/manager/Index ${session.getAttribute("locale")} 5 The association of serum magnesium and mortality outcomes in heart failure patients: a systematic review and meta-analysis /manager/Repository/uon:25845 Wed 11 Apr 2018 18:51:26 AEST ]]> Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: a cross-sectional study on response to symptoms /manager/Repository/uon:14299 Wed 11 Apr 2018 17:07:41 AEST ]]> Is serum zinc level associated with prediabetes and diabetes?: A cross-sectional study from Bangladesh /manager/Repository/uon:15057 Wed 11 Apr 2018 16:51:17 AEST ]]> CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer /manager/Repository/uon:24073 -11). SNP rs727479 was also among those most strongly associated with circulating E₂ concentrations in 2767 post-menopausal controls (P=7.4x10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by the observed effect on E₂ concentrations (1.09, CI=1.03-1.21), consistent with the hypothesis that endometrial cancer risk is driven by E₂. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.]]> Wed 11 Apr 2018 16:40:46 AEST ]]> Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer /manager/Repository/uon:6849 Wed 11 Apr 2018 16:39:01 AEST ]]> Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the Hunter community study /manager/Repository/uon:16817 Wed 11 Apr 2018 15:56:18 AEST ]]> Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. /manager/Repository/uon:20561 Wed 11 Apr 2018 15:36:46 AEST ]]> Unhealthy lifestyle may increase later depression via inflammation in older women but not men /manager/Repository/uon:27319 Wed 11 Apr 2018 15:35:52 AEST ]]> Effect of lipophilic and hydrophilic statins on breast cancer risk in Thai women: a cross-sectional study /manager/Repository/uon:24983 Wed 11 Apr 2018 15:28:42 AEST ]]> Transsulfuration pathway thiols and methylated arginines: the hunter community study /manager/Repository/uon:14939 Wed 11 Apr 2018 15:21:27 AEST ]]> Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults /manager/Repository/uon:24759 -11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.]]> Wed 11 Apr 2018 15:04:20 AEST ]]> Efficacy of glucosamine plus diacerein versus monotherapy of glucosamine: a double-blind, parallel randomized clinical trial /manager/Repository/uon:23807 Wed 11 Apr 2018 15:03:55 AEST ]]> Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 /manager/Repository/uon:26195 Wed 11 Apr 2018 15:00:42 AEST ]]> Continuing difficulties in interpreting CNV data: lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients /manager/Repository/uon:14804 Wed 11 Apr 2018 14:46:12 AEST ]]> Fasting whole blood fatty acid profile and risk of type 2 diabetes in adults: a nested case control study /manager/Repository/uon:16813 Wed 11 Apr 2018 14:42:05 AEST ]]> The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations /manager/Repository/uon:27318 Wed 11 Apr 2018 14:21:46 AEST ]]> Colorectal cancer risk assessment and screening recommendation: a community survey of healthcare providers' practice from a patient perspective /manager/Repository/uon:14317 Wed 11 Apr 2018 14:17:15 AEST ]]> Association between hypertension and chronic arsenic exposure in drinking water: a cross-sectional study in Bangladesh /manager/Repository/uon:20106 50μg/L or to that of arsenic exposure as quartiles or as duration. Arsenic concentration as quartiles and >50 μg/L did show a strong relationship with increased pulse pressure (adjusted OR: 3.54, 95% CI: 1.46–8.57), as did arsenic exposure for ≥10 years (adjusted OR: 5.25, 95% CI: 1.41–19.51). Arsenic as quartiles showed a dose response relationship with increased pulse pressure. Our study suggests an association between higher drinking water arsenic or duration and pulse pressure, but not hypertension.]]