/manager/Index ${session.getAttribute("locale")} 5 CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer /manager/Repository/uon:24073 -11). SNP rs727479 was also among those most strongly associated with circulating E₂ concentrations in 2767 post-menopausal controls (P=7.4x10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by the observed effect on E₂ concentrations (1.09, CI=1.03-1.21), consistent with the hypothesis that endometrial cancer risk is driven by E₂. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.]]> Wed 11 Apr 2018 16:40:46 AEST ]]> Five endometrial cancer risk loci identified through genome-wide association analysis /manager/Repository/uon:27984 Sat 24 Mar 2018 07:38:42 AEDT ]]> Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer /manager/Repository/uon:26799 Sat 24 Mar 2018 07:36:26 AEDT ]]>