https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35661 −1, p < 0.0001), LDL-C (−0.49 mmol L−1, p < 0.0001) and CVD risk (−1.1 absolute %, p = 0.0005) compared to the PL-C group. Reductions from baseline in the PS-C group compared to that in the PL-C group were 7.6% and 10.6% for TC and LDL-C, respectively, and statistically significant (p < 0.0001). CVD-risk in the PS-C group reduced significantly (−12.7%) compared to that in the PL-C group (p = 0.0005). HDL-C and TG remained unchanged. The LDL-P number significantly decreased in the PS-C group by 124.33 nmol L−1 compared to that in the PL-C group (p = 0.005) and both groups showed a significant decrease in LDL-P size (p < 0.01); however, the absolute nm change in LDL-P size did not differ between groups and the percent change in LDL-P size in the PS-C group was borderline significant (−0.89%, p = 0.05) compared to that in the PL-C group. Regular consumption of PS-enriched bread with or without curcumin lowers blood cholesterol; however, curcumin alone did not influence blood lipids. Bread may be a convenient means of delivering PS with greater compliance for reducing the blood cholesterol concentration.]]> Wed 24 Jun 2020 11:00:42 AEST ]]> InsuTAG: a novel physiologically relevant predictor for insulin resistance and metabolic syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30774 Wed 11 Apr 2018 11:53:38 AEST ]]> Fat type in phytosterol products influence their cholesterol-lowering potential: a systematic review and meta-analysis of RCTs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27931 Wed 02 Oct 2019 13:19:54 AEST ]]> Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: biochemical effects vs. clinical outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35660 Wed 02 Oct 2019 13:05:55 AEST ]]> Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33436 Tue 04 Jun 2019 12:44:34 AEST ]]> High molecular weight oat ß-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37181 n = 18) or 2 g PS (PS, n = 18), 3 g OBG (OBG, n = 18), or combination of 2 g PS and 3 g OBG (PS-OBG, n = 18) per day for 6 weeks. Primary outcome was fasting plasma total cholesterol (TC) and secondary outcomes were LDL-cholesterol, LDL-C; HDL-cholesterol, HDL-C; triglycerides, TG and TC to HDL-cholesterol (TC:HDL) ratio. Results: TC and LDL-C were significantly lowered following PS (-4.6% and -7.6% respectively; p < 0.05), OBG (-5.7% and -8.6%; p < 0.01) and PS-OBG (-11.5% and -13.9%; p < 0.0001) administration. The reduction in TC in the PS-OBG group was significantly greater compared to PL (p < 0.001) and PS (p < 0.05). PS-OBG group had a significantly greater reduction in LDL-C compared to PL (p < 0.01) but not in comparison to PS or OBG groups. TC:HDL ratio was significantly reduced following PS-OBG (-8.9%; p < 0.01) only, and there was no significant difference found between groups. Plasma TG reduced by 8.4% following PS-OBG, however, this was statistically non-significant. Plasma HDL-C remained unchanged across all groups. Conclusions: Dietary supplementation with high-MW OBG and PS in a single functional food enhances their lipid-lowering potential. Blood cholesterol lowering by PS and OBG is additive. Delivery of these two bioactive nutrients in a single food allows optimisation of their lipid-lowering effects and may provide added heart health benefits with enhanced compliance. The trial was registered with the Australian New Zealand Clinical Trials Registry at http://www.anzctr.org.au/(ACTRN12618001455257).]]> Thu 27 Aug 2020 11:45:31 AEST ]]> Association between omega-3 index and blood lipids in older Australians https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24083 Fri 13 Sep 2019 15:11:36 AEST ]]>