https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Cortex and amygdala morphology in psychopathy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12248 11). The cortex displayed up to 20% reduction in the orbitofrontal and midline structures (corrected p<0.001 bilaterally). Up to 30% tissue reduction in the basolateral nucleus, and 10–30% enlargement effects in the central and lateral nuclei indicated abnormal structure of the amygdala (corrected p=0.05 on the right; and symmetrical pattern on the left). Psychopathy features specific morphology of the main cerebral structures involved in cognitive and emotional processing, consistent with clinical and functional data, and with a hypothesis of an alternative evolutionary brain development.]]> Sat 24 Mar 2018 08:08:09 AEDT ]]> APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17935 0.29). Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both ε4-carriers and non-carriers compared with controls (e4 carriers: p < 0.0002; ε4 non-carriers: p < 0.01, permutation test). The left hippocampal volume was significantly smaller in ε4-carriers than non-carriers (p = 0.044, Mann–Whitney test), the effect of APOE4 mapping to the subicular/CA1 region (p = 0.041, permutation test). Differences were not statistically significant in the right hippocampus (p > 0.20, permutation test). These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology. APOE4 may affect the structural expression of Alzheimer's disease.]]> Sat 24 Mar 2018 07:56:34 AEDT ]]>