https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13674 Wed 24 Jun 2020 12:51:30 AEST ]]> PasMoQAP: a parallel asynchronous memetic algorithm for solving the Multi-Objective Quadratic Assignment Problem https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30426 Wed 23 Jan 2019 11:51:21 AEDT ]]> Genetic biomarkers for brain hemisphere differentiation in Parkinson's Disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9283 Wed 11 Apr 2018 18:36:27 AEST ]]> A new Memetic Algorithm for ordering datasets: applications in microarray analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3002 Wed 11 Apr 2018 17:22:49 AEST ]]> Strategies for enhancing communication between students, academics and researchers participating in large-scale undergraduate research projects https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20372 Wed 11 Apr 2018 16:58:08 AEST ]]> A new combinatorial optimization approach for integrated feature selection using different datasets: a prostate cancer transcriptomic study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24445 Wed 11 Apr 2018 16:51:11 AEST ]]> Mining disjunctive minimal generators with TitanicOR https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11086 Wed 11 Apr 2018 16:49:56 AEST ]]> An integrated QAP-based approach to visualize patterns of gene expression similarity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9259 Wed 11 Apr 2018 16:43:02 AEST ]]> Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13672 Wed 11 Apr 2018 16:23:10 AEST ]]> GPU-FS-kNN: a software tool for fast and scalable kNN computation using GPUs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15138 Wed 11 Apr 2018 16:14:13 AEST ]]> Alzheimer's disease patient groups derived from a multivariate analysis of cognitive test outcomes in the coalition against major diseases dataset https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25160 Wed 11 Apr 2018 16:09:03 AEST ]]> Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13671 Wed 11 Apr 2018 16:06:02 AEST ]]> A kernelisation approach for multiple d-hitting set and its application in optimal multi-drug therapeutic combinations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9494 Wed 11 Apr 2018 15:31:19 AEST ]]> Differences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's Disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13480 Wed 11 Apr 2018 15:24:54 AEST ]]> Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13673 Wed 11 Apr 2018 15:24:43 AEST ]]> Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24220 A and −174 G>C) correlate with MS susceptibility, but with varying results. In the present study, we analyzed these polymorphisms, together with an additional polymorphism (−572 G>C) in 279 healthy controls and 509 patients with MS. We found no significant differences between MS patients and healthy controls for the different −597 or −174 IL6 promoter alleles or genotypes. There was a slight reduction in the percentage of individuals with MS who carried a C allele at position −572, although this was not significant after correction for multiple comparisons. Interestingly, however, the −572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression.]]> Wed 11 Apr 2018 15:18:27 AEST ]]> Evolving robust gene regulatory networks https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27322 Wed 11 Apr 2018 14:52:52 AEST ]]> Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4456 Wed 11 Apr 2018 14:49:36 AEST ]]> Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease meuroimaging initiative (ADNI) plasma proteome dataset https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15120 Wed 11 Apr 2018 14:37:46 AEST ]]> Hierarchical clustering using the arithmetic-harmonic cut: complexity and experiments https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9497 Wed 11 Apr 2018 14:36:12 AEST ]]> Selection of discriminative genes in microarray experiments using mathematical programming https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9257 Wed 11 Apr 2018 14:26:22 AEST ]]> A parallel memetic algorithm applied to the total tardiness machine scheduling problem https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9262 Wed 11 Apr 2018 14:21:31 AEST ]]> An information theoretic clustering approach for unveiling authorship affinities in Shakespearean era plays and poems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16800 Wed 11 Apr 2018 14:17:27 AEST ]]> A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9503 Wed 11 Apr 2018 13:47:54 AEST ]]> Common and low frequency variants in MERTK are independently associated with multiple sclerosis susceptibility with discordant association dependent upon HLA-DRB1*15:01 status https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30273 MERTK has been established as an MS susceptibility gene and is part of a family of receptor tyrosine kinases known to be involved in the pathogenesis of demyelinating disease. In this study we have refined the association of MERTK with MS risk to independent signals from both common and low frequency variants. One of the associated variants was also found to be linked with increased expression of MERTK in monocytes and higher expression of MERTK was associated with either increased or decreased risk of developing MS, dependent upon HLA-DRB1*15:01 status. This discordant association potentially extended beyond MS susceptibility to alterations in disease course in established MS. This study provides clear evidence that distinct polymorphisms within MERTK are associated with MS susceptibility, one of which has the potential to alter MERTK transcription, which in turn can alter both susceptibility and disease course in MS patients.]]