> Wed 11 Apr 2018 14:04:17 AEST ]]> Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: systematic review and meta-analysis /manager/Repository/uon:25809 Wed 11 Apr 2018 13:52:40 AEST ]]> Is higher consumption of animal flesh foods associated with better iron status among adults in developed countries? A systematic review /manager/Repository/uon:24574 Wed 11 Apr 2018 13:27:00 AEST ]]> Meta-analysis of cytokine gene polymorphisms and outcome of heart transplantation /manager/Repository/uon:20808 Wed 11 Apr 2018 12:16:47 AEST ]]> Association between type 2 diabetes and chronic arsenic exposure in drinking water: a cross sectional study in Bangladesh /manager/Repository/uon:20351 Wed 11 Apr 2018 12:14:21 AEST ]]> Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children /manager/Repository/uon:30108 Wed 11 Apr 2018 12:12:57 AEST ]]> Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults /manager/Repository/uon:16952 Wed 11 Apr 2018 11:49:10 AEST ]]> Biochemical validation of the older Australian's food frequency questionnaire using carotenoids and vitamin E /manager/Repository/uon:16953 Wed 11 Apr 2018 11:42:24 AEST ]]> Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis /manager/Repository/uon:21811 Wed 11 Apr 2018 11:28:19 AEST ]]> Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis /manager/Repository/uon:16786 Wed 11 Apr 2018 11:23:35 AEST ]]> Genome-wide association study of endometrial cancer in E2C2 /manager/Repository/uon:20989 Wed 11 Apr 2018 11:20:08 AEST ]]> The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor /manager/Repository/uon:4378 A, causes overexpression and supports uncontrollable cellular growth. This polymorphism has been associated with an increased risk of developing many cancers, including endometrial cancer. Methods: The 870 G>A polymorphisms (rs605965) in the cyclin D1 gene was genotyped in an Australian endometrial cancer case-control population including 191 cases and 291 controls using real-time PCR analysis. Genotype analysis was performed using chi-squared (χ²) statistics and odds ratios were calculated using unconditional logistic regression, adjusting for potential endometrial cancer risk factors. Results: Women homozygous for the variant cyclin D1 870 AA genotype showed a trend for an increased risk of developing endometrial cancer compared to those with the wild-type GG genotype, however this result was not statistically significant (OR 1.692 95% CI (0.939-3.049), p = 0.080). Moreover, the 870 G>A polymorphism was significantly associated with family history of colorectal cancer. Endometrial cancer patients with the homozygous variant AA genotype had a higher frequency of family members with colorectal cancer in comparison to endometrial cancer patients with the GG and combination of GG and GA genotypes (GG versus AA; OR 2.951, 95% CI (1.026-8.491), p = 0.045, and GG+GA versus AA; OR 2.265, 95% CI (1.048-4.894), p = 0.038, respectively). Conclusion: These results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer. A more complex relationship was observed between this polymorphism and familial colorectal cancer.]]> Wed 11 Apr 2018 10:44:26 AEST ]]> Individual- and provider-level factors associated with colorectal cancer screening in accordance with guideline recommendation: a community-level perspective across varying levels of risk /manager/Repository/uon:14022 Wed 11 Apr 2018 10:41:43 AEST ]]> Genetic feedback to reduce alcohol consumption in hospital outpatients with risky drinking: feasibility and acceptability /manager/Repository/uon:25770 Wed 11 Apr 2018 10:27:04 AEST ]]> Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health /manager/Repository/uon:14444 Wed 11 Apr 2018 10:07:56 AEST ]]> Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk /manager/Repository/uon:9714 Wed 11 Apr 2018 09:43:06 AEST ]]> Availability of arsenic in human milk in women and its correlation with arsenic in urine of breastfed children living in arsenic contaminated