https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Lipid and metabolite deregulation in BRCA1 and BRCA2 genetic mutations: response https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24236 Wed 16 Nov 2016 14:36:47 AEDT ]]> Hitchhiker's guide to voxel segmentation for partial volume correction of in vivo magnetic resonance spectroscopy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24868 Wed 11 Apr 2018 16:46:08 AEST ]]> In Vivo brain magnetic resonance spectroscopy: a measurement of biomarker sensitivity to post-processing algorithms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21275 in vivo brain magnetic resonance spectroscopy biomarkers is investigated with respect to parameter values for two key stages of post-acquisitional processing. Our effort is specifically motivated by the lack of consensus on approaches and parameter values for the two critical operations, water resonance removal, and baseline correction. The different stages of data processing also introduce varying levels of uncertainty and arbitrary selection of parameter values can significantly underutilize the intrinsic differences between two classes of signals. The sensitivity of biomarkers points to the need for a better understanding of how all stages of post-acquisitional processing affect biomarker discovery and ultimately, clinical translation. Our results also highlight the possibility of optimizing biomarker discovery by the careful selection of parameters that best reveal class differences. Using previously reported data and biomarkers, our results demonstrate that small changes in parameter values affect the statistical significance and corresponding effect size of biomarkers. Consequently, it is possible to increase the strength of biomarkers by selecting optimal parameter values in different spectral intervals. Our analyses with a previously reported data set demonstrate an increase in effect sizes for wavelet-based biomarkers of up to 36%, with increases in classification performance of up to 12%.]]> Wed 11 Apr 2018 12:19:42 AEST ]]> Six fucose-alpha(1-2) sugars and alpha-fucose assigned in the human brain using in vivo two-dimensional MRS https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27115 Sat 24 Mar 2018 07:41:35 AEDT ]]> Lipid and metabolite deregulation in the breast tissue of women carrying BRCA1 and BRCA2 genetic mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27597 Sat 24 Mar 2018 07:25:17 AEDT ]]>