> Wed 11 Apr 2018 13:23:58 AEST ]]> Iteratively refining breast cancer intrinsic subtypes in the METABRIC dataset https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23687 Wed 11 Apr 2018 13:07:25 AEST ]]> Basal-like breast cancer: molecular profiles, clinical features and survival outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30824 Wed 11 Apr 2018 12:30:47 AEST ]]> Clustering consumers based on trust, confidence and giving behaviour: data-driven model building for charitable involvement in the Australian not-for-profit sector https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28310 Wed 11 Apr 2018 12:29:47 AEST ]]> Identification of differentially expressed genes through integrated study of alzheimer's disease affected brain regions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30004 Wed 11 Apr 2018 12:27:04 AEST ]]> Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13696 Wed 11 Apr 2018 12:04:40 AEST ]]> Cancer biomarker discovery: the entropic hallmark https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9568 Wed 11 Apr 2018 11:52:59 AEST ]]> Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7087 Wed 11 Apr 2018 11:42:37 AEST ]]> Integer programming models and algorithms for molecular classification of cancer from microarray data https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9263 Wed 11 Apr 2018 11:42:14 AEST ]]> QAPgrid: a two level QAP-based approach for large-scale data analysis and visualization https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15693 Wed 11 Apr 2018 11:41:55 AEST ]]> Heterogeneous ensemble combination search using genetic algorithm for class imbalanced data classification https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24365 Wed 11 Apr 2018 11:41:14 AEST ]]> Genome-wide analysis of long noncoding RNA stability https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21737 16 h). Analysis of lncRNA features revealed that intergenic and cis-antisense RNAs are more stable than those derived from introns, as are spliced lncRNAs compared to unspliced (single exon) transcripts. Subcellular localization of lncRNAs indicated widespread trafficking to different cellular locations, with nuclear-localized lncRNAs more likely to be unstable. Surprisingly, one of the least stable lncRNAs is the well-characterized paraspeckle RNA Neat1, suggesting Neat1 instability contributes to the dynamic nature of this subnuclear domain. We have created an online interactive resource (http://stability.matticklab.com) that allows easy navigation of lncRNA and mRNA stability profiles and provides a comprehensive annotation of ∼7200 mouse lncRNAs.]]> Wed 11 Apr 2018 11:06:11 AEST ]]> A data-driven approach to reverse engineering customer engagement models: towards functional constructs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16801 Wed 11 Apr 2018 09:24:30 AEST ]]> Evaluation of different normalization and analysis procedures for Illumina gene expression microarray data involving small changes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28613 Wed 11 Apr 2018 09:21:51 AEST ]]> Optimising weights for heterogeneous ensemble of classifiers with differential evolution https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25313 Wed 11 Apr 2018 09:18:04 AEST ]]> mQAPViz: A divide-and-conquer multi-objective optimization algorithm to compute large data visualizations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34958 Wed 04 Sep 2019 12:16:33 AEST ]]> Computer-aided breast cancer diagnosis with optimal feature sets: reduction rules and optimization techniques https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34298 Tue 26 Feb 2019 14:15:13 AEDT ]]> A memetic algorithm for community detection by maximising the connected cohesion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32234 Tue 15 May 2018 14:22:14 AEST ]]> Deep neural networks understand investors better https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35934 Thu 25 Jun 2020 12:19:41 AEST ]]> An adaptive memetic algorithm for feature selection using proxity graphs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36788 Thu 16 Jul 2020 16:04:16 AEST ]]> Language individuation and marker words: Shakespeare and his Maxwell's demon https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14966 Thu 12 Apr 2018 13:35:44 AEST ]]> An automatic graph layout procedure to