areas in Bangladesh /manager/Repository/uon:16780 Wed 11 Apr 2018 09:14:25 AEST ]]> Plasma apolipoproteins and physical and cognitive health in very old individuals /manager/Repository/uon:34724 Wed 04 Sep 2019 09:54:37 AEST ]]> Progression of chronic kidney disease: an illness-death model approach /manager/Repository/uon:30809 Wed 02 Oct 2019 10:27:56 AEST ]]> Performance of screening questionnaires for obstructive sleep apnea during pregnancy: a systematic review and meta-analysis /manager/Repository/uon:31550 I2 = 83.15%). BQ performance was poor to fair with pooled sensitivity and specificity of 0.66 (95%CI: 0.45, 0.83; I2 = 78.65%) and 0.62 (95%CI: 0.48, 0.75; I2 = 81.55%), respectively. BQ performance was heterogeneous depending on type of reference test and pregnancy. Sensitivity increased if diagnosis was based on polysomnography (0.90), and respiratory disturbance index (0.90). However, sensitivity decreased if screening was performed in early pregnancy (≤20 weeks gestation: 0.47), and high-risk pregnancy (0.44). Performance of ESS was poor with pooled sensitivity and specificity of 0.44 (95%CI: 0.33, 0.56; I2 = 32.8%) and 0.62 (95%CI: 0.48, 0.75; I2 = 81.55%), respectively. In conclusion, BQ and ESS showed poor performance during pregnancy, hence a new OSA screening questionnaire is needed.]]> Wed 02 Oct 2019 10:27:36 AEST ]]> Evaluation of rational nonsteroidal anti-inflammatory drugs and gastro-protective agents use; association rule data mining using outpatient prescription patterns /manager/Repository/uon:30415 Wed 02 Oct 2019 10:27:18 AEST ]]> Effects of education and income on cardiovascular outcomes: a systematic review and meta-analysis /manager/Repository/uon:34723 Tue 03 Sep 2019 18:30:51 AEST ]]> Environmental tobacco smoke and peripheral arterial disease: a review /manager/Repository/uon:30531 Tue 03 Sep 2019 18:30:34 AEST ]]> The protective effect of muesli consumption on diabetes risk: results from 12 years of follow-up in the Australian Longitudinal Study on Women's Health /manager/Repository/uon:34931 20,000 kJ. Logistic regression with discrete time survival analyses investigated the association between breakfast cereal intake and incident diabetes. Models were adjusted for income, BMI, smoking, physical activity, education, and dietary intakes and included a measure of time. There were 637 incident cases of diabetes. Breakfast cereal intake per se was not associated with incident diabetes (OR: 1.00; P =.98). Muesli consumption on its own (OR: 0.74; P =.00) or as a part of oats-based cereal (OR: 0.84; P =.047) was significantly associated with a decrease in the odds of developing diabetes. No other breakfast cereals were significantly associated with diabetes risk. Among mid-aged Australian women, muesli consumption was associated with a reduction in diabetes risk. This effect may be due to a particular profile of muesli eaters, but the relationship warrants further investigation.]]> Tue 03 Sep 2019 18:19:37 AEST ]]> Neutrophil lymphocyte ratio and cardiovascular disease risk: a systematic review and meta-analysis /manager/Repository/uon:34942 Tue 03 Sep 2019 17:57:11 AEST ]]> Breakfast cereal consumption and obesity risk amongst the mid-age cohort of the Australian Longitudinal Study on Women's Health /manager/Repository/uon:30120 20,000 kJ/day, or they reported being overweight or obese at S3. Logistic regressions with discrete time survival analysis investigated the association between breakfast cereal intake and incident obesity and were adjusted for: area of residency, income, smoking, physical activity, hypertension, dietary intakes and a discrete measure of time. There were 308 incident cases of obesity. Any breakfast cereal intake was not associated with incident obesity (Odds Ratio (OR): 0.92; p = 0.68). Oat-based cereal (OR: 0.71; p = 0.01), muesli (OR: 0.57; p = 0.00) and All-Bran (OR: 0.62; p = 0.01) intakes were associated with a significant reduction in obesity risk. Among this cohort, muesli on its own, or as part of oat-based cereals, and All-Bran, were associated with a reduction in obesity. This effect may be due to particular characteristics of these cereal eaters, but the relationship warrants further investigation.]]