Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

- Grosche, Sarah, Marenholz, Ingo, Bisgaard, Hans, Bønnelykke, Klaus, Brown, Sara J., Bustamante, Mariona, Curtin, John A., Custovic, Adnan, Dharmage, Shyamali C., Esplugues, Ana, Falchi, Mario, Fernandez-Orth, Dietmar, Esparza-Gordillo, Jorge, Ferreira, Manuel A. R., Franke, A, Gerdes, S, Gieger, C, Hakonarson, H, Holt, PG, Homuth, G, Hubner, N, Hysi, PG, Jarvelin, M-R, Arnau-Soler, Aleix, Karlsson, R, Koppelman, GH, Lau, S, Lutz, M, Magnusson, PKE, Marks, GB, Mueller-Nurasyid, M, Noethen, MM, Paternoster, L, Pennell, Craig E., Pairo-Castineira, Erola, Peters, A, Rawlik, K, Robertson, CF, Rodriguez, E, Sebert, S, Simpson, A, Sleiman, PMA, Standl, M, Stoelzl, D, Strauch, K, Rüschendorf, Franz, Szwajda, A, Tenesa, A, Thompson, PJ, Ullemar, V, Visconti, A, Vonk, JM, Wang, CA, Weidinger, S, Wielscher, M, Worth, CL, Ahluwalia, Tarunveer S., Xu, C-J, Lee, Y-A, Almqvist, Catarina, Arnold, Andreas, Baurecht, Hansjörg

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

- Baxter, Paul S., Bell, Karen F. S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.

Paracingulate sulcus morphology is associated with hallucinations in the human brain

- Garrison, Jane R., Fernyhough, Charles, Catts, Stanley, Henskens, Frans, Pantelis, Christos, Loughland, Carmel, Simons, Jon S., McCarthy-Jones, Simon, Haggard, Mark, Carr, Vaughan, Schall, Ulrich, Scott, Rodney, Jablensky, Assen, Mowry, Bryan, Michie, Patricia

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

- Davies, Gail, Lam, Max, Liewald, David C. M., Knopman, DS, Kochan, NA, Konte, B, Kwok, JB, Le Hellard, S, Lee, T, Lehtimaki, T, Li, S-C, Liu, T, Koini, M, Okely, Judith A., London, E, Longstreth, WT, Lopez, OL, Loukola, A, Luck, T, Lundervold, AJ, Lundquist, A, Lyytikainen, L-P, Martin, NG, Montgomery, GW, Ahola-Olli, Ari V., Murray, AD, Need, AC, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, RA, Psaty, BM, Barnes, Catriona L. K., Reppermund, S, Riedel-Heller, SG, Rose, RJ, Rotter, JI, Roussos, P, Rovio, SP, Saba, Y., Sabb, FW, Sachdev, PS, Satizabal, CL, Bertram, Lars, Schmid, M, Scott, Rodney J., Scult, MA, Simino, J, Slagboom, PE, Smyrnis, N, Soumare, A, Stefanis, NC, Stott, DJ, Straub, RE, Bis, Joshua C., Sundet, K, Taylor, AM, Taylor, KD, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, AN, Kaprio, J, Wagner, M, Burdick, Katherine E., Wagner, H, Weinhold, L, Wen, KH, Widen, E, Yang, Q, Zhao, W, Adams, HHH, Arking, DE, Bilder, RM, Bitsios, P, Christoforou, Andrea, Boerwinkle, E, Chiba-Falek, O, Corvin, A, De Jager, PL, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, AL, Gill, M, Glahn, DC, DeRosse, Pamela, Hagg, S, Hansell, NK, Hariri, AR, Ikram, MK, Jukema, JW, Vuoksimaa, E, Keller, MC, Kremen, WS, Launer, L, Lindenberger, U, Djurovic, Srdjan, Palotie, A, Pedersen, NL, Pendleton, N, Porteous, DJ, Raikkonen, K, Raitakari, OT, Ramirez, A, Reinvang, I, Rudan, I, Rujescu, D, Harris, Sarah E., Espeseth, Thomas, Schmidt, R, Schmidt, H, Schofield, PW, Schofield, PR, Starr, JM, Steen, VM, Trollor, JN, Turner, ST, Van Duijn, CM, Villringer, A, Giakoumaki, Stella, Weinberger, DR, Weir, DR, Wilson, JF, Malhotra, A, McIntosh, AM, Gale, CR, Seshadri, S, Mosley, TH, Bressler, J, Lencz, T, Giddaluru, S, Deary, IJ, Gustavson, DE, Hayward, C, Hofer, E, Ikram, MA, Karlsson, R, Knowles, E, Lahti, J, Trampush, Joey W., Leber, M, Li, S, Mather, KA, Melle, I, Morris, D, Oldmeadow, Christopher, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Luciano, Michelle, Reynolds, CA, Sargurupremraj, M, Scholz, M, Smith, JA, Smith, AV, Terzikhan, N, Thalamuthu, A, Trompet, S, van der Lee, SJ, Ware, EB, Hill, W. David, Windham, BG, Wright, MJ, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, OA, Armstrong, NJ, Assareh, AA, Hagenaars, Saskia P., Attia, John R., Attix, D, Avramopoulos, D, Bennett, DA, Boehmer, AC, Boyle, PA, Brodaty, H, Campbell, H, Cannon, TD, Cirulli, ET, Ritchie, Stuart J., Congdon, E, Conley, ED, Corley, J, Cox, SR, Dale, AM, Dehghan, A, Dick, D, Dickinson, D, Eriksson, JG, Evangelou, E, Marioni, Riccardo E., Faul, JD, Ford, I, Freimer, NA, Gao, H, Giegling, I, Gillespie, NA, Gordon, SD, Gottesman, RF, Griswold, ME, Gudnason, V, Fawns-Ritchie, Chloe, Harris, TB, Hartmann, AM, Hatzimanolis, A, Heiss, G, Holliday, Elizabeth G., Joshi, PK, Kahonen, M, Kardia, SLR, Karlsson, I, Kleineidam, L

