Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract
- Creator: Tan, Ava Grace , Kifley, Annette , Cheng, Ching-Yu , Mitchell, Paul , Wang, Jie Jin , Holliday, Elizabeth G. , Klein, Barbara E. , Iyengar, Sudha K. , Lee, Kristine E. , Jun, Gyungah R. , Cumming, Robert G. , Zhao, Wanting , Wong, Tien Yin
- Resource Type: journal article
- Date: 2018
Associations between methylenetetrahydrofolate reductase polymorphisms, serum homocysteine levels, and incident cortical cataract
- Creator: Tan, Ava Grace , Kifley, Annette , Klein, Barbara E. K. , Cheng, Ching-Yu , Iyengar, Sudha K. , Wang, Jie Jin , Mitchell, Paul , Rochtchina, Elena , Flood, Victoria M. , Cumming, Robert G. , Jun, Gyungah , Holliday, Elizabeth G. , Scott, Rodney J. , Teo, Yik Ying
- Resource Type: journal article
- Date: 2016
Carbohydrate nutrition and development of adiposity during adolescence
- Creator: Gopinath, Bamini , Flood, Victoria M. , Rochtchina, Elena , Baur, Louise A. , Louie, Jimmy Chun Yu , Smith, Wayne , Mitchell, Paul
- Resource Type: journal article
- Date: 2013
Carbohydrate nutrition is associated with changes in the retinal vascular structure and branching pattern in children
- Creator: Gopinath, Bamini , Flood, Victori M. , Wang, Jie Jin , Smith, Wayne , Rochtchina, Elena , Louie, Jimmy C. Y. , Wong, Tien Y. , Brand-Miller, Jennie , Mitchell, Paul
- Resource Type: journal article
- Date: 2012
Cohort profile: the Dynamic Analyses to Optimize Ageing (DYNOPTA) Project
- Creator: Anstey, Kaarin J. , Byles, Julie E. , Windsor, Timothy D. , Ross, Lesley , Bartsch, Lauren , Burns, Richard A. , Kiely, Kim , Birrell, Carole L. , Broe, Gerald A. , Shaw, Jonathon , Kendig, Hal , Luszcz, Mary A. , Mitchell, Paul , Steel, David , Booth, Heather , Browning, Colette , Butterworth, Peter , Cumming, Robert G. , Healy, Judith
- Resource Type: journal article
- Date: 2010
Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort
- Creator: Wang, Jie Jin , Rochtchina, Elena , Smith, Wayne , Klein, Ronald , Klein, Barbara E. K. , Joshi, Tripti , Sivakumaran, Theru A. , Iyengar, Sudha , Mitchell, Paul
- Resource Type: journal article
- Date: 2009
Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study
- Creator: de Vries, Paul S. , Sabater-Lleal, Maria , Marioni, Riccardo E. , Steri, Maristella , Weng, Lu-Chen , Pool, Rene , Grossmann, Vera , Brody, Jennifer A. , Venturini, Cristina , Tanaka, Toshiko , Rose, Lynda M. , Oldmeadow, Christopher , Chasman, Daniel I. , Mazur, Johanna , Basu, Saonli , Frånberg, Mattias , Yang, Qiong , Ligthart, Symen , Hottenga, Jouke J. , Rumley, Ann , Mulas, Antonella , de Craen, Anton J. M. , Grotevendt, Anne , Trompet, Stella , Taylor, Kent D. , Delgado, Graciela E. , Kifley, Annette , Lopez, Lorna M. , Berentzen, Tina L. , Mangino, Massimo , Bandinelli, Stefania , Morrison, Alanna C. , Hamsten, Anders , Tofler, Geoffrey , Ahluwalia, Tarunveer S. , de Maat, Moniek P. M. , Draisma, Harmen H. M. , Lowe, Gordon D. , Zoledziewska, Magdalena , Sattar, Naveed , Lackner, Karl J. , Völker, Uwe , McKnight, Barbara , Huang, Jie , Holliday, Elizabeth G. , Teumer, Alexander , McEvoy, Mark A. , Starr, John M. , Hysi, Pirro G. , Hernandez, Dena G. , Guan, Weihua , Rivadeneira, Fernando , McArdle, Wendy L. , Slagboom, P. Eline , Zeller, Tanja , Psaty, Bruce M. , Kleber, Marcus E. , Uitterlinden, André G. , de Geus, Eco J. C. , Stott, David J. , Binder, Harald , Hofman, Albert , Franco, Oscar H. , Rotter, Jerome I. , Ferrucci, Luigi , Spector, Tim D. , Deary, Ian J. , Chen, Ming-Huei , März, Winfried , Greinacher, Andreas , Wild, Philipp S. , Cucca, Francesco , Boomsma, Dorret I. , Watkins, Hugh , Tang, Weihong , Ridker, Paul M. , Jukema, Jan W. , Scott, Rodney J. , Wang, Jie Jin , Mitchell, Paul , Hansen, Torben , O'Donnell, Christopher J. , Smith, Nicholas L. , Strachan, David P. , Dehghan, Abbas , Attia, John R.