> Tue 02 Apr 2019 14:06:34 AEDT ]]> Calcium and vitamin D supplementation for prevention of preeclampsia: a systematic review and network meta-analysis /manager/Repository/uon:30456 Tue 01 May 2018 09:15:25 AEST ]]> Comparison of superficial surgical site infection between delayed primary versus primary wound closure in complicated appendicitis: a randomized controlled trial /manager/Repository/uon:36199 Thu 27 Feb 2020 13:40:32 AEDT ]]> Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function /manager/Repository/uon:35094 Thu 20 Jun 2019 15:56:20 AEST ]]> Comparative efficacy of lifestyle intervention strategies targeting weight outcomes in people with psychosis: A systematic review and network meta-analysis /manager/Repository/uon:37352 Thu 15 Oct 2020 13:23:33 AEDT ]]> Common variants at 6p21.1 are associated with large artery atherosclerotic stroke /manager/Repository/uon:13951 Sat 24 Mar 2018 10:41:26 AEDT ]]> How to use an article about genetic association. C: what are the results and will they help me in caring for my patients? /manager/Repository/uon:7492 Sat 24 Mar 2018 08:37:45 AEDT ]]> How to use an article about genetic association. B: are the results of the study valid? /manager/Repository/uon:7490 Sat 24 Mar 2018 08:37:45 AEDT ]]> How to use an article about genetic association. A: background concepts /manager/Repository/uon:7491 Sat 24 Mar 2018 08:37:45 AEDT ]]> Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk /manager/Repository/uon:9354 Sat 24 Mar 2018 08:36:33 AEDT ]]> A systematic review and meta-analysis of tumor necrosis factor α-308 polymorphism and Kawasaki disease /manager/Repository/uon:9346 Sat 24 Mar 2018 08:36:28 AEDT ]]> Cohort profile: the Hunter Community Study /manager/Repository/uon:9648 60 years is growing faster than any other age group and is expected to reach 2 billion worldwide by 2050. Internationally and nationally, considerable efforts are being made to promote active ageing. However, Australia lacks the kind of comprehensive longitudinal research underway in Europe and North America. Although Australia does have a number of longitudinal studies designed to address various issues of health and ageing among older adults, only a few of these studies include a broad and comprehensive range of physical and biological measures. The Hunter Community Study (HCS) is a collaborative study between the University of Newcastle’s School of Medicine and Public Health and the Hunter New England Area Health Service. It is a multi disciplinary initiative that was established to fill some existing gaps in ageing research in Australia and is unique in that it has collected detailed information across all six key policy themes as identified in the Framework for an Australian Ageing Research Agenda.]]> Sat 24 Mar 2018 08:35:25 AEDT ]]> Systematic review and meta-analysis of the association between complementary factor HY402H polymorphisms and age-related macular degeneration /manager/Repository/uon:1066 Sat 24 Mar 2018 08:32:10 AEDT ]]> Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis /manager/Repository/uon:1029 Sat 24 Mar 2018 08:31:54 AEDT ]]> Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review /manager/Repository/uon:1555 Sat 24 Mar 2018 08:30:45 AEDT ]]> Exploring new frontiers in occupational epidemiology: the Hunter Community Study (HCS) from Australia /manager/Repository/uon:11376 Sat 24 Mar 2018 08:11:55 AEDT ]]> The Audio Recorded Cognitive Screen (ARCS): a flexible hybrid cognitive test instrument /manager/Repository/uon:11471 Sat 24 Mar 2018 08:11:39 AEDT ]]> Efficacy and adverse events of mycophenolate mofetil versus cyclophosphamide for induction therapy of lupus nephritis: systematic review and meta-analysis /manager/Repository/uon:11389 Sat 24 Mar 2018 08:10:00 AEDT ]]> Higher unprocessed red meat, chicken and fish intake is associated with a higher vegetable intake in mid-age non-vegetarian women /manager/Repository/uon:21422 P < 0.001), red meat (RC = 0.45, 95% CI: 0.42–0.48; P < 0.001), chicken (RC = 0.78, 95% CI: 0.70–0.85; P < 0.001) and fish intake (RC = 0.48, 95% CI: 0.42–0.53; P < 0.001) were significantly associated with higher vegetable intakes after adjusting for confounders. The adjusted R2 values for each of the regression models were relatively small (0.1590, 0.1394, 0.0932, 0.0802), indicating that the included predictors did not account for much of the variation in vegetable intake. Conclusion: These results provide some evidence that higher intakes of unprocessed red meat, chicken and fish are associated with higher intakes of vegetables. This supports the notion that many Australians who are serving up unprocessed red meat, chicken or fish for their meals are also consuming a number of vegetable serves.]]> Sat 24 Mar 2018 08:05:02 AEDT ]]> Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis /manager/Repository/uon:18169 Sat 24 Mar 2018 08:04:35 AEDT ]]> Management of chronic prostatitis/ chronic pelvic pain syndrome: a systematic review and network meta-analysis /manager/Repository/uon:18172 Sat 24 Mar 2018 08:04:34 AEDT ]]> Spirituality, religion, social support and health among older Australian adults /manager/Repository/uon:18171 Sat 24 Mar 2018 08:04:34 AEDT ]]> Autoantibodies and depression: evidence for a causal link? /manager/Repository/uon:20858 Sat 24 Mar 2018 08:02:51 AEDT ]]> Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts. /manager/Repository/uon:18764 Sat 24 Mar 2018 08:02:46 AEDT ]]> The association between cytokine gene polymorphisms and graft rejection in liver transplantation: a systematic review and meta-analysis /manager/Repository/uon:19469 Sat 24 Mar 2018 08:02:22 AEDT ]]> Diet quality score is a predictor of type 2 diabetes risk in women: the Australian longitudinal study on women's health /manager/Repository/uon:19446 Sat 24 Mar 2018 08:02:17 AEDT ]]> Concordance between direct and imputed APOE genotypes using 1000 genomes data /manager/Repository/uon:19672 Sat 24 Mar 2018 08:01:12 AEDT ]]> A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults /manager/Repository/uon:16922 Sat 24 Mar 2018 08:00:31 AEDT ]]> Tenascin-C is increased in atherothrombotic stroke patients and has an anti-inflammatory effect in the human carotid artery /manager/Repository/uon:20732 Sat 24 Mar 2018 08:00:27 AEDT ]]> Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium /manager/Repository/uon:20501 Sat 24 Mar 2018 07:59:03 AEDT ]]> The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis /manager/Repository/uon:20368 Sat 24 Mar 2018 07:58:11 AEDT ]]> Memory impairment is associated with serum methylarginines in older adults /manager/Repository/uon:17876 Sat 24 Mar 2018 07:56:43 AEDT ]]> Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome /manager/Repository/uon:20622 Sat 24 Mar 2018 07:55:47 AEDT ]]> The efficacy of zinc supplementation in depression: systematic review of randomised controlled trials /manager/Repository/uon:20304 Sat 24 Mar 2018 07:55:12 AEDT ]]> Macronutrient intake and type 2 diabetes risk in middle-aged Australian women: results from the Australian Longitudinal Study on Women's Health /manager/Repository/uon:19183 Sat 24 Mar 2018 07:55:03 AEDT ]]> Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence /manager/Repository/uon:20967 Sat 24 Mar 2018 07:54:23 AEDT ]]> Macronutrient intakes and development of type 2 diabetes: a systematic