/manager/Index ${session.getAttribute("locale")} 5 Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness /manager/Repository/uon:29641 Sat 24 Mar 2018 07:41:54 AEDT ]]> Evidence for genetic overlap between schizophrenia and age at first birth in women. /manager/Repository/uon:29862 2 = 1.1E-03, P = 4.1E-04), reflecting the published relationship between maternal age and SCZ risk in offspring by McGrath et al in 2014. Conclusions and Relevance: This study provides evidence for a significant overlap between genetic factors associated with risk of SCZ and genetic factors associated with AFB. It has been reported that SCZ risk associated with increased maternal age is explained by the age of the father and that de novo mutations that occur more frequently in the germline of older men are the underlying causal mechanism. This explanation may need to be revised if, as suggested herein and if replicated in future studies, there is also increased genetic risk of SCZ in older mothers.]]> Sat 24 Mar 2018 07:40:47 AEDT ]]>