/manager/Index ${session.getAttribute("locale")} 5 Alterations of placental vascular function in asthmatic pregnancies /manager/Repository/uon:1310 0.05). Corticotropin-releasing hormone (CRH), a potent vasodilator that acts via the nitric oxide pathway, caused a dose-dependent vasodilatory response in all placentae in vitro. However, CRH-induced dilation was significantly reduced in moderate and severe asthmatics (ANOVA, p < 0.05). Vasoconstrictor responses to potassium chloride and prostaglandin F2alpha were reduced in placentae from moderate and severe asthmatic women (ANOVA, p < 0.05). These studies demonstrate significant differences in placental vascular function in pregnancies complicated by asthma, which may relate directly to the asthma or be a consequence of the associated glucocorticoid treatment. These changes in vascular function in asthmatic pregnancies may contribute to the low-birthweight outcome observed in this condition.]]> Sat 24 Mar 2018 08:32:42 AEDT ]]> Maternal asthma is associated with reduced female fetal growth /manager/Repository/uon:1792 Sat 24 Mar 2018 08:27:30 AEDT ]]>