review and meta-analysis of cohort studies /manager/Repository/uon:21644 Sat 24 Mar 2018 07:52:20 AEDT ]]> Predictors of suicidal ideation in older people: a decision tree analysis /manager/Repository/uon:19175 Sat 24 Mar 2018 07:52:17 AEDT ]]> Hemoglobin concentration and pregnancy outcomes: a systematic review and meta-analysis /manager/Repository/uon:19422 Sat 24 Mar 2018 07:51:58 AEDT ]]> Polygenic overlap between kidney function and large artery atherosclerotic stroke /manager/Repository/uon:19418 Sat 24 Mar 2018 07:51:57 AEDT ]]> Diagnostic scores for appendicitis: a systematic review of scores' performance /manager/Repository/uon:19321 Sat 24 Mar 2018 07:51:55 AEDT ]]> Genome-wide analysis of blood pressure variability and ischemic stroke /manager/Repository/uon:20171 Sat 24 Mar 2018 07:51:43 AEDT ]]> Genetics of hand grip strength in mid to late life /manager/Repository/uon:21021 N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.]]> Sat 24 Mar 2018 07:50:32 AEDT ]]> Genome-wide association meta-analysis identifies new endometriosis risk loci /manager/Repository/uon:21532 −3), and we confirm association of rs7521902 at 1p36.12 near WNT4. In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). Excluding cases of European ancestry of minimal or unknown severity, we identified additional previously unknown loci at 2p14 (rs4141819), 6p22.3 (rs7739264) and 9p21.3 (rs1537377). All seven SNP effects were replicated in an independent cohort and associated at P <5 × 10−8 in a combined analysis. Finally, we found a significant overlap in polygenic risk for endometriosis between the genome-wide association cohorts of European and Japanese descent (P = 8.8 × 10−11), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations.]]> Sat 24 Mar 2018 07:50:27 AEDT ]]> Association between endometriosis and the interleukin 1A (IL1A) locus /manager/Repository/uon:26880 -8). Limitations, Reasons for Caution: The meta-analysis for moderate-to-severe endometriosis included results of moderate-to-severe endometriosis cases from our European data sets and all endometriosis cases from the Japanese data sets, as disease stage information was not available for endometriosis cases in the Japanese data sets. Wider Implications of the Findings: SNP rs6542095 is located ~2.3 kb downstream of the IL1A gene and ~6.9 kb upstream of cytoskeleton-associated protein 2-like (CKAP2L) gene. The IL1A gene encodes the IL1a protein, a member of the interleukin 1 cytokine family which is involved in various immune responses and inflammatory processes. These results provide important replication in an independent Japanese sample and, for the first time, association of the IL1A locus in endometriosis patients of European ancestry. SNPs within the IL1A locus may regulate other genes, but if IL1A is the target, our results provide supporting evidence for a link between inflammatory responses and the pathogenesis of endometriosis. Study Funding/Competing Interest(s): The research was funded by grants from the Australian National Health and Medical Research Council and Wellcome Trust. None of the authors has competing interests for the study.]]> Sat 24 Mar 2018 07:41:44 AEDT ]]> Genetic burden associated with varying degrees of disease severity in endometriosis /manager/Repository/uon:28053 Sat 24 Mar 2018 07:41:03 AEDT ]]> Treatment effects of renin-angiotensin aldosterone system blockade on kidney failure and mortality in chronic kidney disease patients /manager/Repository/uon:31991 1 year (RAAS2). An augmented inverse-probability weighting (AIPW) method was used to estimate potential-outcome mean (POM) and average treatment-effect (ATE). Multi-logit and Poisson regressions were used for treatment and outcome models, respectively. Analyses were stratified by ESRD, death before/after ESRD for diabetic and non-diabetic groups. STATA 14.0 was