- Resource Type: journal article
- Date: 2017
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
- Creator: Iglesias, Adriana I. , Mishra, Aniket , Vitart, Veronique , Bykhovskaya, Yelena , Höhn, René , Springelkamp, Henriët , Cuellar-Partida, Gabriel , Gharahkhani, Puya , Bailey, Jessica N. Cooke , Willoughby, Colin E. , Li, Xiaohui , Yazar, Seyhan , Nag, Abhishek , Khawaja, Anthony P. , Polašek, Ozren , Siscovick, David , Mitchell, Paul , Tham, Yin Chung , Haines, Jonathan L. , Kearns, Lisa S. , Hayward, Caroline , Shi, Yuan , van Leeuwen, Elisabeth M. , Taylor, Kent D. , Wang, Jie Jin , Rochtchina, Elena , Attia, John , Scott, Rodney , Holliday, Elizabeth G. , Baird, Paul N. , Xie, Jing , Inouye, Michael , Viswanathan, Ananth , Sim, Xueling , Bonnemaijer, Pieter , Rotter, Jerome I. , Martin, Nicholas G. , Zeller, Tanja , Mills, Richard A. , Staffieri, Sandra E. , Jonas, Jost B. , Schmidtmann, Irene , Boutin, Thibaud , Kang, Jae H. , Lucas, Sionne E. M. , Wong, Tien Yin , Beutel, Manfred E. , Wilson, James F. , Allingham, R. Rand , Brilliant, Murray H. , Budenz, Donald L. , Christen, William G. , Fingert, John , Friedman, David S. , Gaasterland, Douglas , Gaasterland, Terry , Hauser, Michael A. , Kraft, Peter , Lee, Richard K. , Lichter, Paul R. , Liu, Yutao , Loomis, Stephanie J. , Moroi, Sayoko E. , Pericak-Vance, Margaret A. , Realini, Anthony , Richards, Julia E. , Schuman, Joel S. , Scott, William K. , Singh, Kuldev , Sit, Arthur J. , Vollrath, Douglas , Weinreb, Robert N. , Wollstein, Gadi , Zack, Donald J. , Zhang, Kang
- Resource Type: journal article
- Date: 2018
Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study
- Creator: Tan, Jennifer S. L. , Wang, Jie Jin , Flood, Victoria , Rochtchina, Elena , Smith, Wayne , Mitchell, Paul
- Resource Type: journal article
- Date: 2008
Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study
- Creator: Tan, Ava Grace , Kifley, Annette , Flood, Victoria M. , Holliday, Elizaeth G. , Scott, Rodney J. , Cumming, Robert G. , Mitchell, Paul , Wang, Jie Jin
- Resource Type: journal article
- Date: 2019
Examination of the association between mental health, morbidity, and mortality in late life: findings from longitudinal community surveys
- Creator: Burns, Richard A. , Butterworth, Peter , Browning, Colette , Byles, Julie , Luszcz, Mary , Mitchell, Paul , Shaw, Jonathan , Anstey, Kaarin J.
- Resource Type: journal article
- Date: 2015
Examining the SF-36 in an older population: analysis of data and presentation of Australian adult reference scores from the Dynamic Analyses to Optimise Ageing (DYNOPTA) project
- Creator: Bartsch, Lauren J. , Butterworth, Peter , Byles, Julie E. , Mitchell, Paul , Shaw, Jonathan , Anstey, Kaarin J.
