/manager/Index ${session.getAttribute("locale")} 5 Genome-wide association study of retinopathy in individuals without diabetes /manager/Repository/uon:15067 Wed 11 Apr 2018 16:52:00 AEST ]]> Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis /manager/Repository/uon:15068 Wed 11 Apr 2018 13:50:10 AEST ]]> Associations between methylenetetrahydrofolate reductase polymorphisms, serum homocysteine levels, and incident cortical cataract /manager/Repository/uon:29933 15 µmol/L: OR = 2.24; 95% CI = 1.38-3.63) were independently associated with increased risk of cortical cataract. Path analysis showed that the genetic effect on cortical cataract was partially mediated via homocysteine levels. Combined CT/TT genotypes and elevated homocysteine levels were associated with a 3-fold risk of cortical cataract (OR = 3.74; 95% CI = 1.79-7.80). The synergy index of both exposures was 1.34 (95% CI = 0.44-4.01). Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels contributed separately and jointly to increased risk of cortical cataract. If these findings are confirmed, homocysteine levels may be a therapeutic target to reduce risk of cortical cataract in persons carrying genetic risk.]]> Sat 24 Mar 2018 07:31:02 AEDT ]]>