/manager/Index ${session.getAttribute("locale")} 5 RAB-Like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly /manager/Repository/uon:15139 Wed 11 Apr 2018 14:39:08 AEST ]]> RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility /manager/Repository/uon:14944 Wed 11 Apr 2018 14:30:16 AEST ]]> Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation /manager/Repository/uon:22277 Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies, and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation, a common disturbance of atypical clinical immune deficiencies.]]> Sat 24 Mar 2018 07:17:41 AEDT ]]>