/manager/Index ${session.getAttribute("locale")} 5 Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes. /manager/Repository/uon:18545 Wed 11 Apr 2018 12:52:16 AEST ]]> Frequency of folate-related polymorphisms varies by skin pigmentation /manager/Repository/uon:37803 MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases. Results: A significant association between variant frequency and Fitzpatrick phototype was observed for 16 of 17 examined variants (P<.0029 Bonferroni corrected significance threshold in all cases). Conclusions: These findings demonstrate novel relationships between skin color and folate-related genes, with trends suggesting folate genotypes are selected to maintain homeostasis in the folate system under differing UVR conditions.]]> Mon 26 Apr 2021 11:48:42 AEST ]]>