Advances in Respiratory Physiology in Mouse Models of Experimental Asthma

- Carroll, Olivia R., Pillar, Amber L., Brown, Alexandra C., Feng, Min, Chen, Hui, Donovan, Chantal

Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion

- Donovan, Chantal, Kim, Richard Y, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R., Nguyen, Duc H., Budden, Kurtis F., Kumar, Vinod, Galvao, Izabela, Wark, Peter A. B., Horvat, Jay C., Hansbro, Philip M., Ab Wark, P, Oliver, BG, Horvat, JC, Hansbro, PM, Jarnicki, Andrew G., Brown, Alexandra C., Jones-Freeman, Bernadette, Gomez, Henry M., Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith

Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma

- Tu, Xiaofan, Gomez, Henry M., Donovan, Chantal, Kim, Richard Y., Brown, Alexandra C., de Jong, Emma, Galvao, Izabela, Faiz, Alen, Bosco, Anthony, Horvat, Jay C., Hansbro, Philip

Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap

- Tu, Xiaofan, Kim, Richard Y., Loering, Svenja, Nguyen, Duc H., Nair, Prema Mono, Haw, Tatt Jhong, Alemao, Charlotte A., Faiz, Alen, Tay, Hock L., Wark, Peter A. B., Knight, Darryl A., Foster, Paul S., Brown, Alexandra C., Bosco, Anthony, Horvat, Jay C., Hansbro, Philip M., Donovan, Chantal, de Jong, Emma, Jones-Freeman, Bernadette, Ali, Md Khadem, Gomez, Henry M., Budden, Kurtis F., Starkey, Malcolm R., Cameron, Guy J. M.

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

- Liu, Gang, Cooley, Marion A., Tay, Hock, Foster, Paul S., Wark, Peter A., Horvat, Jay C., Bourke, Jane E., Grainge, Chris L., Argraves, W. Scott, Oliver, Brian G., Knight, Darryl A., Burgess, Janette K., Nair, Prema M., Hansbro, Philip M., Donovan, Chantal, Hsu, Alan C., Jarnicki, Andrew G., Haw, Tatt Jhong, Hansbro, Nicole G., Ge, Qi, Brown, Alexandra C.

Characterization and inhibition of inflammasome responses in severe and non-severe asthma

- Horvat, Jay C., Kim, Richard Y., Weaver, Natasha, Augood, Christopher, Brown, Alexandra C., Donovan, Chantal, Dupre, Pierrick, Gunawardhana, Lakshitha, Mayall, Jemma R., Hansbro, Nicole G., Robertson, Avril A. B., O'Neill, Luke A. J., Cooper, Matthew A., Holliday, Elizabeth G., Hansbro, Philip M., Gibson, Peter G.

COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species

- Simpson, Jodie L., Baines, Katherine J., Horvat, Jay C., Essilfie, Ama-Tawiah, Brown, Alexandra C., Tooze, Melinda, McDonald, Vanessa M., Gibson, Peter G., Hansbro, Philip M.

Critical role for iron accumulation in the pathogenesis of fibrotic lung disease

- Ali, Md Khadem, Kim, Richard Y., Borghuis, Theo, Karim, Rafia, Pinkerton, James W., Aryal, Ritambhara, Heidari, Moones, Martin, Kristy L., Burgess, Janette K., Oliver, Brian G., Trinder, Debbie, Johnstone, Daniel M., Brown, Alexandra C., Milward, Elizabeth A., Hansbro, Philip M., Horvat, Jay C., Donovan, Chantal, Vanka, Kanth S., Mayall, Jemma R., Liu, Gang, Pillar, Amber L., Jones-Freeman, Bernadette, Xenaki, Dikaia

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

- Ali, Md Khadem, Kim, Richard Y., Donovan, Chantal, Pathinayake, Prabuddha S., Carroll, Olivia R., Trinder, Debbie, Tay, Hock L., Badi, Yusef E., Kermani, Nazanin Z., Guo, Yi-Ke, Aryal, Ritambhara, Mumby, Sharon, Brown, Alexandra C., Pavlidis, Stelios, Adcock, IM, Weaver, Jessica, Xenaki, D, Oliver, BG, Holliday, Elizabeth G., Foster, Peter S., Wark, Peter A., Johnstone, DM, Milward, EA, Mayall, Jemma R., Hansbro, Philip M., Horvat, Jay C., Karim, Rafia, Pinkerton, James W., Liu, Gang, Martin, Kristy L., Starkey, Malcolm R., Pillar, Amber L.