visualize correlated data https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2864 Sat 24 Mar 2018 11:11:31 AEDT ]]> Memetic algorithms in bioinformatics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25267 Sat 24 Mar 2018 11:02:01 AEDT ]]> Common variants at 6p21.1 are associated with large artery atherosclerotic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13951 Sat 24 Mar 2018 10:41:26 AEDT ]]> A new greedy heuristic for 3DHP protein struture prediction with side chain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31540 Sat 24 Mar 2018 08:44:23 AEDT ]]> Novel biomarkers for prostate cancer revealed by (α,β)-k-feature sets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8461 Sat 24 Mar 2018 08:42:08 AEDT ]]> Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7518 Sat 24 Mar 2018 08:38:28 AEDT ]]> Shakespeare and other English Renaissance authors as characterized by Information Theory complexity quantifiers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7067 Sat 24 Mar 2018 08:38:03 AEDT ]]> Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8027 Sat 24 Mar 2018 08:36:47 AEDT ]]> Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity (II): a combinatorial optimization approach for electrode selection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7694 Sat 24 Mar 2018 08:33:34 AEDT ]]> Hierarchical clustering, languages and cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2952 Sat 24 Mar 2018 08:31:00 AEDT ]]> Evolutionary algorithms for scheduling a flowshop manufacturing cell with sequence dependent family setups https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1618 Sat 24 Mar 2018 08:30:34 AEDT ]]> Genes related with Alzheimer's disease: A comparison of evolutionary search, statistical and integer programming approaches https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2992 Sat 24 Mar 2018 08:30:21 AEDT ]]> Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12845 T at 3p24.1 (odds ratio [OR], 1.17; p = 1.6 × 10−8) near EOMES, rs2150702G in the second intron of MLANA on chromosome 9p24.1 (OR, 1.16; p = 3.3 × 10−8), and rs6718520A in an intergenic region on chromosome 2p21, with THADA as the nearest flanking gene (OR, 1.17; p = 3.4 × 10−8). The 3 new loci do not have a strong cis effect on RNA expression in PBMCs. Ten other susceptibility loci had a suggestive p < 1 × 10−6, some of these loci have evidence of association in other inflammatory diseases (ie, IL12B, TAGAP, PLEK, and ZMIZ1). Interpretation: We have performed a meta-analysis of GWAS in MS that more than doubles the size of previous gene discovery efforts and highlights 3 novel MS susceptibility loci. These and additional loci with suggestive evidence of association are excellent candidates for further investigations to refine and validate their role in the genetic architecture of MS.]]> Sat 24 Mar 2018 08:17:22 AEDT ]]> Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12709 Sat 24 Mar 2018 08:16:20 AEDT ]]> Engagement in motion: exploring short term dynamics in page-level social media metrics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17467 Sat 24 Mar 2018 08:04:12 AEDT ]]> Quantifying the regeneration of bone tissue in biomedical images via Legendre moments https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17820 Sat 24 Mar 2018 08:03:32 AEDT ]]> Gauging heterogeneity in online consumer behaviour data: a proximity graph approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18832 Sat 24 Mar 2018 08:03:17 AEDT ]]> Computing large-scale distance matrices on GPU https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16197 Sat 24 Mar 2018 08:03:05 AEDT ]]> kNN-MST-Agglomerative: a fast and scalable graph-based data clustering approach on GPU https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16196 Sat 24 Mar 2018 08:03:04 AEDT ]]> Identifying communities of trust and confidence in the charity and not-for-profit sector: a memetic algorithm approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18758 Sat 24 Mar 2018 08:02:46 AEDT ]]> Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18970 Sat 24 Mar 2018 07:58:53 AEDT ]]> Entropy-based high performance computation of Boolean SNP-SNP interactions using GPUs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20383 Sat 24 Mar 2018 07:58:08 AEDT ]]> Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20882 -/- mice, a model of hemochromatosis, relative to age- and gender-matched wildtype controls. Classification by functional pathway analysis revealed transcript changes for various genes important in AD. There were decreases of up to 9-fold in transcripts for amyloid-β protein precursor, tau, apolipoprotein E, presenilin 1, and various other γ-secretase components, as well as Notch signaling pathway molecules. This included decreased transcripts for 'hairy and enhancer of split' Hes1 and Hes5, downstream targets of Notch canonical signaling. The reductions in Hes1 and Hes5 transcripts provide evidence that the changes in levels of transcripts for γ-secretase components and Notch signaling genes have functional consequences. The effects appeared relatively specific for AD in that few genes pertaining to other important neurodegenerative diseases, notably Parkinson's disease and Huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. The observed effects on AD-related gene transcripts do not appear to be consistent with increased AD risk in HFE hemochromatosis and might, if anything, be predicted to protect against AD to some extent. As Hfe-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading.]]