/manager/Index ${session.getAttribute("locale")} 5 Cerebellar grey-matter deficits, cannabis use and first-episode schizophrenia in adolescents and young adults /manager/Repository/uon:19046 Wed 20 May 2020 07:09:22 AEST ]]> Genetic markers of human evolution are enriched in schizophrenia /manager/Repository/uon:25928 −9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development. Conclusions: Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.]]> Wed 12 Aug 2020 09:42:59 AEST ]]> Genome-wide association study identifies five new schizophrenia loci /manager/Repository/uon:14264 −11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10−9), ANK3 (rs10994359, P = 2.5 × 10−8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10−9).]]> Wed 11 Apr 2018 18:45:05 AEST ]]> Visual perception and processing in children with 22q11.2 deletion syndrome: associations with social cognition measures of face identity and emotion recognition /manager/Repository/uon:30124 Wed 11 Apr 2018 17:22:19 AEST ]]> Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis /manager/Repository/uon:10485 Wed 11 Apr 2018 17:20:37 AEST ]]> Mismatch negativity (MMN) in freely-moving rats with several experimental controls /manager/Repository/uon:16819 Wed 11 Apr 2018 17:19:46 AEST ]]> Epidural auditory event-related potentials in the rat to frequency and duration deviants: evidence of mismatch negativity? /manager/Repository/uon:9724 Wed 11 Apr 2018 16:32:53 AEST ]]> Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia /manager/Repository/uon:23292 Wed 11 Apr 2018 15:09:07 AEST ]]> No reliable association between runs of homozygosity and schizophrenia in a well-powered replication study /manager/Repository/uon:27630 Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.]]> Wed 11 Apr 2018 14:15:34 AEST ]]> Subtypes in 22q11.2 deletion syndrome associated with behaviour and neurofacial morphology /manager/Repository/uon:23140 Wed 11 Apr 2018 13:22:01 AEST ]]> Paracingulate sulcus morphology is associated with hallucinations in the human brain /manager/Repository/uon:22665 Wed 11 Apr 2018 12:37:33 AEST ]]> Mismatch negativity: translating the potential /manager/Repository/uon:20577 Wed 11 Apr 2018 12:29:02 AEST ]]> Mismatch negativity in recent-onset and chronic schizophrenia: a current source density analysis /manager/Repository/uon:16820 Wed 11 Apr 2018 12:28:20 AEST ]]> Nicotinic antagonist effects on functional attention networks /manager/Repository/uon:7853 Wed 11 Apr 2018 12:08:09 AEST ]]> Ten-year audit of clients presenting to a specialised service for young people experiencing or at increased risk for psychosis /manager/Repository/uon:16754 Wed 11 Apr 2018 10:51:14 AEST ]]> Electrophysiological, cognitive and clinical profiles of at-risk mental state: the longitudinal Minds in Transition (MinT) study /manager/Repository/uon:30417 Wed 11 Apr 2018 10:16:02 AEST ]]> Pre-pulse inhibition and antisaccade performance indicate impaired attention modulation of cognitive inhibition in 22q11.2 deletion syndrome (22q11DS) /manager/Repository/uon:16792 Wed 11 Apr 2018 09:36:57 AEST ]]> Muscarinic antagonist effects on executive control of attention /manager/Repository/uon:7855 Wed 11 Apr 2018 09:36:20 AEST ]]> 10Kin1day: a bottom-up neuroimaging initiative /manager/Repository/uon:36591 Wed 10 Jun 2020 14:23:24 AEST ]]> Impact of rurality and substance use on young people at ultra-high risk for psychosis /manager/Repository/uon:36084 Wed 05 Feb 2020 14:23:07 AEDT ]]> Utility of risk-status for predicting psychosis and related outcomes: evaluation of a 10-year cohort of presenters to a specialised early psychosis community mental health service /manager/Repository/uon:33211 without (35.4%, the reference group) and with psychiatric admissions (8.3%); and incomplete assessments (12.5%). High comorbidity levels were reported by the cohort (psychosocial problems, 61.1%; depression, 54.1%; substance misuse, 40.7%). UHR clients experienced similar psychosis transition rates to the reference group (17.3% vs. 14.6%; 8.9% vs. 9.1% within 2-years) and comparable rates of subsequent non-psychosis outcomes. A 25.9% conversion rate from early psychosis to schizophrenia was detected. However, among transitioning individuals, UHR clients faired relatively better, particularly with respect to changes in comorbidity and mental health contacts. Interventions tailored to current problems, recovery and psychological strengthening may be more appropriate than those based on estimated psychosis risk, which currently lacks clinical utility.]]> Wed 04 Sep 2019 10:05:29 AEST ]]> Genetic correlation between amyotrophic lateral sclerosis and schizophrenia /manager/Repository/uon:34119 -4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.]]> Wed 04 Sep 2019 09:40:14 AEST ]]> Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects /manager/Repository/uon:34283 −15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10−6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10−11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10−5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.]]