A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

- Sutton, Selina K., Carter, Daniel R., McArthur, Grant A., Cheung, Belamy B., Marshall, Glenn M., Kim, Patrick, Tan, Owen, Arndt, Greg M., Zhang, Xu Dong, Baell, Jonathan, Noll, Benjamin D., Wang, Shudong, Kumar, Naresh

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

- Smith, Amanda M., Dun, Matthew D., Toop, Hamish, Lock, Richard B., Powell, Jason A., Thomas, Daniel, Guthridge, Mark A., Moore, Andrew, Ashman, Leonie K., Skelding, Kathryn A., Enjeti, Anoop, Verrills, Nicole M., Lee, Erwin M., Harrison, Celeste, Kahl, Richard, Flanagan, Hayley, Panicker, Nikita, Mashkani, Baratali, Don, Anthony S., Morris, Jonathan

Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium

- Bajwa, Preety, Nagendra, Prathima B., Nielsen, Sarah, Sahoo, Subhransu S., Bielanowicz, Amanda, Lombard, Janine M., Wilkinson, J. Erby, Miller, Richard A., Tanwar, Pradeep S.

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma

- Liu, Fen, Jiang, Chen Chen, Thorne, Rick F., Jin, Lei, Wang, Qi, Zhang, Xu Dong, Yan, Xu Guang, Tseng, Hsin-Yi, Wang, Chun Yan, Zhang, Yuan Yuan, Yari, Hamed, La, Ting, Farrelly, Margaret, Guo, Su Tang

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma

- Liu, Fen, Jiang, Chen Chen, Thorne, Rick F., Jin, Lei, Wang, Qi, Zhang, Xu Dong, Yan, Xu Guang, Tseng, Hsin-Yi, Wang, Chun Yan, Zhang, Yuan Yuan, Yari, Hamed, La, Ting, Farrelly, Margaret, Guo, Su Tang

C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning

- Kalm, Marie, Andreasson, Ulf, Björk-Eriksson, Thomas, Zetterberg, Henrik, Pekny, Milos, Blennow, Kaj, Pekna, Marcela, Blomgren, Klas

Chemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme

- Yu, Xiaohui, Yang, Lifang, Cairns, Murray J., Dass, Crispin, Saravolac, Edward, Li, Xiong, Sun, Lun-Quan

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

- Moran-Jones, Kim, Gloss, Brian S., Spong, Suzanne M., Scarlett, Christopher J., Hacker, Neville F., Ghosh, Sue, Mok, Samuel C., Birrer, Michael J., Samimi, Goli, Murali, Rajmohan, Chang, David K., Colvin, Emily K., Jones, Marc D., Yuen, Samuel, Howell, Viive M., Brown, Laura M., Wong, Carol W.

Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs

- Kumar, Manish, Atkins, Joshua, Cairns, Murray, Ali, Ayesha, Tanwar, Pradeep S.

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

- Shahbazi, Jeyran, Scarlett, Christopher J., Lock, Richard B., Liu, Tao, Norris, Murray D., Liu, Bing, Haber, Michelle, Tee, Andrew E., Carrier, Alice, Biankin, Aandrew V., London, Wendy B., Marshall, Glenn M.

Identification of the microRNA networks contributing to macrophage differentiation and function

- Zhou, Hong, Zhang, Jie, Eyers, Fiona, Xiang, Yang, Herbert, Cristan, Tay, Hock L., Foster, Paul S., Yang, Ming

Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis

- Sahoo, Subhransu S., Quah, Min Yuan, Nielsen, Sarah, Atkins, Joshua, Au, Gough G., Cairns, Murray J., Nahar, Pravin, Lombard, Janine M., Tanwar, Pradeep S.

INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas

- Chi, Meng Na, Guo, Su Tang, Croft, Amanda, Hondermarck, Hubert, Scolyer, Richard A., Jiang, Chen Chen, Zhang, Xu Dong, Wilmott, James S., Guo, Xiang Yun, Yan, Xu Guang, Wang, Chun Yan, Liu, Xiao Ying, Jin, Lei, Tseng, Hsin-Yi, Liu, Tao

miR-518f-5p decreases tetraspanin CD9 protein levels and differentially affects non-tumourigenic prostate and prostate cancer cell migration and adhesion

- Bond, Danielle R., Naudin, Crystal, Carroll, Adam P., Goldie, Belinda J., Brzozowski, Joshua S., Jankowski, Helen M., Cairns, Murray J., Ashman, Leonie K., Scarlett, Christopher J., Weidenhofer, Judith

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells

- Liu, Yi Lun, Lai, Fritz, Jin, Lei, Zhang, Xu Dong, Wilmott, James S., Yan, Xu Guang, Liu, Xiao Ying, Luan, Qi, Guo, Su Tang, Jiang, Chen Chen, Tseng, Hsin-Yi, Scolyer, Richard A.

Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions

- Nagendra, Prathima B., Goad, Jyoti, Nielsen, Sarah, Rassam, Loui, Lombard, Janine M., Nahar, Pravin, Tanwar, Pradeep S.

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

- Bajwa, Preety, Nielsen, Sarah, Lombard, Janine M., Rassam, Loui, Nahar, Pravin, Rueda, Bo R., Wilkinson, J. Erby, Miller, Richard A., Tanwar, Pradeep S.

ProNGF is a potential diagnostic biomarker for thyroid cancer

- Faulkner, Sam, Roselli, Severine, Demont, Yohann, Pundavela, Jay, Choquet, Genevieve, Leissner, Philippe, Oldmeadow, Christopher, Attia, John, Walker, Marjorie M., Hondermarck, Hubert

Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922

- Wang, Chun Yan, Guo, Su Tang, Jin, Lei, Zhang, Xu Dong, Jiang, Chen Chen, Wang, Jia Yu, Yan, Xu Guang, Farrelly, Margaret, Zhang, Yuan Yuan, Liu, Fen, Yari, Hamed, La, Ting, Lei, Fu Xi

Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair

- Budden, Timothy, Davey, Ryan J., Vilain, Ricardo E., Ashton, Katie A., Braye, Stephen G., Beveridge, Natalie J., Bowden, Nikola A.