https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Kif4 is essential for mouse oocyte meiosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30985 Wed 11 Apr 2018 14:34:15 AEST ]]> Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29296 DEAD (Asp-Glu-Ala-Asp) box protein 4 (Ddx4) gene promoter. Histopathological and functional analysis of ovaries from these mutant mice (Ctnnb1ex3cko) showed no defects in ovarian functions, oocytes, ovulation and early embryonic development. However, breeding of the Ctnnb1ex3cko female mice with males of known fertility never resulted in birth of mutant pups. Examination of uteri from time pregnant mutant females revealed defects in ectoderm differentiation leading to abnormal foetal development and premature death. Collectively, our work has established the role of active WNT/βcatenin signalling in oocyte biology and foetal development, and provides novel insights into the possible mechanisms of complications in human pregnancy such as repeated spontaneous abortion, sudden intrauterine unexpected foetal death syndrome and stillbirth.]]> Wed 11 Apr 2018 13:03:48 AEST ]]> The small non-coding RNA profile of mouse oocytes is modified during aging https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35834 Kifc1 and Kifc5b, in aged oocytes; family members selectively targeted for expression regulation by endo-siRNAs of elevated abundance. The implications of reduced Kifc1 and Kifc5b expression were explored using complementary siRNA-mediated knockdown and pharmacological inhibition strategies, both of which led to increased rates of aneuploidy in otherwise healthy young oocytes. Collectively, our data raise the prospect that altered sRNA abundance, specifically endo-siRNA abundance, could influence the quality of the aged oocyte.]]> Tue 10 Dec 2019 16:34:23 AEDT ]]> Through the smoke: Use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18819 Sat 24 Mar 2018 07:51:08 AEDT ]]> Maternal smoke exposure impairs the long-term fertility of female offspring in a murine model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29938 Sat 24 Mar 2018 07:30:56 AEDT ]]> Motoring through: the role of kinesin superfamily proteins in female meiosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30367 Sat 24 Mar 2018 07:26:47 AEDT ]]> Maternal smoke exposure impairs the long-term fertility of a female offspring in a murine model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21996 Sat 24 Mar 2018 07:14:33 AEDT ]]>