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

- Teng, Liu, Feng, Yu Chen, Guo, Su Tang, Wang, Pei Lin, Qi, Teng Fei, Yue, Yi Meng, Wang, Shi Xing, Zhang, Sheng Nan, Tang, Cai Xia, La, Ting, Zhang, Yuan Yuan, Zhao, Xiao Hong, Gao, Jin Nan, Wei, Li Yuan, Zhang, Didi, Wang, Jenny Y., Shi, Yujie, Liu, Xiao Ying, Li, Jin Ming, Cao, Huixia, Thorne, Rick F., Jin, Lei, Zhang, Xu Dong

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

- Maxwell, Michael J., Thekkedam, Chris, Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B., Mobli, Mehdi, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R.

Associations of autozygosity with a broad range of human phenotypes

- Clark, David W., Cocca, M, Collins, FS, Concas, MP, Corley, J, Cugliari, G, Van Dam, RM, Damulina, A, Daneshpour, MS, Day, FR, Delgado, GE, Dhana, K, Doney, ASF, Doerr, M, Doumatey, AP, Dzimiri, N, Ebenesersdottir, SS, Elliott, J, Elliott, P, Ewert, R, Felix, JF, Fischer, K, Freedman, BI, Girotto, G, Goel, A, Gogele, M, Goodarzi, MO, Graff, M, Granot-Hershkovitz, E, Grodstein, F, Guarrera, S, Gudbjartsson, DF, Guity, K, Gunnarsson, B, Guo, Y, Hagenaars, SP, Haiman, CA, Halevy, A, Harris, TB, Hedayati, M, van Heel, DA, Hirata, M, Hofer, I, Hsiung, CA, Huang, J, Hung, Y-J, Ikram, MA, Jagadeesan, A, Jousilahti, P, Kamatani, Y, Kanai, M, Kerrison, ND, Kessler, T, Khaw, K-T, Khor, CC, de Kleijn, DPV, Koh, W-P, Kolcic, I, Kraft, P, Kramer, BK, Kutalik, Z, Kuusisto, J, Langenberg, C, Launer, LJ, Lawlor, DA, Lee, I-T, Lee, W-J, Lerch, MM, Li, L, Liu, J, Loh, M, London, SJ, Loomis, S, Lu, Y, Luan, J, Magi, R, Manichaikul, AW, Manunta, P, Masson, G, Matoba, N, Mei, XW, Meisinger, C, Meitinger, T, Mezzavilla, M, Milani, L, Millwood, IY, Momozawa, Y, Moore, A, Morange, P-E, Moreno-Macias, H, Mori, TA, Morrison, AC, Muka, T, Murakami, Y, Murray, AD, de Mutsert, R, Mychaleckyj, JC, Nalls, MA, Nauck, M, Neville, MJ, Nolte, IM, Ong, KK, Orozco, L, Padmanabhan, S, Palsson, G, Pankow, JS, Pattaro, C, Pattie, A, Polasek, O, Poulter, N, Pramstaller, PP, Quintana-Murci, L, Raikkonen, K, Ralhan, S, Rao, DC, van Rheenen, W, Rich, SS, Ridker, PM, Rietveld, CA, Robino, A, van Rooij, FJA, Ruggiero, D, Saba, Y, Sabanayagam, C, Sabater-Lleal, M, Felicita Sala, C, Salomaa, V, Sandow, K, Schmidt, H, Scott, LJ, Scott, WR, Sedaghati-Khayat, B, Sennblad, B, van Setten, J, Sever, PJ, Sheu, WH-H, Shi, Y, Shrestha, S, Shukla, SR, Sigurdsson, JK, Sikka, TT, Singh, JR, Smith, BH, Stancakova, A, Stanton, A, Starr, JM, Stefansdottir, L, Straker, L, Sulem, P, Sveinbjornsson, G, Swertz, MA, Taylor, AM, Taylor, KD, Terzikhan, N, Tham, Y-C, Thorleifsson, G, Thorsteinsdottir, U, Tillander, A, Tracy, RP, Tusie-Luna, T, Tzoulaki, I, Vaccargiu, S, Vangipurapu, J, Veldink, JH, Vitart, V, Volker, U, Vuoksimaa, E, Wakil, SM, Waldenberger, M, Wander, GS, Wang, YX, Wareham, NJ, Wild, S, Yajnik, CS, Yuan, J-M, Zeng, L, Zhang, L, Zhou, J, Amin, N, Asselbergs, FW, Bakker, SJL, Becker, DM, Lehne, B, Bennett, DA, van den