- Resource Type: journal article
- Date: 2011
Exploring Factors Underlying Ethnic Difference in Age-related Macular Degeneration Prevalence
- Creator: Jones, Mark , Whitton, Clare , Teo, Yik-Ying , Mitchell, Paul , Wong, Tien Y. , Tai, E. Shyong , Van Dam, Rob M. , Attia, John , Wang, Jie Jin , Tan, Ava G. , Holliday, Elizabeth G. , Oldmeadow, Christopher , Flood, Victoria M. , Sim, Xueling , Chai, Jin-Fang , Hamzah, Haslina , Klein, Ronald
- Resource Type: journal article
- Date: 2020
Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the three continent AMD consortium report
- Creator: Joachim, Nichole , Colijn, Johanna Maria , Attia, John , Liew, Gerald , Iyengar, Sudha K. , De Jong, Paulus T. V. M. , Hofman, Albert , Vingerling, Johannes R. , Mitchell, Paul , Klaver, Caroline C. W. , Klein, Ronald , Wang, Jie Jin , Kifley, Annette , Lee, Kristine E. , Buitendijk, Gabriëlle H. S. , Klein, Barbara E. K. , Myers, Chelsea E. , Meuer, Stacy M. , Tan, Ava G. , Holliday, Elizabeth G.
- Resource Type: journal article
- Date: 2017
Frequency of fish consumption, retinal microvascular signs and vascular mortality
- Creator: Kaushik, Shweta , Wang, Jie Jin , Flood, Victoria , Liew, Gerald , Smith, Wayne , Mitchell, Paul
- Resource Type: journal article
- Date: 2008
Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study Cohort
- Creator: Schache, Maria , Richardson, Andrea J. , Sim, Xueling , Holliday, Elizabeth G. , Attia, John , Scott, Rodney J. , Baird, Paul N. , Mitchell, Paul , Wang, Jie Jin , Rochtchina, Elena , Viswanathan, Anath C. , Wong, Tien Y. , Saw, Seang Mei , Topouzis, Fotis , Xie, Jing
- Resource Type: journal article
- Date: 2013
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- Creator: Pattaro, Cristian , Teumer, Alexander , Taliun, Daniel , Wallaschofski, Henri , Vöelzke, Henry , Brenner, Hermann , Kroemer, Heyo K. , Kramer, Holly , Lin, Honghuang , Leach, I. Mateo , Ford, Ian , Guessous, Idris , Rudan, Igor , Olden, Matthias , Prokopenko, Inga , Borecki, Ingrid , Heid, Iris M. , Kolcic, Ivana , Persico, Ivana , Jukema, J. Wouter , Wilson, James F. , Felix, Janine F. , Divers, Jasmin , Lambert, Jean-Charles , Foster, Meredith , Stafford, Jeanette M. , Gaspoz, Jean-Michel , Smith, Jennifer A. , Faul, Jessica D. , Wang, Jie Jin , Ding, Jingzhong , Hirschhorn, Joel N. , Attia, John , Whitfield, John B. , Chalmers, John , Yang, Qiong , Viikari, Jorma , Coresh, Josef , Denny, Joshua C. , Karjalainen, Juha , Fernandes, Jyotika K. , Endlich, Karlhans , Butterbach, Katja , Keene, Keith L. , Lohman, Kurt , Portas, Laura , Chen, Ming-Huei , Launer, Lenore J. , Lyytikäinen, Leo-Pekka , Yengo, Loic , Franke, Lude , Ferrucci, Luigi , Rose, Lynda M. , Kedenko, Lyudmyla , Rao, Madhumathi , Struchalin, Maksim , Kleber, Marcus E. , Pers, Tune H. , Cavalieri, Margherita , Haun, Margot , Cornelis, Marilyn C. , Ciullo, Marina , Pirastu, Mario , de Andrade, Mariza , McEvoy, Mark