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis

- Scott, Hayley A., Ng, Shawn H. M., McLoughlin, Rebecca F., Valkenborghs, Sarah R., Nair, Parameswaran, Brown, Alexandra C., Carroll, Olivia R., Horvat, Jay C., Wood, Lisa G.

Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma

- Pathinayake, Prabuddha S., Waters, David W., Gibson, Peter G., Hansbro, Philip M., Wark, Peter A. B., Nichol, Kristy S., Brown, Alexandra C., Reid, Andrew T., Hsu, Alan Chen-Yu, Horvat, Jay C., Wood, Lisa G., Baines, Katherine J., Simpson, Jodie L.

Generation of cardio-protective antibodies after pneumococcal polysaccharide vaccine: Early results from a randomised controlled trial

- Ren, Shu, Hansbro, Philip M., Srikusalanukul, Wichat, Horvat, Jay C., Hunter, Tegan, Brown, Alexandra C., Peel, Roseanne, Faulkner, Jack, Evans, Tiffany-Jane, Li, Shu Chuen, Newby, David, Hure, Alexis, Abhayaratna, Walter P., Tsimikas, Sotirios, Gonen, Ayelet, Witztum, Joseph L., Attia, John

Glycemic variability in diabetes increases the severity of influenza

- Marshall, Rebecca J., Armart, Pornthida, Gallo, Linda A., Short, Kirsty R., Hulme, Katina D., Chew, Keng Ylh, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle

Human beta-defensin-2 suppresses key features of asthma in murine models of allergic airways disease

- Pinkerton, James W., Kim, Richard Y., Nordkild, Peter, Horvat, Jay C., Jensen, Benjanim A. H., Wehkamp, Jan, Hansbro, Philip M., Koeninger, Louis, Armbruster, Nicole S., Hansbro, Nicole G., Brown, Alexandra C., Jayaraman, Ranjith, Shen, Sijie, Malek, Nisar, Cooper, Matthew A.

Interferon-epsilon is a novel regulator of NK cell responses in the uterus

- Mayall, Jemma R., Horvat, Jay C., de Geus, Eveline D., Starkey, Malcolm R., Kim, Richard Y., Daly, Katie, Goggins, Bridie J., Keely, Simon, Maltby, Steven, Baldwin, Rennay, Foster, Paul S., Boyle, Michael J., Mangan, Niamh E., Tanwar, Pradeep S., Huntington, ND, Hertzog, PJ, Hansbro, Philip M., Chevalier, Anne, McCarthy, Huw, Hampsey, Daniel, Donovan, Chantal, Brown, Alexandra C., Matthews, Antony Y., de Weerd, Nicole A.

Investigating the links between lower iron status in pregnancy and respiratory disease in offspring using murine models

- Gomez, Henry M., Pillar, Amber L., Brown, Alexandra C., Kim, Richard Y., Ali, Md Khadem, Essilfie, Ama-Tawiah, Vanders, Rebecca, Frazer, David M., Anderson, Gregory J., Hansbro, Philip M., Collison, Adam M., Jensen, Megan E., Murphy, Vanessa E., Johnstone, Daniel M., Reid, David, Milward, Elizabeth A., Donovan, Chantal, Horvat, Jay C.

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

- Runtsch, Marah C., Angiari, Stefano, Mendez, Rui Santalla, Zotta, Alessia, Peace, Christian G., Walsh, Aoife, Chirillo, Roberta, Hams, Emily, Fallon, Padraic G., Jayamaran, Ranjith, Dua, Kamal, Brown, Alexandra C., Hooftman, Alexander, Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Wang, C, O'Neill, LAJ, Wadhwa, Ridhima, Zhang, Yanling, Zheng, Yunan, Spina, Joseph S., Ruzek, Melanie C., Argiriadi, Maria A., McGettrick, Anne F.

PD-L1 promotes early-life chlamydia respiratory infection-induced severe allergic airway disease

- Starkey, Malcolm R., Nguyen, Duc H., Brown, Alexandra C., Essilfie, Ama-Tawiah, Kim, Richard Y., Yagita, Hideo, Horvat, Jay C., Hansbro, Philip M.

Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen

- Thorburn, Alison N., Brown, Alexandra C., Nair, Prema M., Chevalier, Nina, Foster, Paul S., Gibson, Peter G., Hansbro, Philip M.

Polycomb repressive complex 2 is a critical mediator of allergic inflammation

- Keenan, Christine R., Iannarella, Nadia, Garnham, Alexandra L., Brown, Alexandra C., Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Nutt, Stephen L., Allan, Rhys S.