https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30189 Hfe−/−xTfr2mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.]]> Wed 11 Apr 2018 16:58:00 AEST ]]> Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease meuroimaging initiative (ADNI) plasma proteome dataset https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15120 Wed 11 Apr 2018 14:37:46 AEST ]]> Advantages of array-based technologies for pre-emptive pharmacogenomics testing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29574 Wed 11 Apr 2018 14:11:09 AEST ]]> Long-term mortality risks associated with mild anaemia in older persons: the Busselton health study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22222 10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. Conclusion: mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes.]]> Wed 11 Apr 2018 12:10:33 AEST ]]> Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4605 .05). Conclusion: Noncitrus fruits are environmental modifiers of iron status independent of HFE genotype. This could have important implications for the provision of evidence-based dietary advice to patients with other iron-storage disorders.]]> Wed 11 Apr 2018 09:47:07 AEST ]]> Evaluation of different normalization and analysis procedures for Illumina gene expression microarray data involving small changes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28613 Wed 11 Apr 2018 09:21:51 AEST ]]> Initial investigations of simple and multifactorial drug-gene interactions related to methotrexate in a community cohort https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32708 Thu 12 Jul 2018 12:19:18 AEST ]]> Preliminary analysis of potential drug and gene interactions involving tricyclic antidepressant drugs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32703 Thu 12 Jul 2018 11:51:28 AEST ]]> An introduction to the pharmacogenomics of oncology drugs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32702 Thu 12 Jul 2018 11:51:24 AEST ]]> Soluble lipoprotein receptor-related protein immunoreactive species in cell culture media and serum replacement supplements https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31487 Sat 24 Mar 2018 08:43:40 AEDT ]]> Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7033 Sat 24 Mar 2018 08:37:51 AEDT ]]> Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1596 Sat 24 Mar 2018 08:30:41 AEDT ]]> Insoluble α-synuclein in Alzheimer's disease without Lewy body formation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1370 Sat 24 Mar 2018 08:28:21 AEDT ]]> Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1747 Sat 24 Mar 2018 08:27:24 AEDT ]]> Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12514 Sat 24 Mar 2018 08:17:39 AEDT ]]> Hepatic iron loading in mice increases cholesterol biosynthesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10663 Sat 24 Mar 2018 08:12:41 AEDT ]]> A cross-sectional community study of serum iron measures and cognitive status in older adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10312 0.05). In participants without dementia (n=749), neither serum ferritin in 1994/5 or 2003/4 nor change in serum ferritin between these times was related to total CAMCOG or executive function scores, with or without adjustment for gender, age, National Adult reading test, or stroke history (all p> 0.05). No relationships were observed between ferritin and cognition for participants with possible or probable dementia (n=51). All participants identified as HFE C282Y homozygous or with serum ferritin >1,000 ng/ml had normal CAMCOG scores. We conclude abnormal body iron stores (low or high) are unlikely to have clinically significant effects on cognition or dementia risk in community-dwelling older people.]]> Sat 24 Mar 2018 08:12:22 AEDT ]]> Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10036 Sat 24 Mar 2018 08:12:16 AEDT ]]> Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10807 Sat 24 Mar 2018 08:11:50 AEDT ]]> Relationship between brain R₂ and liver and serum iron concentrations in elderly men https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10479 Sat 24 Mar 2018 08:09:15 AEDT ]]> Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20882 -/- mice, a model of hemochromatosis, relative to age- and gender-matched wildtype controls. Classification by functional pathway analysis revealed transcript changes for various genes important in AD. There were decreases of up to 9-fold in transcripts for amyloid-β protein precursor, tau, apolipoprotein E, presenilin 1, and various other γ-secretase components, as well as Notch signaling pathway molecules. This included decreased transcripts for 'hairy and enhancer of split' Hes1 and Hes5, downstream targets of Notch canonical signaling. The reductions in Hes1 and Hes5 transcripts provide evidence that the changes in levels of transcripts for γ-secretase components and Notch signaling genes have functional consequences. The effects appeared relatively specific for AD in that few genes pertaining to other important neurodegenerative diseases, notably Parkinson's disease and Huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. The observed effects on AD-related gene transcripts do not appear to be consistent with increased AD risk in HFE hemochromatosis and might, if anything, be predicted to protect against AD to some extent. As Hfe-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading.]]> Sat 24 Mar 2018 07:57:56 AEDT ]]> Beyond statistics: a new combinatorial approach to identifying biomarker panels for the early detection and diagnosis of Alzheimer's Disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17878 Sat 24 Mar 2018 07:56:13 AEDT ]]> Clinical perspectives on hereditary hemochromatosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5556 Sat 24 Mar 2018 07:49:12 AEDT ]]> Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25111 Sat 24 Mar 2018 07:17:15 AEDT ]]> Gene co-expression networks shed light into diseases of brain iron accumulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24321 Sat 24 Mar 2018 07:14:41 AEDT ]]> Role of iron in the pathogenesis of respiratory disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31006 Mon 23 Sep 2019 14:09:49 AEST ]]> Prevalence of clinically actionable genotypes and medication exposure of older adults in the community https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32706 Mon 23 Sep 2019 11:46:16 AEST ]]> Potential simple and multifactorial drug-gene interactions of tricyclic antidepressants in older Australians https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32298 Mon 23 Sep 2019 11:17:56 AEST ]]>