https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11120 Wed 11 Apr 2018 13:59:42 AEST ]]> Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14350 +). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S+-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.]]> Wed 11 Apr 2018 11:48:59 AEST ]]> Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14894 Wed 11 Apr 2018 10:51:50 AEST ]]> Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15458 Wed 11 Apr 2018 10:32:17 AEST ]]> Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15926 Wed 11 Apr 2018 10:07:44 AEST ]]> Drug-induced changes to lateral hypothalamic circuits and downstream projection targets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21950 Wed 11 Apr 2018 09:46:58 AEST ]]> Chemogenetic activation of the lateral hypothalamus reverses early life stress-induced deficits in motivational drive https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32927 Tue 14 Aug 2018 14:59:36 AEST ]]>