https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Finding transcription factor binding site: Markov Chain Monte Carlo convergence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2897 Wed 24 Jul 2013 22:54:23 AEST ]]> Source monitoring for pictures: an exploration of factors which affect performance https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10835 Wed 11 Apr 2018 13:11:06 AEST ]]> Binding within the Bulgarian nominal phrase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:943 Wed 11 Apr 2018 13:09:22 AEST ]]> Ab initio and DFT cation affinity study of selected neurosteroids https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:474 Sat 24 Mar 2018 11:02:58 AEDT ]]> Combining structure-based drug design and pharmacophores https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:295 Sat 24 Mar 2018 07:43:42 AEDT ]]> The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:310 Sat 24 Mar 2018 07:42:41 AEDT ]]> Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28373 Escherichia coli sliding clamp occurs via a sequential mechanism that involves two subsites (I and II). Here, we report the development of small-molecule inhibitors that mimic this mechanism. The compounds contain tetrahydrocarbazole moieties as "anchors" to occupy subsite I. Functional groups appended at the tetrahydrocarbazole nitrogen bind to a channel gated by the side chain of M362 and lie at the edge of subsite II. One derivative induced the formation of a new binding pocket, termed subsite III, by rearrangement of a loop adjacent to subsite I. Discovery of the extended binding area will guide further inhibitor development.]]> Sat 24 Mar 2018 07:35:58 AEDT ]]>