> Tue 03 Sep 2019 18:30:49 AEST ]]> Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) consortium /manager/Repository/uon:33388 Tue 03 Sep 2019 17:54:11 AEST ]]> A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework /manager/Repository/uon:33389 Tue 03 Sep 2019 17:54:01 AEST ]]> Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching /manager/Repository/uon:561 Thu 25 Jul 2013 09:10:39 AEST ]]> Dyssomnia in children diagnosed with attention deficit hyperactivity disorder: a critical review /manager/Repository/uon:12 Thu 25 Jul 2013 09:10:12 AEST ]]> Identification of gene loci that overlap between schizophrenia and educational attainment /manager/Repository/uon:34615 Thu 04 Apr 2019 09:04:20 AEDT ]]> Transcranial direct current stimulation /manager/Repository/uon:13749 Sat 24 Mar 2018 10:39:19 AEDT ]]> Consciousness and hallucinations in schizophrenia: secondary aspects of generalized neuropil pathology? (letter) /manager/Repository/uon:7292 Sat 24 Mar 2018 08:42:13 AEDT ]]> Visual scanning of faces in 22q11.2 deletion syndrome: attention to the mouth or the eyes? /manager/Repository/uon:9528 Sat 24 Mar 2018 08:35:32 AEDT ]]> Risk factors for transition to first episode psychosis among individuals with 'at-risk mental states' /manager/Repository/uon:1927 Sat 24 Mar 2018 08:33:12 AEDT ]]> Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia /manager/Repository/uon:1288 Sat 24 Mar 2018 08:32:45 AEDT ]]> Dorsolateral prefrontal cortex activation during automatic auditory duration-mismatch processing in humans: a positron emission tomography study /manager/Repository/uon:1314 Sat 24 Mar 2018 08:32:44 AEDT ]]> Disrupted sensory gating in pathological gambling /manager/Repository/uon:1670 Sat 24 Mar 2018 08:30:26 AEDT ]]> Functional brain maps of Tower of London performance: a positron emission tomography and functional magnetic resonance imaging study /manager/Repository/uon:1711 Sat 24 Mar 2018 08:27:39 AEDT ]]> Functional neuroanatomy of auditory mismatch processing: an event-related fMRI study of duration-deviant oddballs /manager/Repository/uon:1712 Sat 24 Mar 2018 08:27:39 AEDT ]]> Functional MRI of facial emotion recognition deficits in schizophrenia and their electrophysiological correlates /manager/Repository/uon:1771 Sat 24 Mar 2018 08:27:36 AEDT ]]> Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching /manager/Repository/uon:1772 Sat 24 Mar 2018 08:27:35 AEDT ]]> Visual scanpath abnormalities in 22q11.2 deletion syndrome: is this a face specific deficit? /manager/Repository/uon:12493 Sat 24 Mar 2018 08:17:11 AEDT ]]> Cerebellar grey matter deficits in first-episode schizophrenia mapped using cortical pattern matching /manager/Repository/uon:10763 Sat 24 Mar 2018 08:13:54 AEDT ]]> Australian schizophrenia research bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia /manager/Repository/uon:10415 Sat 24 Mar 2018 08:12:38 AEDT ]]> Young rural people at risk for schizophrenia: time for mental health services to translate research evidence into best practice of care /manager/Repository/uon:10463 Sat 24 Mar 2018 08:09:11 AEDT ]]> Autonomic hyper-vigilance in post-infective fatigue syndrome /manager/Repository/uon:10148 Sat 24 Mar 2018 08:07:28 AEDT ]]> Mismatch negativity (MMN) reduction in schizophrenia - impaired prediction-error generation, estimation or salience? /manager/Repository/uon:20443 Sat 24 Mar 2018 08:06:54 AEDT ]]> What's intact and what's not within the mismatch negativity system in schizophrenia /manager/Repository/uon:18307 Sat 24 Mar 2018 08:04:41 AEDT ]]> Repetition suppression of the rat auditory evoked potential at brief stimulus intervals /manager/Repository/uon:19902 Sat 24 Mar 2018 08:03:48 AEDT ]]> Divergent patterns of social cognition performance in autism and 22q11.2 deletion syndrome (22q11DS) /manager/Repository/uon:20081 Sat 24 Mar 2018 08:00:08 AEDT ]]> Temporal processing ability is related to ear-asymmetry for detecting time cues in sound: a mismatch negativity (MMN) study /manager/Repository/uon:17969 Sat 24 Mar 2018 07:56:23 AEDT ]]> Age effects on cerebral grey matter and their associations with psychopathology, cognition and treatment response in previously untreated schizophrenia patients /manager/Repository/uon:20972 Sat 24 Mar 2018 07:54:21 AEDT ]]> Biological insights from 108 schizophrenia-associated genetic loci /manager/Repository/uon:21465 DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> Transcranial direct current stimulation of prefrontal cortex: an auditory event-related potential and proton magnetic resonance spectroscopy study /manager/Repository/uon:20124 Sat 24 Mar 2018 07:51:45 AEDT ]]> Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication /manager/Repository/uon:20137 Sat 24 Mar 2018 07:51:34 AEDT ]]> Transcranial direct current stimulation of prefrontal cortex: an auditory event-related potential study in schizophrenia /manager/Repository/uon:18814 Sat 24 Mar 2018 07:51:01 AEDT ]]> Generalization of cognitive training in an Australian sample of schizophrenia patients /manager/Repository/uon:19993 