/manager/Index ${session.getAttribute("locale")} 5 Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations /manager/Repository/uon:21315 P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions.]]> Sat 24 Mar 2018 07:52:47 AEDT ]]> Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the three continent AMD consortium report /manager/Repository/uon:31934 complement factor H and age-related maculopathy susceptibility 2 genes (compared with none, OR 1.76 for 1 risk allele and OR 3.34 for 2+ risk alleles), smoking (compared with non-smokers, OR 1.64 for past and OR 1.67 for current smokers), and the presence of large drusen area or retinal pigmentary abnormalities in the first eye. Conclusion: One in four to one in five unilateral any AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.]]> Mon 09 Apr 2018 11:32:09 AEST ]]> Prediction of age-related macular degeneration in the general population: the three continent AMD consortium /manager/Repository/uon:18788 Fri 15 May 2020 06:43:18 AEST ]]>