https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29580 BRCA1/2 mutations have a genetic predisposition for developing OC, but not all of these women develop the disease. Epidemiological findings show that lifestyle factors such as contraceptive use and pregnancy, a progesterone dominant state, decrease the risk of getting OC. How ovarian hormones modify the risk of OC is currently unclear. Our study identifies activated Wnt signalling to be a marker for precursor lesions of OC and successfully develops a mouse model that mimics the earliest events in pathogenesis of OC by constitutively activating ├čcatenin. Using this model and human OC cells, we show that oestrogen promotes and progesterone suppresses the growth of OC cells.]]> Wed 11 Apr 2018 17:04:27 AEST ]]> Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30999 Wed 11 Apr 2018 09:51:53 AEST ]]>