Sat 24 Mar 2018 07:50:47 AEDT ]]> Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway /manager/Repository/uon:18570 Sat 24 Mar 2018 07:50:10 AEDT ]]> Deviant matters: duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia /manager/Repository/uon:5114 Sat 24 Mar 2018 07:48:57 AEDT ]]> Dual constraints on synapse formation and regression in schizophrenia: more evidence required (letter) /manager/Repository/uon:5437 Sat 24 Mar 2018 07:48:14 AEDT ]]> Functional MRI of facial emotion recognition deficits in schizophrenia and their electrophysiological correlates /manager/Repository/uon:394 Sat 24 Mar 2018 07:42:33 AEDT ]]> Functional magnetic resonance brain imaging of executive cognitive performance in young first-episode schizophrenia patients and age-matched long-term cannabis users /manager/Repository/uon:26883 Sat 24 Mar 2018 07:41:40 AEDT ]]> A randomised controlled trial of cognitive behaviour therapy versus non-directive reflective listening for young people at ultra high risk of developing psychosis: the detection and evaluation of psychological therapy (DEPTh) trial /manager/Repository/uon:29913 Sat 24 Mar 2018 07:40:55 AEDT ]]> Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response /manager/Repository/uon:26102 Sat 24 Mar 2018 07:39:52 AEDT ]]> Psychophysiological correlates of developmental changes in healthy and autistic boys /manager/Repository/uon:27424 Sat 24 Mar 2018 07:34:59 AEDT ]]> Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia /manager/Repository/uon:25812 postmortem brain tissue, and later in studies of peripheral blood. The collective body of schizophrenia microarray literature contains apparent inconsistencies between studies, with failures to replicate top hits, in part due to small sample sizes, cohort-specific effects, differences in array types, and other confounders. In an attempt to summarize existing studies of schizophrenia cases and non-related comparison subjects, we performed two mega-analyses of a combined set of microarray data from postmortem prefrontal cortices (n = 315) and from ex-vivo blood tissues (n = 578). We adjusted regression models per gene to remove non-significant covariates, providing best-estimates of transcripts dysregulated in schizophrenia. We also examined dysregulation of functionally related gene sets and gene co-expression modules, and assessed enrichment of cell types and genetic risk factors. The identities of the most significantly dysregulated genes were largely distinct for each tissue, but the findings indicated common emergent biological functions (e.g. immunity) and regulatory factors (e.g., predicted targets of transcription factors and miRNA species across tissues). Our network-based analyses converged upon similar patterns of heightened innate immune gene expression in both brain and blood in schizophrenia. We also constructed generalizable machine-learning classifiers using the blood-based microarray data. Our study provides an informative atlas for future pathophysiologic and biomarker studies of schizophrenia.]]> Sat 24 Mar 2018 07:34:35 AEDT ]]> CX3CR1 is dysregulated in blood and brain from schizophrenia patients /manager/Repository/uon:27390 Sat 24 Mar 2018 07:34:09 AEDT ]]> White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs /manager/Repository/uon:30942 Sat 24 Mar 2018 07:33:42 AEDT ]]> Schizophrenia risk from complex variation of complement component 4 /manager/Repository/uon:30050 Sat 24 Mar 2018 07:31:15 AEDT ]]> LD score regression distinguishes confounding from polygenicity in genome-wide association studies /manager/Repository/uon:28311 Sat 24 Mar 2018 07:27:06 AEDT ]]> Is it time to move mismatch negativity into the clinic? /manager/Repository/uon:24009 Sat 24 Mar 2018 07:16:46 AEDT ]]> Partitioning heritability by functional annotation using genome-wide association summary statistics /manager/Repository/uon:23306 Sat 24 Mar 2018 07:16:19 AEDT ]]> Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis /manager/Repository/uon:23305 Sat 24 Mar 2018 07:16:19 AEDT ]]> Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia /manager/Repository/uon:22172 Sat 24 Mar 2018 07:14:59 AEDT ]]> Brain imaging correlates of emerging schizophrenia /manager/Repository/uon:23563 Sat 24 Mar 2018 07:14:10 AEDT ]]> Mismatch negativity (MMN) as biomarker predicting psychosis in clinically at-risk individuals /manager/Repository/uon:24085 Sat 24 Mar 2018 07:11:47 AEDT ]]> Electrophysiological mismatch response recorded in awake pigeons from the avian functional equivalent of the primary auditory cortex /manager/Repository/uon:23992 Sat 24 Mar 2018 07:10:23 AEDT ]]> Effects of immune activation during early or late gestation on N-methyl-D-aspartate receptor measures in adult rat offspring /manager/Repository/uon:32572 Mon 23 Sep 2019 12:39:53 AEST ]]> Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring /manager/Repository/uon:33142 Mon 03 Sep 2018 12:55:09 AEST ]]> Intact sensorimotor gating in adult attention deficit hyperactivity disorder /manager/Repository/uon:6968 Mon 03 Feb 2020 10:35:05 AEDT ]]>