significance. Conclusions: A study of a small cohort of professional athletes, with a history of RBT and symptoms of chronic traumatic encephalopathy when compared with healthy controls using 2D L-COSY, showed elevations in brain glutamate/glutamine and choline as recorded previously for early traumatic brain injury. For the first time increases in phenylalanine and fucose are recorded in the brains of athletes with RBT. Larger studies utilizing the L-COSY method may offer an in-life method of diagnosis and personalized approach for monitoring the acute effects of mild traumatic brain injury and the chronic effects of RBT.]]> Wed 11 Apr 2018 12:16:35 AEST ]]> 2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> A dynamic model of brain hemodynamics in near-infrared spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37633 Thu 04 Mar 2021 11:02:51 AEDT ]]> Diffusion-weighted imaging of the breast: principles and clinical applications https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13275 Sat 24 Mar 2018 08:15:16 AEDT ]]> Diffusion-weighted imaging of the breast: comparison of B-values 1000 s/mm(2) and 1500 s/mm(2) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18367 Sat 24 Mar 2018 07:52:38 AEDT ]]> Transcranial direct current stimulation of prefrontal cortex: an auditory event-related potential and proton magnetic resonance spectroscopy study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20124 Sat 24 Mar 2018 07:51:45 AEDT ]]> Six fucose-alpha(1-2) sugars and alpha-fucose assigned in the human brain using in vivo two-dimensional MRS https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27115 Sat 24 Mar 2018 07:41:35 AEDT ]]> Utilisation of MR spectroscopy and diffusion weighted imaging in predicting and monitoring of breast cancer response to chemotherapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25640 Sat 24 Mar 2018 07:28:09 AEDT ]]> Glutamate and glutamine: a review of in vivo MRS in the human brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27598 Sat 24 Mar 2018 07:25:17 AEDT ]]> Lipid and metabolite deregulation in the breast tissue of women carrying BRCA1 and BRCA2 genetic mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27597 Sat 24 Mar 2018 07:25:17 AEDT ]]> L-COSY of breast cancer at 3T https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27596 Sat 24 Mar 2018 07:25:16 AEDT ]]> Automatic prediction of the conversion of clinically isolated syndrome to multiple sclerosis using deep learning https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37094 Mon 17 Aug 2020 12:34:46 AEST ]]> Fast magnetic resonance spectroscopic imaging techniques in human brain-applications in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30630 1H-MRS) and localization techniques principles, different fast MRSI techniques will be discussed from their initial development to the recent innovations with particular emphasis on their capacity to record neurochemical changes in the brain in a variety of pathologies. The clinical applications of whole brain fast spectroscopic techniques, can assist in the assessment of neurochemical changes in the human brain and help in understanding the roles they play in disease. To give a good example of the utilities of these techniques in clinical context, MRSI application in multiple sclerosis was chosen. The available up to date and relevant literature is discussed and an outline of future research is presented.]]> Mon 11 Mar 2019 12:08:59 AEDT ]]> Diurnal stability and long-term repeatability of neurometabolites using single voxel 1H magnetic resonance spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36797 Mon 06 Jul 2020 16:25:41 AEST ]]>