/manager/Index ${session.getAttribute("locale")} 5 A systematic review of associations of physical activity and sedentary time with asthma outcomes /manager/Repository/uon:35593 Thu 28 Oct 2021 13:03:46 AEDT ]]> Physical activity associates with disease characteristics of severe asthma, bronchiectasis and COPD /manager/Repository/uon:36371 Thu 17 Feb 2022 09:31:36 AEDT ]]> Physical activity and exercise capacity in severe asthma: key clinical associations /manager/Repository/uon:33710 Thu 17 Feb 2022 09:25:26 AEDT ]]> Extrapulmonary associations of health status in severe asthma and bronchiectasis: comorbidities and functional outcomes /manager/Repository/uon:35398 0.05), and similar pulmonary and extrapulmonary characteristics. The associations between extrapulmonary variables and HRQoL did not differ according to diagnosis (all interactions p > 0.05). Greater anxiety and depressive symptoms, fewer steps/day and greater systemic inflammation were statistically associated with poorer HRQoL in both diseases (p < 0.05). Lower isometric leg strength in severe asthma, and greater Charlson Comorbidity Index in bronchiectasis were also associated with poorer HRQoL (p < 0.05). In the multivariable regression model performed in the combined disease groups, anxiety and depression, steps/day, systemic inflammation and isometric leg strength remained independently associated with HRQoL. Associations between extrapulmonary characteristics and SGRQ domains were stronger for the activity and impact domains, than symptoms. Conclusion: In severe asthma and bronchiectasis, extrapulmonary features including physical activity and leg strength have a significant impact on HRQoL, especially within the activity and impact domains. These features should be considered as part of the assessment of these conditions, and they may represent additional treatment targets to improve HRQoL.]]> Thu 09 Dec 2021 11:03:51 AEDT ]]> Targeting treatable traits in severe asthma: a randomised controlled trial /manager/Repository/uon:44178 Mon 10 Oct 2022 10:20:29 AEDT ]]> Identification of asthma phenotypes based on extrapulmonary treatable traits /manager/Repository/uon:46329 Fri 18 Nov 2022 09:59:09 AEDT ]]>