https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Regulation of cardiac calcium release channels during acute beta-adrenergic stimulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13385 Wed 11 Apr 2018 17:04:51 AEST ]]> Mechanisms of cardiac ryanodine receptor inhibition by anti arrhythmic drugs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14428 Wed 11 Apr 2018 13:17:59 AEST ]]> Mechanisms of SR calcium release in healthy and failing human hearts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27466 2+) into cardiac cells and between their intracellular organelles, and any disruption can lead to arrhythmia and sudden cardiac death. Electrical excitation of the surface membrane activates voltage-dependent L-type Ca2+ channels to open and allow Ca2+ to enter the cytoplasm. The subsequent increase in cytoplasmic Ca2+ concentration activates calcium release channels (RyR2) located at specialised Ca2+ release sites in the sarcoplasmic reticulum (SR), which serves as an intracellular Ca2+ store. Animal models have provided valuable insights into how intracellular Ca2+ transport mechanisms are altered in human heart failure. The aim of this review is to examine how Ca2+ release sites are remodelled in heart failure and how this affects intracellular Ca2+ transport with an emphasis on Ca2+ release mechanisms in the SR. Current knowledge on how heart failure alters the regulation of RyR2 by Ca2+ and Mg2+ and how these mechanisms control the activity of RyR2 in the confines of the Ca2+ release sites is reviewed.]]> Sat 24 Mar 2018 07:32:43 AEDT ]]>