https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41907 Wed 13 Mar 2024 09:35:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14492 c of 440 ms or 500 ms. Plotting the QT-HR pair for patients on drugs suspected or known to cause QT prolongation allows assessment of the QT interval based on normal population QT variability. This risk assessment then allows the safer commencement of drugs therapeutically or management of drug induced effects in overdose.]]> Wed 11 Apr 2018 10:07:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33891 four levels of wavelet packet decomposition (WPD) to obtain various coefficients. Using the fourth-level coefficients obtained for each lead ECG signal beat, new 2s. ECG signal beats are reconstructed. Later, the reconstructed signals are split into two-fold data sets, in which one set is used for acquiring common spatial pattern (CSP) filter and the other for obtaining features vector (vice versa). The obtained features are one by one fed into k-nearest neighbors (KNN) classifier for automated classification. The proposed system yielded maximum average classification results of 99.65% accuracy, 99.64% sensitivity and 99.7% specificity using 10 features. Our proposed algorithm is highly efficient and can be used by the clinicians as an aiding system in their CAD diagnosis, thus, assisting in faster treatment and avoiding the progression of CAD condition.]]> Tue 22 Jan 2019 14:22:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32767 Thu 24 Mar 2022 11:34:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8167 440 msec) was assessed by kappa coefficients. Results: QT interval intraobserver ICC was 0.86 and repeatability coefficient was 25.9 msec; interobserver ICC increased from 0.88 for single observations to 0.94 for the average of 3 measurements and repeatability coefficients decreased from 22.5 to 16.7 msec. For QTcB, intraobserver ICC was 0.67, and repeatability was 39.6 msec. Best interobserver reliability for QTcB was for the average of three measurements (ICC 0.83, reproducibility coefficient 25.8 msec), with further improvement for QTcH (ICC 0.92, reproducibility coefficient 16.69 msec). Maximum interobserver kappa for prolonged QTc was 0.77. Misclassification around specific cut points occurs because of the repeatability coefficients. Conclusions: Uncorrected QT measures are more reliable than QTcB and QTCFrid. An average of three independent measures provides the most reliable QT and QTc measurements, with QTcH better than QTcB.]]> Sat 24 Mar 2018 08:36:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14457 120 mg) identified from admissions to a toxicology unit between January 1987 and August 2013. Demographic information, details of ingestion, clinical effects, ECG parameters (HR, QT and QRS), and length of stay were extracted from a clinical database. Results: From 267 mirtazapine overdoses, there were 89 single-agent mirtazapine ingestions and 178 cases where mirtazapine was taken with at least one other drug. The median age of the 89 single-agent mirtazapine ingestions was 36 years [interquartile range (IQR): 26 – 49 years; Range: 15 – 81 years]; 45 were female (51%). The median ingested dose was 420 mg (IQR: 270 – 750 mg; Range: 150 – 1350 mg) and 41 patients (46%) had a Glasgow coma score (GCS) < 15, but the minimum GCS was 10. There were no seizures, serotonin toxicity or delirium. Tachycardia occurred in 29 patients (33%) and hypertension in 32 patients (36%). The median QRS was 80 ms (Range: 80 – 120 ms) and there were no cases with QT prolongation. There were no arrhythmias and no deaths. The median length of stay was 14 h (IQR: 8.8 – 18.2 h; Range:2.2 – 75 h). No single-agent mirtazapine patient was admitted to intensive care. The 178 patients taking co-ingestants had more severe toxicity depending on the co-ingested drug. Conclusion: Mirtazapine appears to be relatively benign in overdose, associated with tachycardia, mild hypertension and mild CNS depression not requiring intervention.]]> Sat 24 Mar 2018 08:19:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21162 Sat 24 Mar 2018 07:58:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36870 Mon 13 Jul 2020 16:25:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51593 Mon 11 Sep 2023 15:32:24 AEST ]]>