https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Lipid and metabolite deregulation in BRCA1 and BRCA2 genetic mutations: response https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24236 Wed 16 Nov 2016 14:36:47 AEDT ]]> Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18959 Sat 24 Mar 2018 07:58:54 AEDT ]]> Whole-brain CT perfusion to quantify acute ischemic penumbra and core https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29863 n = 296) who underwent 320-detector CT perfusion within 6 hours of the onset of ischemic stroke were studied. First, the ischemic volume at CT perfusion was compared with the penumbra and core reference values at magnetic resonance (MR) imaging to derive CT perfusion penumbra and core thresholds. Second, the thresholds were tested in a different group of patients to predict the final infarction at diffusion-weighted imaging 24 hours after CT perfusion. Third, the change in ischemic volume delineated by the optimal penumbra and core threshold was determined as the brain coverage was gradually reduced from 160 mm to 20 mm. The Wilcoxon signed-rank test, concordance correlation coefficient (CCC), and analysis of variance were used for the first, second, and third steps, respectively. Results: CT perfusion at penumbra and core thresholds resulted in the least volumetric difference from MR imaging reference values with delay times greater than 3 seconds and delay-corrected cerebral blood flow of less than 30% (P = .34 and .33, respectively). When the thresholds were applied to the new group of patients, prediction of the final infarction was allowed with delay times greater than 3 seconds in patients with no recanalization of the occluded artery (CCC, 0.96 [95% confidence interval: 0.92, 0.98]) and with delay-corrected cerebral blood flow less than 30% in patients with complete recanalization (CCC, 0.91 [95% confidence interval: 0.83, 0.95]). However, the ischemic volume with a delay time greater than 3 seconds was underestimated when the brain coverage was reduced to 80 mm (P = .04) and the core volume measured as cerebral blood flow less than 30% was underestimated when brain coverage was 40 mm or less (P < .0001). Conclusion: Correct threshold setting and whole-brain coverage CT perfusion allowed differentiation of the penumbra from the ischemic core in patients with acute ischemic stroke.]]> Sat 24 Mar 2018 07:40:47 AEDT ]]> Lipid and metabolite deregulation in the breast tissue of women carrying BRCA1 and BRCA2 genetic mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27597 Sat 24 Mar 2018 07:25:17 AEDT ]]> Response to lipid and metabolite deregulation in BRCA1 and BRCA2 genetic mutations (letter) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25019 Sat 24 Mar 2018 07:10:41 AEDT ]]>