/manager/Index ${session.getAttribute("locale")} 5 The precursor for nerve growth factor (ProNGF) in thyroid cancer lymph node metastases: correlation with primary tumour and pathological variables /manager/Repository/uon:36624 Thu 24 Mar 2022 11:29:41 AEDT ]]> Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion /manager/Repository/uon:36968 2 [IQR 7–21]) compared to benign thyroid (6 nerves/cm2 [IQR: 3–10]) (p = 0.001). In contrast, no increase in nerve density was observed in FTC. In multivariate analysis, nerve density correlated positively with extrathyroidal invasion (p < 0.001), and inversely with tumour size (p < 0.001). The majority of nerves were adrenergic, although cholinergic and peptidergic innervation was detected. Perineural invasion was present in 35% of PTC, and was independently associated with extrathyroidal invasion (p = 0.008). This is the first report of infiltration of nerves into the tumour microenvironment of thyroid cancer and its association with tumour aggressiveness. The role of nerves in thyroid cancer pathogenesis should be further investigated.]]> Fri 22 Jul 2022 11:32:29 AEST ]]>