Berg, LH, Berndt, SI, Bharadwaj, D, Bielak, LF, Bochud, M, Boehnke, M, Bouchard, C, Bradfield, JP, Brody, JA, Campbell, A, Carmi, S, Caulfield, MJ, Cesarini, D, Chambers, JC, Chandak, GR, Cheng, C-Y, Ciullo, M, Cornelis, M, Cusi, D, Smith, GD, Deary, IJ, Dorajoo, R, van Duijn, CM, Ellinghaus, D, Erdmann, J, Eriksson, JG, Evangelou, E, Evans, MK, Faul, JD, Feenstra, B, Feitosa, M, Foisy, S, Franke, A, Friedlander, Y, Gasparini, P, Gieger, C, Gonzalez, C, Goyette, P, Grant, SFA, Griffiths, LR, Groop, L, Gudnason, V, Gyllensten, U, Hakonarson, H, Hamsten, A, van der Harst, P, Heng, C-K, Hicks, AA, Hochner, H, Huikuri, H, Hunt, SC, Jaddoe, VWV, De Jager, PL, Johannesson, M, Johansson, A, Jonas, JB, Jukema, JW, Junttila, J, Kaprio, J, Kardia, SLR, Karpe, F, Kumari, M, Laakso, M, van der Laan, SW, Lahti, J, Laudes, M, Lea, RA, Lieb, W, Lumley, T, Martin, NG, Marz, W, Matullo, G, McCarthy, MI, Medland, SE, Merriman, TR, Metspalu, A, Meyer, BF, Mohlke, KL, Montgomery, GW, Mook-Kanamori, D, Munroe, PB, North, KE, Nyholt, DR, O'connell, JR, Ober, C, Oldehinkel, AJ, Palmas, W, Palmer, C, Pasterkamp, GG, Patin, E, Pennell, CE, Perusse, L, Peyser, PA, Pirastu, M, Polderman, TJC, Porteous, DJ, Posthuma, D, Psaty, BM, Rioux, JD, Rivadeneira, F, Rotimi, C, Rotter, JI, Rudan, I, Den Ruijter, HM, Sanghera, DK, Sattar, N, Schmidt, R, Schulze, MB, Schunkert, H, Scott, RA, Shuldiner, AR, Sim, X, Small, N, Smith, JA, Sotoodehnia, N, Tai, E-S, Teumer, A, Timpson, NJ, Toniolo, D, Tregouet, D-A, Tuomi, T, Vollenweider, P, Wang, CA, Weir, DR, Whitfield, JB, Wijmenga, C, Wong, T-Y, Wright, J, Yang, J, Yu, L, Zemel, BS, Zonderman, AB, Perola, M, Magnusson, PKE, Uitterlinden, AG, Kooner, JS, Chasman, DI, Loos, RJF, Franceschini, N, Franke, L, Haley, CS, Hayward, C, Walters, RG, Perry, JRB, Esko, T, Helgason, A, Stefansson, K, Joshi, PK, Kubo, M, Wilson, JF, Okada, Yukinori, Deelen, Patrick, Wang, Carol A., Pennell, Craig E., Orozco, Lorena, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M., Moore, Kristjan H. S., Baumbach, Clemens, Biino, G, Bixley, MJ, Brumat, M, Chai, J-F, Corre, T, Cousminer, DL, Dekker, AM, Eccles, DA, Van Eijk, KR, Mason, Dan, Fuchsberger, C, Gao, H, Germain, M, Gordon, SD, de Haan, HG, Harris, SE, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, IE, Pirastu, Nicola, Jia, Y, Kacprowski, T, Karlsson, T, Kleber, ME, Li, SA, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Gandin, Ilaria, Montasser, ME, van der Most, PJ, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, RB, Priyanka, TDS, Rizzi, F, Salvi, E, Mattsson, Hannele, Sapkota, BR, Shriner, D, Skotte, L, Smart, MC, Smith, AV, van der Spek, A, Spracklen, CN, Strawbridge, RJ, Tajuddin, SM, Trompet, S, Barnes, Catriona L. K., Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, HR, Wootton, RE, Yanek, LR, Yao, J, Yousri, NA, Zhao, W, Lin, Kuang, Adeyemo, AA, Afaq, S, Alberto Aguilar-Salinas, C, Akiyama, M, Albert, ML, Allison, MA, Alver, M, Aung, T, Azizi, F, Bentley, AR, Zhao, Jing Hua, Boeing, H, Boerwinkle, E, Borja, JB, de Borst, GJ, Bottinger, EP, Broer, L, Campbell, H, Chanock, S, Chee, M-L, Chen, G

