/manager/Index ${session.getAttribute("locale")} 5 MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer /manager/Repository/uon:10386 Wed 11 Apr 2018 17:00:11 AEST ]]> MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer /manager/Repository/uon:8339 T and 1298 A>C, that alter the function of the encoded protein have been the focus of many studies on CRC risk outside the context of an inherited predisposition to disease. In this report, a total of 417 HNPCC participants were genotyped for the 677 C>T and 1298 A>C SNPs to determine whether there exists an association with the age of disease onset of CRC. Genotyping of both SNPs was performed by TaqMan assay technology. Associations in disease risk were further investigated using Kaplan–Meier survival analysis and Cox hazard regression. The average ages of disease diagnosis were found to be different between individuals harbouring either one of the MTHFR polymorphisms. Both Kaplan–Meier and Cox hazard regression analyses revealed a more complex relationship between the two polymorphisms and the age of CRC onset. The Kaplan–Meier survival analysis revealed that compound heterozygotes for the two SNPs developed CRC 10 years later compared with those carrying only wild-type alleles.]]> Sat 24 Mar 2018 08:39:40 AEDT ]]> Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age /manager/Repository/uon:7033 Sat 24 Mar 2018 08:37:51 AEDT ]]> Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations /manager/Repository/uon:1747 Sat 24 Mar 2018 08:27:24 AEDT ]]> Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome /manager/Repository/uon:14315 Sat 24 Mar 2018 08:24:40 AEDT ]]> DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome /manager/Repository/uon:20280 Sat 24 Mar 2018 07:59:53 AEDT ]]> Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers /manager/Repository/uon:23143 Sat 24 Mar 2018 07:10:33 AEDT ]]>