A. , Woodward, Mark , Adam, Martin , Cocca, Massimiliano , Johnson, Andrew D. , Nauck, Matthias , Imboden, Medea , Waldenberger, Melanie , Pruijm, Menno , Metzger, Marie , Stumvoll, Michael , Evans, Michele K. , Sale, Michele M. , Käehöenen, Mika , Boban, Mladen , Ko, Yi-An , Bochud, Murielle , Rheinberger, Myriam , Verweij, Niek , Bouatia-Naji, Nabila , Martin, Nicholas G. , Hastie, Nick , Probst-Hensch, Nicole , Soranzo, Nicole , Devuyst, Olivier , Raitakari, Olli , Fuchsberger, Christian , Gottesman, Omri , Franco, Oscar H. , Polasek, Ozren , Gasparini, Paolo , Munroe, Patricia B. , Ridker, Paul M. , Mitchell, Paul , Muntner, Paul , Meisinger, Christa , Smit, Johannes H. , Tayo, Bamidele , Kovacs, Peter , Wild, Philipp S. , Froguel, Philippe , Rettig, Rainer , Mäegi, Reedik , Biffar, Reiner , Schmidt, Reinhold , Middelberg, Rita P. S. , Carroll, Robert J. , Penninx, Brenda W. , Gorski, Mathias , Nalls, Michael , Scott, Rodney J. , Katz, Ronit , Sedaghat, Sanaz , Wild, Sarah H. , Kardia, Sharon L. R. , Ulivi, Sheila , Hwang, Shih-Jen , Enroth, Stefan , Kloiber, Stefan , Trompet, Stella , Feitosa, Mary F. , Stengel, Benedicte , Hancock, Stephen J. , Turner, Stephen T. , Rosas, Sylvia E. , Stracke, Sylvia , Harris, Tamara B. , Zeller, Tanja , Zemunik, Tatijana , Lehtimäki, Terho , Illig, Thomas , Isaacs, Aaron , Aspelund, Thor , Nikopensius, Tiit , Esko, Tonu , Tanaka, Toshiko , Gyllensten, Ulf , Völker, Uwe , Emilsson, Valur , Vitart, Veronique , Aalto, Ville , Gudnason, Vilmundur , Dehghan, Abbas , Chouraki, Vincent , Chen, Wei-Min , Igl, Wilmar , März, Winfried , Koenig, Wolfgang , Lieb, Wolfgang , Loos, Ruth J. F. , Liu, Yongmei , Snieder, Harold , Pramstaller, Peter P. , d'Adamo, Pio , Parsa, Afshin , O'Connell, Jeffrey R. , Susztak, Katalin , Hamet, Pavel , Tremblay, Johanne , de Boer, Ian H. , Böger, Carsten A. , Goessling, Wolfram , Chasman, Daniel I. , Köttgen, Anna , Adeyemo, Adebowale , Kao, W. H. Linda , Fox, Caroline S. , ICBP Consortium , AGEN Consortium , CARDIOGRAM , CHARGe-Heart Failure Group , ECHOGen Consortium , Dieffenbach, Aida Karina , Zonderman, Alan B. , Nolte, Ilja M. , van der Most, Peter J. , Chu, Audrey Y. , Wright, Alan F. , Shuldiner, Alan R. , Morrison, Alanna C. , Hofman, Albert , Smith, Albert V. , Dreisbach, Albert W. , Franke, Andre , Uitterlinden, Andre G. , Metspalu, Andres , Tonjes, Anke , Li, Man , Lupo, Antonio , Robino, Antonietta , Johansson, Åsa , Demirkan, Ayse , Kollerits, Barbara , Freedman, Barry I. , Ponte, Belen , Oostra, Ben A. , Paulweber, Bernhard , Kräemer, Bernhard K. , Mijatovic, Vladan , Mitchell, Braxton D. , Buckley, Brendan M. , Peralta, Carmen A. , Hayward, Caroline , Helmer, Catherine , Rotimi, Charles N. , Shaffer, Christian M. , Müeller, Christian , Sala, Cinzia , van Duijn, Cornelia M. , Garnaas, Maija , Saint-Pierre, Aude , Ackermann, Daniel , Shriner, Daniel , Ruggiero, Daniela , Toniolo, Daniela , Lu, Yingchang , Cusi, Daniele , Czamara, Darina , Ellinghaus, David , Siscovick, David S. , Tin, Adrienne , Ruderfer, Douglas , Gieger, Christian , Grallert, Harald , Rochtchina, Elena , Atkinson, Elizabeth J. , Holliday, Elizabeth G. , Boerwinkle, Eric , Salvi, Erika , Bottinger, Erwin P. , Murgia, Federico , Sorice, Rossella , Rivadeneira, Fernando , Ernst, Florian , Kronenberg, Florian , Hu, Frank B. , Navis, Gerjan J. , Curhan, Gary C. , Ehret, George B. , Homuth, Georg , Coassin, Stefan , Thun, Gian-Andri , Li, Yong , Pistis, Giorgio , Gambaro, Giovanni , Malerba, Giovanni , Montgomery, Grant W. , Eiriksdottir, Gudny , Jacobs, Gunnar , Li, Guo , Wichmann, H-Erich , Campbell, Harry , Schmidt, Helena
- Resource Type: journal article
- Date: 2016
Genetic loci for retinal arteriolar microcirculation
- Creator: Sim, Xueling , Jensen, Richard A. , Klein, Ronald , Klein, Barbara E. K. , Glazer, Nicole L. , Lumley, Thomas , McKnight, Barbara , Psaty, Bruce M. , de Jong, Paulus T. V. M. , Hofman, Albert , Rivadeneira, Fernando , Uitterlinden, Andre G. , Ikram, M. Kamran , van Duijn, Cornelia M. , Aspelund, Thor , Eiriksdottir, Gudny , Harris, Tamara B. , Jonasson, Fridbert , Launer, Lenore J. , The Wellcome Trust Case Control Consortium , Attia, John , Baird, Paul N. , Harrap, Stephen , Cotch, Mary Frances , Holliday, Elizabeth G. , Inouye, Michael , Rochtchina, Elena , Scott, Rodney J. , Viswanathan, Ananth , Global BPGen Consortium , Li, Guo , Smith, Nicholas L. , Wiggins, Kerri L. , Kuo, Jane Z. , Li, Xiaohui , Taylor, Kent D. , Hewitt, Alex W. , Martin, Nicholas G. , Montgomery, Grant W. , Sun, Cong , Young, Terri L. , Mackey, David A. , van Zuydam, Natalie R. , Doney, Alex S. F. , Palmer, Colin N. A. , MacGregor, Stuart , Morris, Andrew D. , Rotter, Jerome I. , Tai, E. Shyong , Gudnason, Vilmundur , Vingerling, Johannes R. , Siscovick, David S. , Wang, Jie Jin , Wong, Tien Y. , Xie, Jing , Smith, Albert Vernon , Boerwinkle, Eric , Mitchell, Paul
- Resource Type: journal article
- Date: 2013
Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations
- Creator: Wang, Jie Jin , Buitendijk, Gabriëlle H. S. , Holliday, Elizabeth G. , Tan, Ava G. , Smith, Wayne T. , Iyengar, Sudha K. , de Jong, Paulus T. V. M. , Hofman, Albert , Vingerling, Johannes R. , Mitchell, Paul , Klein, Ronald , Klaver, Caroline C. W. , Rochtchina, Elena , Lee, Kristine E. , Klein, Barbara E. K. , van Duijn, Cornelia M. , Flood, Victoria M. , Meuer, Stacy M. , Attia, John , Myers, Chelsea
- Resource Type: journal article
- Date: 2014
Genome-wide association and functional follow-up reveals new loci for kidney function