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

- Joubert, Bonnie R., den Dekker, Herman T., Håberg, Siri E., Reese, Sarah E., Peters, Marjolein J., Kulle Andreassen, Bettina, Steegers, Eric A. P., Nilsen, Roy M., Vollset, Stein E., Midttun, Øivind, Ueland, Per M., Franco, Oscar H., Felix, Janine F., Dehghan, Abbas, de Jongste, Johan C., Wu, Michael C., Wang, Tianyuan, Peddada, Shyamal D., Jaddoe, Vincent W. V., Nystad, Wenche, Duijts, Liesbeth, London, Stephanie J., Bohlin, Jon, Ligthart, Symen, Beckett, Emma, Tiemeier, Henning, van Meurs, Joyce B., Uitterlinden, Andre G., Hofman, Albert

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

- To, Eunice E., Vlahos, Ross, Starkey, Malcolm R., van der Sluis, Renee, Lewin, Sharon R., Bozinovski, Steven, O'Neill, Luke A. J., Quach, Tim, Porter, Christopher J. H., Brooks, Doug A., O'Leary, John J., Selemidis, Stavros, Luong, Raymond, Halls, Michelle L., Reading, Patrick C., King, Paul T., Chan, Christopher, Drummond, Grant R., Sobey, Christopher G., Broughton, Brad R. S.

Ion currents through Kir potassium channels are gated by anionic lipids

- Jin, Ruitao, He, Sitong, Black, Katrina A., Clarke, Oliver B., Wu, Di, Bolla, Jani R., Johnson, Paul, Periasamy, Agalya, Wardak, Ahmad, Czabotar, Peter, Colman, Peter M., Robinson, Carol V., Laver, Derek, Smith, Brian J., Gulbis, Jacqueline M.

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

- Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M., Curtis, David J.

A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.