used for statistical analyses. Results: Among 15,032 diabetic patients, 2346 (15.6%), 2351 (18.5%), and 1607 (68.5%) developed ESRD, died before ESRD, and died after ESRD, respectively. Only RAAS2 effect was significant on ESRD, death before and after ESRD. The ESRD rates were 12.9%, versus 20.0% for RAAS2 and non-RAAS, respectively, resulted in significant risk differences (RD) of -7.2% (95% CI: -8.8%, -5.5%), and a numbers needed-to-treat (NNT) of 14. Death rates before ESRD for these corresponding groups were 14.4% (12.9%, 15.9%) and 19.6% (18.7%, 20.4%) with a NNT of 19. Death rates after ESRD in RAAS2 was lower than non-RASS group (i.e., 62.8% (55.5%, 68.9%) versus 68.1% (65.9%, 70.4%)) but this was not significant. RAAS2 effects on ESRD and death before ESRD were persistently significant in non-diabetic patients (n = 17,074) but not for death after ESRD with the NNT of about 15 and 16 respectively. Conclusions: Receiving RAAS blockade for 1 year or longer could prevent both CKD progression to ESRD and premature mortality.]]> Mon 23 Sep 2019 13:22:31 AEST ]]> Cardiovascular disease lifestyle risk factors in people with psychosis: a cross-sectional study /manager/Repository/uon:32807 Mon 23 Sep 2019 13:13:42 AEST ]]> Prospective study of dietary zinc intake and risk of cardiovascular disease in women /manager/Repository/uon:32803 Mon 23 Sep 2019 11:56:47 AEST ]]> Health and ageing data from the Hunter Community Study, NSW, Australia /manager/Repository/uon:8539 Mon 23 Sep 2019 11:55:24 AEST ]]> A serological diagnosis of coeliac disease is associated with osteoporosis in older Australian adults /manager/Repository/uon:32805 Mon 23 Sep 2019 10:39:48 AEST ]]> Assessment of nutritional status of infants living in arsenic-contaminated areas in Bangladesh and its association with arsenic exposure /manager/Repository/uon:32802 Mon 23 Sep 2019 10:24:09 AEST ]]> The role of inorganic nitrate and nitrite in CVD /manager/Repository/uon:31134 Mon 17 Dec 2018 10:01:01 AEDT ]]> Social dysfunction and diet outcomes in people with psychosis /manager/Repository/uon:26111 Mon 03 Feb 2020 10:25:11 AEDT ]]> Dietary long-chain fatty acids and cognitive performance in older Australian adults /manager/Repository/uon:35710 4.5 but <20.0MJ/d). Linear regression models showed statistically significant associations between dietary intake of total n-6 fatty acids and improved cognitive performance measured by the ARCs (RC= 0.0043; P=0.0004; R²= 0.0084). Quartiles of n-6 fatty acid intakes where the lowest quartile of n-6 fatty acid intake (179.8-1150.3mg) and those in the highest quartile (2315.0-7449.4mg) had a total ARCs score 10.6 units greater (RC= 10.60466; P= 0.006; R²= 0.0081). Furthermore, when n-6 fatty acid intake was tested against each of the ARCs domains, statistically significant associations were observed for the Fluency (RC=0.0011432; P= 0.007; R²=0.0057), Visual (RC=0.0009889;P=0.034;R²=0.0050), Language (RC=0.0010651; P=0.047;R²=0.0068) and Attention (RC=0.0011605; P=0.017; R²=0.0099) domains, yet there was no association with Memory (RC= -0.000064; P= 0.889; R²= 0.0083). No statistically significant associations between any other fatty acids and ARCS, nor any fatty acids and MMSE were detected. A higher intake of total n-6 fatty acid, but no other types of fatty acids, was associated with better cognitive performance among a representative sample of older Australian adults.]]> Fri 25 Oct 2019 15:40:12 AEDT ]]> Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial /manager/Repository/uon:36636 Fri 19 Jun 2020 11:46:42 AEST ]]> Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders /manager/Repository/uon:37079 Fri 14 Aug 2020 10:26:50 AEST ]]> Prospective study on the association between diet quality and depression in mid-aged women over 9 years /manager/Repository/uon:32492 Fri 08 Jun 2018 14:22:16 AEST ]]>