https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Nephrin - a biomarker of early glomerular injury https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18831 Wed 11 Apr 2018 09:37:04 AEST ]]> Cystatin C: a more reliable biomarker of renal function in young infants? A longitudinal cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38156 Wed 04 Aug 2021 18:23:49 AEST ]]> Retinal microvascular development in the first two years https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36685 in utero and early life insults and the development of chronic illness remains to be fully understood, but there is increasing data to indicate that microvasculature pathology plays an important mechanistic role. Currently available data indicate that retinal microvasculature changes are detectable in children as young as six years of age, however, there are no data for younger children. We present retinal microvasculature measurement from the first two years of life. Retinal images suitable for analysis were available from 18 infants in our proof-of-concept study. The mean and standard deviation (SD)for birth weight and gestation was 3410 (384)g and 39.1(1.4)weeks, respectively. Retinal vessel calibres were summarized as the mean(SD)central retinal arteriolar equivalent (CRAE)at six months of age was 156 (32)µm, increased to 175 (75)µm by 12 months and a slightly declined by 24 months of age to 168 (50)µm. In a similar pattern, mean(SD)central retinal venular equivalent (CRVE)at six months was 211 (19)µm, increased to 238 (25)µm by 12 months of age followed by a slight decline at 24 months of age to 222 (36)µm. The arterio-venous ratio and tortuosity index remained the same at 6, 12 and 24 months. Findings from this study could help future investigators better understand early microvasculature changes and adaptation that occur early in life.]]> Tue 23 Jun 2020 17:02:42 AEST ]]> Extra uterine development of preterm kidneys https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34951 Tue 03 Sep 2019 17:56:54 AEST ]]> An evaluation of preterm kidney size and function over the first two years of life https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36997 Thu 30 Jul 2020 16:38:14 AEST ]]> Female preterm indigenous Australian infants have lower renal volumes than males: a predisposing factor for end-stage renal disease? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37075 vs 21.4 (5.1) cm3; P = 0.027) despite no significant difference in body weight. Despite having a smaller TRV, there was no significant difference in eGFR between Indigenous and Non-indigenous neonates (47.8 [43.2-50.4] vs 46.2 [42.6-53.3] ml/min per 1.73 m2; P = 0.986). These infants achieve similar eGFR through hyperfiltration, which likely increases their future risk of CKD. There was no difference in microalbumin-creatinine ratio. Female Indigenous neonates, however, had significantly smaller TRV compared with Indigenous male neonates (15.9 (3.6) vs 20.6 (3.6) cm3; P = 0.006), despite no difference in eGFR, birth weight, gestational age, and weight at term corrected. Conclusion: The difference in TRV is likely to be an important risk factor for the difference in morbidity and mortality from renal disease reported between male and female Indigenous adults.]]> Thu 13 Aug 2020 15:42:43 AEST ]]> Evaluation of fetal kidney growth using ultrasound: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30441 Sat 24 Mar 2018 07:38:10 AEDT ]]> The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30848 Sat 24 Mar 2018 07:33:54 AEDT ]]> Biomarker of early glomerular injury in pre-eclampsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22880 Sat 24 Mar 2018 07:12:59 AEDT ]]> The lack of association between vascular endothelial growth factor and retinopathy of prematurity in an observational study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34950 Mon 27 May 2019 12:39:55 AEST ]]>