https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the primary therapy of early breast cancer 2015 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22889 Annals of Oncology online.]]> Wed 11 Apr 2018 11:24:51 AEST ]]> Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8225 Sat 24 Mar 2018 08:40:37 AEDT ]]> Which patients benefit most from adjuvant aromatase inhibitors?: results using a composite measure of prognostic risk in the BIG 1-98 randomized trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17752 Sat 24 Mar 2018 07:57:20 AEDT ]]> Symptoms of endocrine treatment and outcome in the BIG 1-98 study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21321 n = 4,798) and at the 12-month landmark (n = 4,682) were used for this report. Cohorts of patients with vasomotor symptoms, AMC symptoms, neither, or both were defined at both 3 and 12 months from randomization. Landmark analyses were performed for disease-free survival (DFS) and for breast cancer free interval (BCFI), using regression analysis to estimate hazard ratios (HR) and 95 % confidence intervals (CI). Median follow-up was 7.0 years. Reporting of AMC symptoms was associated with better outcome for both the 3- and 12-month landmark analyses [e.g., 12-month landmark, HR (95 % CI) for DFS = 0.65 (0.49-0.87), and for BCFI = 0.70 (0.49-0.99)]. By contrast, reporting of vasomotor symptoms was less clearly associated with DFS [12-month DFS HR (95 % CI) = 0.82 (0.70-0.96)] and BCFI (12-month DFS HR (95 % CI) = 0.97 (0.80-1.18). Interaction tests indicated no effect of treatment group on associations between symptoms and outcomes. While reporting of AMC symptoms was clearly associated with better DFS and BCFI, the association between vasomotor symptoms and outcome was less clear, especially with respect to breast cancer-related events.]]> Sat 24 Mar 2018 07:52:52 AEDT ]]>