- Creator: Pattaro, Cristian , Kottgen, Anna , Li, Man , Uitterlinden, Andre G. , Rivadeneira, Fernando , Aulchenko, Yurii S. , Polasek, Ozren , Hastie, Nick , Vitart, Veronique , Helmer, Catherine , Wang, Jie Jin , Ruggiero, Daniela , Bergmann, Sven , Gao, Xiaoyi , Kahonen, Mika , Viikari, Jorma , Nikopensius, Tiit , Province, Michael , Ketkar, Shamika , Colhoun, Helen , Doney, Alex , Robino, Antonietta , Giulianini, Franco , Kramer, Bernhard K. , Gorski, Mathias , Portas, Laura , Ford, Ian , Buckley, Brendan M. , Adam, Martin , Thun, Gian-Andri , Paulweber, Bernhard , Haun, Margot , Sala, Cinzia , Metzger, Marie , Mitchell, Paul , Yang, Qiong , Ciullo, Marina , King, Stuart K. , Vollenweider, Peter , Raitakari, Olli , Metspalu, Andres , Palmer, Colin , Gasparini, Paolo , Pirastu, Mario , Jukema, J. Wouter , Probst-Hensch, Nicole M. , Hundertmark, Claudia , Kronenberg, Florian , Toniolo, Daniela , Gudnason, Vilmundur , Shuldiner, Alan R. , Coresh, Josef , Schmidt, Reinhold , Ferrucci, Luigi , Siscovick, David S. , van Duijn, Cornelia M. , Borecki, Ingrid , Foster, Meredith C. , Kardia, Sharon L. R. , Liu, Yongmei , Curhan, Gary C. , Rudan, Igor , Gyllensten, Ulf , Wilson, James F. , Franke, Andre , Pramstaller, Peter P. , Retting, Rainer , Prokopenko, Inga , O'Seaghdha, Conall M. , Witteman, Jacqueline C. M. , Hayward, Caroline , Ridker, Paul , Parsa, Afshin , Bochud, Murielle , Heid, Iris M. , Goessling, Wolfram , Chasman, Daniel I. , Kao, W. H. Linda , Fox, Caroline S. , Glazer, Nicole , Isaacs, Aaron , Liu, Ching-Ti , Teumer, Alexander , Smith, Albert V. , O'Connell, Jeffrey R. , Struchalin, Maksim , Tanaka, Toshiko , Li, Guo , Johnson, Andrew D. , Gierman, Hinco J. , Feitosa, Mary , Hwang, Shih-Jen , Atkinson, Elizabeth J. , Garnaas, Maija , Lohman, Kurt , Cornelis, Marilyn C. , Johansson, Asa , Tonjes, Anke , Dehghan, Abbas , Chouraki, Vincent , Holliday, Elizabeth G. , Sorice, Rossella , Kutalik, Zoltan , Lehtimaki, Terho , Boger, Carsten A. , Esko, Tonu , Deshmukh, Harshal , Ulivi, Sheila , Chu, Audrey Y. , Murgia, Federico , Trompet, Stella , Imboden, Medea , Kollerits, Barbara , Pistis, Giorgio , CARDIoGRAM Consortium , Fuchsberger, Christian , ICBP Consortium , CARe Consortium , Wellcome Trust Case Control Consortium 2 (WTCCC2) , Harris, Tamara B. , Launer, Lenore J. , Aspelund, Thor , Eiriksdottir, Gudny , Mitchell, Braxton D. , Boerwinkle, Eric , Schmidt, Helena , Olden, Matthias , Cavalieri, Margherita , Rao, Madhumathi , Hu, Frank B. , Demirkan, Ayse , Oostra, Ben A. , de Andrade, Mariza , Turner, Stephen T. , Ding, Jingzhong , Andrews, Jeanette S. , Freedma, Barry I. , Chen, Ming-Huei , Koenig, Wolfgang , Illig, Thomas , Doring, Angela , Wichmann, H.-Erich , Kolcic, Ivana , Zemunik, Tatijana , Boban, Mladen , Minelli, Cosetta , Wheeler, Heather E. , Igl, Wilmar , Tin, Adrienne , Zaboli, Ghazal , Wild, Sarah H. , Wright, Alan F. , Campbell, Harry , Ellinghaus, David , Nothlings, Ute , Jacobs, Gunnar , Biffar, Reiner , Endlich, Karlhans , Ernst, Florian , Taliun, Daniel , Homuth, Georg , Kroemer, Heyo K. , Nauck, Matthias , Stracke, Sylvia , Volker, Uwe , Volzke, Henry , Kovacs, Peter , Stumvoll, Michael , Magi, Reedik , Hofman, Albert
- Resource Type: journal article
- Date: 2012