> Sat 24 Mar 2018 07:57:56 AEDT ]]> Beyond statistics: a new combinatorial approach to identifying biomarker panels for the early detection and diagnosis of Alzheimer's Disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17878 Sat 24 Mar 2018 07:56:13 AEDT ]]> A GPU-based method for computing eigenvector centrality of gene-expression networks https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16267 Sat 24 Mar 2018 07:54:14 AEDT ]]> Clustering nodes in large-scale biological networks using external memory algorithms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16274 Sat 24 Mar 2018 07:54:14 AEDT ]]> Disclosed: an efficient depth-first, top-down algorithm for mining disjunctive closed itemsets in high-dimensional data https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21139 Disclosed, mines disjunctive closed itemsets by exploring the search space in a depth-first, top-down manner. We evaluated the performance of our algorithm to execute such a task using real microarray gene expression data sets publicly available on the Internet. Our experiments revealed under what situations, the characteristics of a data set, our method obtain a good, bad or average performance. We also compared the performance of our method with the state of the art algorithms for finding disjunctive closed patterns and disjunctive minimal generators. We observed that our approach is two orders of magnitude more efficient, both in terms of time and memory.]]> Sat 24 Mar 2018 07:54:05 AEDT ]]> 'Neuroinflammation' differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21125 Sat 24 Mar 2018 07:53:55 AEDT ]]> Evolving L-systems as an intelligent design approach to find classes of difficult-to-solve traveling salesman problem instances https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16299 Sat 24 Mar 2018 07:53:23 AEDT ]]> kNN-Borůvka-GPU: a fast and scalable MST construction from <i>k</i>NN graphs on GPU https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21225 k-nearest neighbor (kNN) structure can provide an efficient solution to this problem. Only a few attempts were found in the literature that focus on solving the problem using the kNNs. This paper briefs the state-of-the-art strategies for the MST problem and a fast and scalable solution combining the classical Borůvka’s MST algorithm and the kNN graph structure. The proposed algorithm is implemented for CUDA enabled GPUs (kNN-Borůvka-GPU), but the basic approach is simple and adaptable to other available architectures. Speed-ups of 30-40 times compared with CPU implementation was observed for several large-scale synthetic and real world data sets.]]> Sat 24 Mar 2018 07:53:01 AEDT ]]> Brain transcriptome perturbations in the Hfe<sup>-/-</sup> mouse model of genetic iron loading https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21833 HFE gene. There is evidence from both human and animal studies that HFE gene variants may affect brain function and modify risks of brain disease. To investigate how disruption of HFE influences brain transcript levels, we used microarray and real-time reverse transcription polymerase chain reaction to assess the brain transcriptome in Hfe−/− mice relative to wildtype AKR controls (age 10 weeks, n ≥ 4/group). The Hfe−/− mouse brain showed numerous significant changes in transcript levels (p < 0.05) although few of these related to proteins directly involved in iron homeostasis. There were robust changes of at least 2-fold in levels of transcripts for prominent genes relating to transcriptional regulation (FBJ osteosarcoma oncogene Fos, early growth response genes), neurotransmission (glutamate NMDA receptor Grin1, GABA receptor Gabbr1) and synaptic plasticity and memory (calcium/calmodulin-dependent protein kinase IIα Camk2a). As previously reported for dietary iron-supplemented mice, there were altered levels of transcripts for genes linked to neuronal ceroid lipofuscinosis, a disease characterized by excessive lipofuscin deposition. Labile iron is known to enhance lipofuscin generation which may accelerate brain aging. The findings provide evidence that iron loading disorders can considerably perturb levels of transcripts for genes essential for normal brain function and may help explain some of the neurologic signs and symptoms reported in hemochromatosis patients.]]