https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Advanced magnetic resonance spectroscopic techniques for neurometabolic profiling of multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36699 Wed 24 Jun 2020 18:21:42 AEST ]]> The application of magnetic resonance spectroscopy to investigate the effect of a commercial energy drink https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27129 in-vivo measurement of brain biochemistry. The objective of this study was to explore the effects of a commercial energy drink (ED) on brain metabolites in adult males using MRS. Methods: Ten males (18 to 30 years), of mean body mass index 23.8±2.2 kg/m² [range 21.4-27.8 kg/m²] were recruited and randomized to either the intervention group (n=5) or control group (n=5). The intervention group were asked to consume two 250ml cans of Red Bull and the control group consumed no drink. One dimensional MRS on a 1.5T Achieva MRI scanner was obtained of bi-occipital gray matter. Subjects were placed in the scanner and a spectrum acquired every 5.75 minutes for 60 minutes. Linear mixed models were generated to determine the main effects due to differences between groups and times and the interaction. Results: There was a significant group by time effect for N-acetylaspartate (NAA) (P= .02, d= 0.7) and a statistical trend for macromolecule 20 (MM20) (P= .06 d= 0.1) with the control group having higher concentrations than that of the intervention. Mean differences from baseline to 45 minutes for NAA in the intervention group were -0.8 mM (-12%) compared with 0.15 mM (<1%) for control and for MM20 -0.12 mM (<1%) in the intervention group compared with 0.03 mM (<1%) for control. Conclusions: Consumption of two cans of ED was found to produce few changes in brain metabolites with moderate effect sizes. Changes detected in this study demonstrate the sensitivity of the MRS method to explore nutrition related variables with 1.5T clinical MRI unit. The study provides some insight into an understudied, topical area of research.]]> Wed 11 Apr 2018 12:09:41 AEST ]]> 2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> Glutamate and glutamine: a review of in vivo MRS in the human brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27598 Sat 24 Mar 2018 07:25:17 AEDT ]]> L-COSY of breast cancer at 3T https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27596 Sat 24 Mar 2018 07:25:16 AEDT ]]> Magnetic Resonance Spectroscopy (MRS) to document changes in neurochemistry https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34385 Mon 23 Sep 2019 12:19:25 AEST ]]>