/manager/Index ${session.getAttribute("locale")} 5 Mechanisms of SR calcium release in healthy and failing human hearts /manager/Repository/uon:27466 2+) into cardiac cells and between their intracellular organelles, and any disruption can lead to arrhythmia and sudden cardiac death. Electrical excitation of the surface membrane activates voltage-dependent L-type Ca2+ channels to open and allow Ca2+ to enter the cytoplasm. The subsequent increase in cytoplasmic Ca2+ concentration activates calcium release channels (RyR2) located at specialised Ca2+ release sites in the sarcoplasmic reticulum (SR), which serves as an intracellular Ca2+ store. Animal models have provided valuable insights into how intracellular Ca2+ transport mechanisms are altered in human heart failure. The aim of this review is to examine how Ca2+ release sites are remodelled in heart failure and how this affects intracellular Ca2+ transport with an emphasis on Ca2+ release mechanisms in the SR. Current knowledge on how heart failure alters the regulation of RyR2 by Ca2+ and Mg2+ and how these mechanisms control the activity of RyR2 in the confines of the Ca2+ release sites is reviewed.]]> Sat 24 Mar 2018 07:32:43 AEDT ]]> Ryanodine receptor modification and regulation by intracellular Ca²⁺ and Mg²⁺ in healthy and failing human hearts /manager/Repository/uon:33274 Mon 24 Sep 2018 13:26:22 AEST ]]>