> Sat 24 Mar 2018 07:52:17 AEDT ]]> A new method for mining disjunctive emerging patterns in high-dimensional datasets using hypergraphs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18492 Sat 24 Mar 2018 07:51:23 AEDT ]]> Efficient data partitioning for the GPU computation of moment functions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18528 Sat 24 Mar 2018 07:50:20 AEDT ]]> Microarrays: identifying molecular portraits in prostrate tumors with different Gleason patterns https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6615 Sat 24 Mar 2018 07:46:21 AEDT ]]> Combinatorial optimization models for finding genetic signatures from gene expression datasets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6628 Sat 24 Mar 2018 07:46:19 AEDT ]]> Genetic signatures for a rodent model of Parkinson's disease using combinatorial optimization methods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6631 Sat 24 Mar 2018 07:46:19 AEDT ]]> An effective mutation-based measure for evaluating the suitability of parental sequences to undergo DNA shuffling experiments https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6195 Sat 24 Mar 2018 07:44:39 AEDT ]]> Relative neighborhood graphs uncover the dynamics of social media engagement https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25942 Sat 24 Mar 2018 07:41:27 AEDT ]]> Legendre moments as high performance bone biomarkers: computational methods and GPU acceleration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25959 Sat 24 Mar 2018 07:36:58 AEDT ]]> Memetic algorithms: a contemporary introduction https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29215 Sat 24 Mar 2018 07:36:46 AEDT ]]> Separating sets of strings by finding matching patterns is almost always hard https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29327 Sat 24 Mar 2018 07:34:24 AEDT ]]> GPU acceleration of an entroy-based model to quantify epistatic interactions between SNPs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26041 Sat 24 Mar 2018 07:26:27 AEDT ]]> Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25518 Sat 24 Mar 2018 07:26:01 AEDT ]]> Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25354 Sat 24 Mar 2018 07:24:42 AEDT ]]> Memetic algorithms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3893 Sat 24 Mar 2018 07:22:42 AEDT ]]> Enhancing the performance of memetic algorithms by using a matching-based recombination algorithm https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3851 Sat 24 Mar 2018 07:19:57 AEDT ]]> FSMEC: a feature selection method based on the minimum spanning tree and evolutionary computation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22915 (alpha,beta)-k-Feature Set, and a ranking-based feature selection method, based on the use of CM1-scores. We employ two publicly available real-world datasets (one with training and test variants). The classification accuracies have been evaluated using a total of 49 methods from an open source data mining and machine learning package WEKA.]]> Sat 24 Mar 2018 07:16:28 AEDT ]]> On ranking nodes using kNN graphs, shortest-paths and GPUs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22916 kNN graphs from DNA microarray data sets. The relationship among the genes in the kNN graph is determined by the similarity of their expression levels. The proposed method has been applied to a well known breast cancer microarray study and we highlighted the correlation of the highly ranked genes to the time to relapse of the disease. The method is readily applicable to other datasets, where the data points can be recognised in a multidimensional space. It can be applied to other networks (e.g., social networks, the Internet, etc.) with minimal modications.]]> Sat 24 Mar 2018 07:16:28 AEDT ]]> A memetic algorithm for the quadratic assignment problem with parallel local search https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23003 Sat 24 Mar 2018 07:15:42 AEDT ]]> Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25211 Sat 24 Mar 2018 07:14:02 AEDT ]]> MA-Net: a reliable memetic algorithm for community detection by modularity optimization https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23060 Sat 24 Mar 2018 07:12:28 AEDT ]]> A fast meta-heuristic approach for the (α, ß) - k-feature set problem https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24348 Sat 24 Mar 2018 07:10:17 AEDT ]]> Extensive transcriptomic and genomic analysis provides new insights about luminal breast cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25008 Mon 11 Mar 2019 12:12:36 AEDT ]]> A novel clustering methodology based on modularity optimisation for detecting authorship affinities in Shakespearean era plays https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29463 th and 17th centuries), to analyze and detect clusters of similar plays. Experimental results and comparison with state-of-the-art clustering methods demonstrate the remarkable performance of our new method for identifying high quality clusters which reflect the commonalities in the literary style of the plays.]]> Fri 24 Jul 2020 15:16:02 AEST ]]> Memetic algorithms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35259 Fri 05 Jul 2019 12:34:18 AEST ]]>