- Hungate, Eric A., Vora, Sapana R., Rudant, Jéremie, Orsi, Laurent, Clavel, Jacqueline, Milne, Elizabeth, Scott, Rodney J., Pui, Ching-Hon, Cox, Nancy J., Loh, Mignon L., Yang, Jun J., Skol, Andrew D., Gamazon, Eric R., Onel, Kenan, Moriyama, Takaya, Best, Timothy, Hulur, Imge, Lee, Younghee, Evans, Tiffany-Jane, Ellinghaus, Eva, Stanulla, Martin

Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

- Ibn Sina, Abu Ali, Carrascosa, Laura G., Korbie, Darren, Trau, Matt, Liang, Ziyu, Grewal, Yadveer S., Wardiana, Andri, Shiddiky, Muhammad J. A., Gardiner, Robert A., Samaratunga, Hemamali, Gandhi, Maher K., Scott, Rodney J.

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

- Pinese, Mark, Lacaze, Paul, Cristina, Tina Navin, Kahl, Vivian F. S., Statham, Aaron L., Woods, Robyn L., McNeil, John J., Riaz, Moeen, Barr, Margo, Nelson, Mark R., Reid, Christopher M., Murray, Anne M., Rath, Emma M., Shah, Raj C., Wolfe, Rory, Atkins, Joshua R., Fitzsimmons, Chantel, Cairns, Heath M., Green, MJ, Carr, VJ, Cowley, MJ, Pickett, HA, James, PA, Stone, Andrew, Powell, JE, Kaplan, W, Gibson, G, Gyllensten, U, Cairns, Murray J., McNamara, M, Dinger, ME, Thomas, DM, Brion, Marie-Jo, Ameur, Adam, Nagpal, Sini, Puttick, Clare, Husson, Shane, Degrave, Dmitry

Potential increase in coastal wetland vulnerability to sea-level rise suggested by considering hydrodynamic attenuation effects

- Rodriguez, José F., Saco, Patricia M., Sandi, Steven, Saintilan, Neil, Riccardi, Gerardo

Organic coating on biochar explains its nutrient retention and stimulation of soil fertility

- Hagemann, Nikolas, Joseph, Stephen, McKenna, Amy, Albu, Mihaela, Mayrhofer, Claudia, Obst, Martin, Conte, Pellegrino, Dieguez-Alonso, Alba, Orsetti, Silvia, Subdiaga, Edisson, Behrens, Sebastian, Kappler, Andreas, Schmidt, Hans-Peter, Kammann, Claudia I., Harter, Johannes, Borch, Thomas, Young, Robert B., Varga, Krisztina, Taherymoosavi, Sarasadat, Elliott, K. Wade

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women

- Parkington, Helena C., Stevenson, Janet, Tonta, Mary A., Paul, Jonathan, Butler, Trent, Maiti, Kaushik, Chan, Eng-Cheng, Sheehan, Penelope M., Brennecke, Shaun P., Coleman, Harold A., Smith, Roger

Mechanisms underlying pathological cortical bursts during metabolic depletion

- Dutta, Shrey, Iyer, Kartik K., Vanhatalo, Sampsa, Breakspear, Michael, Roberts, James A.

Direct observation of intrinsic room-temperature ferroelectricity in 2D layered CuCrP₂S₆

- Io, Weng Fu, Pang, Sin-Yi, Yi, Jiabao, Hao, Jianhua, Wong, Lok Wing, Zhao, Yuqian, Ding, Ran, Mao, Jianfeng, Zhao, Yifei, Guo, Feng, Yuan, Shuoguo, Zhao, Jiong

TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease

- Van Haute, Lindsey, O’Connor, Emily, Bonneau, Dominique, Brunetti-Pierri, Nicola, Cappuccio, Gerarda, Caruana, NikeishaJ, Dominik, Natalia, Goel, Himanshu, Helman, Guy, Houlden, Henry, Lenaers, Guy, Mention, Karine, Díaz-Maldonado, Hector, Murphy, D, Nandeesh, B, Olimpio, C, Powell, CA, Preethish-Kumar, V, Procaccio, V, Rius, R, Rebelo-Guiomar, P, Simons, C, Vengalil, S, Munro, Benjamin, Zaki, MS, Ziegler, A, Thorburn, DR, Stroud, DA, Maroofian, R, Christodoulou, J, Gustafsson, C, Nalini, A, Lochmüller, H, Minczuk, M, Polavarapu, Kiran, Horvath, R, Hock, Daniella H., Arunachal, Gautham, Athanasiou-Fragkouli, Alkyoni, Bardhan, Mainak, Barth, Magalie