https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The small non-coding RNA profile of mouse oocytes is modified during aging https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35834 Kifc1 and Kifc5b, in aged oocytes; family members selectively targeted for expression regulation by endo-siRNAs of elevated abundance. The implications of reduced Kifc1 and Kifc5b expression were explored using complementary siRNA-mediated knockdown and pharmacological inhibition strategies, both of which led to increased rates of aneuploidy in otherwise healthy young oocytes. Collectively, our data raise the prospect that altered sRNA abundance, specifically endo-siRNA abundance, could influence the quality of the aged oocyte.]]> Tue 10 Dec 2019 16:34:23 AEDT ]]> Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34948 Tue 03 Sep 2019 17:57:02 AEST ]]>