/manager/Index ${session.getAttribute("locale")} 5 Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse /manager/Repository/uon:14941 Wed 11 Apr 2018 17:19:33 AEST ]]> Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort /manager/Repository/uon:29133 Wed 11 Apr 2018 10:09:29 AEST ]]> Global survey of protein expression during gonadal sex determination in mice /manager/Repository/uon:7528 Sat 24 Mar 2018 08:38:31 AEDT ]]> Mouse germ cell development: from specification to sex determination /manager/Repository/uon:9702 Sat 24 Mar 2018 08:34:38 AEDT ]]> CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary /manager/Repository/uon:987 Sat 24 Mar 2018 08:29:49 AEDT ]]> Seeds of concern /manager/Repository/uon:2302 Sat 24 Mar 2018 08:26:58 AEDT ]]> A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice /manager/Repository/uon:11166 Sat 24 Mar 2018 08:08:30 AEDT ]]> Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression /manager/Repository/uon:20640 Sat 24 Mar 2018 07:55:44 AEDT ]]> RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus /manager/Repository/uon:27749 Drosophila and also shown to be vital to sperm development and reproductive potential in the mouse. We focus in depth on the role and function of the vertebrate Musashi ortholog Musashi-1 (MSI1). Through detailed expression studies and utilizing our novel transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation. We have also provided evidence to suggest that nuclear import protein, IPO5, facilitates the nuclear translocation of MSI1 to the transcriptionally silenced XY chromatin domain in meiotic pachytene spermatocytes, resulting in the release of MSI1 RNA-binding targets. This firmly establishes MSI1 as a master regulator of posttranscriptional control during early spermatogenesis and highlights the significance of the subcellular localization of RNA binding proteins in relation to their function.]]> Sat 24 Mar 2018 07:27:45 AEDT ]]> RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis /manager/Repository/uon:36766 Fri 03 Jul 2020 14:13:41 AEST ]]>