https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genome-wide association study of retinopathy in individuals without diabetes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15067 Wed 11 Apr 2018 16:52:00 AEST ]]> Genetic loci for retinal arteriolar microcirculation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15066 Wed 11 Apr 2018 14:58:51 AEST ]]> Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15068 Wed 11 Apr 2018 13:50:10 AEST ]]> Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9569 Wed 11 Apr 2018 13:25:58 AEST ]]> Retinal arteriolar narrowing is associated with 5-year incident severe hypertension: the Blue Mountains Eye Study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1444 Wed 11 Apr 2018 10:39:52 AEST ]]> Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8430 Sat 24 Mar 2018 08:40:46 AEDT ]]> Risk factors for incident age-related macular degeneration: pooled findings from 3 continents https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1896 Sat 24 Mar 2018 08:33:07 AEDT ]]> Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12709 Sat 24 Mar 2018 08:16:20 AEDT ]]> Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21315 P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions.]]> Sat 24 Mar 2018 07:52:47 AEDT ]]> Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28356 −9) in a combined discovery and replication set (26 953 samples). This single nucleotide polymorphism (SNP) is located within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range of alternative splicing events implicated in neuronal development and maturation, including transcription factors, other splicing factors and synaptic proteins.]]> Sat 24 Mar 2018 07:25:12 AEDT ]]> Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the three continent AMD consortium report https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31934 complement factor H and age-related maculopathy susceptibility 2 genes (compared with none, OR 1.76 for 1 risk allele and OR 3.34 for 2+ risk alleles), smoking (compared with non-smokers, OR 1.64 for past and OR 1.67 for current smokers), and the presence of large drusen area or retinal pigmentary abnormalities in the first eye. Conclusion: One in four to one in five unilateral any AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.]]> Mon 09 Apr 2018 11:32:09 AEST ]]> Prediction of age-related macular degeneration in the general population: the three continent AMD consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18788 Fri 15 May 2020 06:43:18 AEST ]]>