/manager/Index ${session.getAttribute("locale")} 5 Ongoing increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: a 50-year study /manager/Repository/uon:33281 Tue 25 Sep 2018 11:08:20 AEST ]]> 2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> Anxiety levels are independently associated with cognitive performance in an Australian multiple sclerosis patient cohort /manager/Repository/uon:31520 Sat 24 Mar 2018 08:43:53 AEDT ]]> A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis /manager/Repository/uon:24704 85% loss of 'pore' function of the P2X7 receptor measured by ATP-induced ethidium uptake. Analysis shows Arg307Gln always occurred with 270His suggesting a single 307Gln-270His haplotype which confers dominant negative effects on P2X7 function and protection against MS. Modelling based on the homologous zP2X4 receptor showed Arg307 is located in a region rich in basic residues located only 12Å from the ligand binding site. Our data show the protective effect against MS of a rare genetic variant of P2RX7 with heterozygotes showing near absent proinflammatory 'pore' function.]]> Sat 24 Mar 2018 07:10:52 AEDT ]]>