Leukemia inhibitory factor-receptor is dispensable for prenatal testis development but is required in sertoli cells for normal spermatogenesis in mice
- Creator: Curley, Michael , Milne, Laura , Smith, Sarah , Atanassova, Nina , Rebourcet, Diane , Darbey, Annalucia , Hadoke, Patrick W. F. , Wells, Sara , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
Human Adipose-derived pericytes display steroidogenic lineage potential in vitro and influence Leydig cell regeneration in vivo in rats
- Creator: Curley, Michael , Gonzalez, Zaniah N. , Milne, Laura , Hadoke, Patrick , Handel, Ian , Péault, Bruno , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging
- Creator: Curley, Michael , Milne, Laura , Smith, Sarah , Jørgensen, Anne , Frederiksen, Hanne , Hadoke, Patrick , Potter, Paul , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
Leukemia inhibitory factor-receptor signalling negatively regulates gonadotrophin-stimulated testosterone production in mouse Leydig Cells: LIFR Signalling in Leydig Cells
- Creator: Curley, Michael , Darbey, Annalucia , O'Donnell, Liza , Kilcoyne, Karen R. , Wilson, Kirsten , Mungall, Will , Rebourcet, Diane , Guo, Jingtao , Mitchell, Rod T. , Smith, Lee B.
- Resource Type: journal article
- Date: 2022
A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice
- Creator: Darbey, Annalcuia , Rebourcet, Diane , Curley, Michael , Kilcoyne, Karen , Jeffery, Nathan , Reed, Natalie , Milne, Laura , Roesl, Cornelia , Brown, Pamela , Smith, Lee B.
- Resource Type: journal article
- Date: 2020
Deliverable transgenics & gene therapy possibilities for the testes
- Creator: Darbey, Annalucia , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity
- Creator: Gannon, Anne-Louise , O'Hara, Laura , Mason, Ian J. , Jørgensen, Anne , Frederiksen, Hanne , Curley, Michael , Milne, Laura , Smith, Sarah , Mitchell, Rod T. , Smith, Lee B.
- Resource Type: journal article
- Date: 2021
Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing
- Creator: Gannon, Anne-Louise , O'Hara, Laura , Mason, J. Ian , Jørgensen, Anne , Frederiksen, Hanne , Milne, Laura , Smith, Sarah , Mitchell, Rod T. , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders
- Creator: Gannon, Anne-Louise , O'Hara, Laura , Mitchell, Rod T. , Smith, Lee B. , Mason, J. Ian , Rebourcet, Diane , Smith, Sarah , Traveres, Adriana , Alcaide-Corral, Carlos Jose , Frederiksen, Hanne , Jorgensen, Anne , Milne, Laura
- Resource Type: journal article
- Date: 2019
A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function
- Creator: Gannon, Anne-Louise , Darbey, Annalucia L. , Rebourcet, Diane , Chensee, Grace , Lawrence, Ben M. , O'Donnell, Liza , Kelso, Joanna , Reed, Natalie , Parameswaran, Shanmathi , Smith, Sarah , Smith, Lee B.
- Resource Type: journal article
- Date: 2022
Xenotransplantation as a model for human testicular development
- Creator: Hutka, Marsida , Smith, Lee B. , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2017
Exogenous gonadotrophin stimulation induces partial maturation of human sertoli cells in a testicular xenotransplantation model for fertility preservation
- Creator: Hutka, Marsida , Smith, Lee B. , Goossens, Ellen , Wallace, W. Hamish B. , Stukenborg, Jan-Bernd , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2020
Fertility preservation in childhood cancer: endocrine activity in prepubertal human testis xenografts exposed to a pubertal hormone environment
- Creator: Hutka, Marsida , Kadam, Prashant , Van Saen, Dorien , Homer, Natalie Z. M. , Onofre, Jaime , Wallace, W. Hamish B. , Smith, Lee B. , Stukenborg, Jan-Bernd , Goossens, Ellen , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2020
Bi-allelic recessive loss-of-function variants in FANCM cause non-obstructive azoospermia
- Creator: Kasak, Laura , Punab, Margus , Smith, Lee B. , Conrad, Donald F. , Laan, Maris , Nagirnaja, Liina , Grigorova, Marina , Minajeva, Ave , Lopes, Alexandra M. , Punab, Anna Maria , Aston, Kenneth I. , Carvalho, Filipa , Laasik, Eve
- Resource Type: journal article
- Date: 2018
New Insights into Testosterone Biosynthesis: Novel Observations from HSD17B3 Deficient Mice
- Creator: Lawrence, Ben M. , O'Donnell, Liza , Smith, Lee B. , Rebourcet, Diane
- Resource Type: journal article
- Date: 2022
A graphical and computational modeling platform for biological pathways
- Creator: Livigni, Alessandra , O'Hara, Laura , Polak, Marta E. , Angus, Tim , Wright, Derek W. , Smith, Lee B. , Freeman, Tom C.
- Resource Type: journal article
- Date: 2018
DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads
- Creator: Macdonald, Joni , Kilcoyne, Karen R. , Sharpe, Richard M. , Kavanagh, Áine , Anderson, Richard A. , Brown, Pamela , Smith, Lee B. , Jørgensen, Anne , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2018
Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells
- Creator: Neirijnck, Yasmine , Calvel, Pierre , Smith, Lee B. , Nef, Serge , Kilcoyne, Karen R. , Kühne, Françoise , Stévant, Isbelle , Griffeth, Richard J. , Pitetti, Jean-Lüc , Andric, Silvana A. , Hu, Meng-Chun , Pralong, François
- Resource Type: journal article
- Date: 2018
Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid
- Creator: O'Donnell, Liza , Dagley, Laura F. , Curley, Michael , Darbey, Annalucia , O'Shaughnessy, Peter J. , Diemer, Thorsten , Pilatz, Adrian , Fietz, Daniela , Stanton, Peter G. , Smith, Lee B. , Rebourcet, Diane
- Resource Type: journal article
- Date: 2023
Sperm-specific proteins: new implications for diagnostic development and cancer immunotherapy
- Creator: O'Donnell, Liza , Smith, Lee B. , Rebourcet, Diane
- Resource Type: journal article
- Date: 2022