First-in-class inhibitor of ribosomal RNA synthesis with antimicrobial activity against Staphylococcus aureus
- Creator: Yang, Xiao , Luo, Ming Jing , Yeung, Apple C. M. , Lewis, Peter J. , Chan, Paul K. S. , Ip, Margaret , Ma, Cong
- Resource Type: journal article
- Date: 2017
Small molecule inhibitors of bacterial transcription complex formation
- Creator: Wenholz, Daniel S. , Zeng, Ming , Ma, Cong , Mielczarek, Marcin , Yang, Xiao , Bhadbhade, Mohan , Black, David St. C. , Lewis, Peter J. , Griffith, Renate , Kumar, Naresh
- Resource Type: journal article
- Date: 2017
Small-molecule inhibitors of the NusB-NusE protein-protein interaction with antibiotic activity
- Creator: Cossar, Peter J. , Abdel-Hamid, Mohammed K. , Ma, Cong , Sakoff, Jennette A. , Trinh, Trieu N. , Gordon, Christopher P. , Lewis, Peter J. , McCluskey, Adam
- Resource Type: journal article
- Date: 2017
Synthesis and antibacterial evaluation of novel 3-substituted ocotillol-type derivatives as leads
- Creator: Bi, Yi , Liu, Xian-Xuan , Ma, Cong , Yuan, Chun-Su , Zhang, Heng-Yuan , Yang, Xiao , Liu, Ze-Yun , Lu, Jing , Lewis, Peter John , Wang, Chong-Zhi , Xu, Jin-Yi , Meng, Qing-Guo
- Resource Type: journal article
- Date: 2017
Bacterial transcription as a target for antibacterial drug development
- Creator: Ma, Cong , Yang, Xiao , Lewis, Peter J.
- Resource Type: journal article
- Date: 2016
Bacterial transcription inhibitor of RNA polymerase holoenzyme formation by structure-based drug design: from in silico screening to validation
- Creator: Ma, Cong , Yang, Xiao , Lewis, Peter J.
- Resource Type: journal article
- Date: 2016
Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives
- Creator: Ma, Cong , Letort, Aurélien , Aouzal, Rémi , Wilkes, Antonia , Maiti, Gourhari , Farrugia, Louis J. , Ricard, Louis , Prunet, Joëlle
- Resource Type: journal article
- Date: 2016
From indole to pyrrole, furan, thiophene and pyridine: search for novel small molecule inhibitors of bacterial transcription initiation complex formation
- Creator: Thach, Oscar , Mielczarek, Marcin , Ma, Cong , Kutty, Samuel K. , Yang, Xiao , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2016
In vitro transcription assays and their application in drug discovery
- Creator: Yang, Xiao , Ma, Cong
- Resource Type: journal article
- Date: 2016
Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs.
- Creator: Yin, Zhou , Whittell, Louise R. , Wang, Yao , Jergic, Slobodan , Ma, Cong , Lewis, Peter J. , Dixon, Nicholas E. , Beck, Jennifer L. , Kelso, Michael J. , Oakley, Aaron J.
- Resource Type: journal article
- Date: 2015
Design, synthesis and in vitro NO-releasing activities of ocotillol-type furoxans
- Creator: Bi, Yi , Yang, Jian , Ma, Cong , Liu, Ze-Yun , Zhang, Ting-Ting , Zhang, Xiao-Chen , Lu, Jing , Meng, Qing-Guo
- Resource Type: journal article
- Date: 2015
Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives
- Creator: Bi, Yi , Yang, Xiao , Lewis, Peter John , Meng, Qingguo , Ma, Cong , Zhang, Tingting , Liu, Zeyun , Zhang, Xiaochen , Lu, Jing , Cheng, Keguang , Xu, Jinyi , Wang, Hongbo , Lv, Guangyao
- Resource Type: journal article
- Date: 2015
Identification of inhibitors of bacterial RNA polymerase
- Creator: Yang, Xiao , Ma, Cong , Lewis, Peter J.
- Resource Type: journal article
- Date: 2015
RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.
- Creator: Ma, Cong , Mobli, Mehdi , Yang, Xiao , Keller, Andrew N. , King, Glenn F. , Lewis, Peter J.
- Resource Type: journal article
- Date: 2015
Synthesis and antibacterial evaluation of novel hydrophilic ocotillol-type triterpenoid derivatives from 20(S)-protopanaxadiol
- Creator: Bi, Yi , Ma, Cong , Zhou, Zhiwen , Zhang, Tingting , Zhang, Hengyuan , Zhang, Xiaochen , Lu, Jing , Meng, Qingguo , Lewis, Peter J. , Xu, Jinyi
- Resource Type: journal article
- Date: 2015
Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation
- Creator: Mielczarek, Marcin , Thomas, Ruth V. , Ma, Cong , Kandemir, Hakan , Yang, Xiao , Bhadbhade, Mohan , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2015
A vector system that allows simple generation of mutant Escherichia coli RNA polymerase
- Creator: Yang, Xiao , Ma, Cong , Lewis, Peter
- Resource Type: journal article
- Date: 2014
Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis
- Creator: Letort, Aurelien , Aouzal, Remi , Ma, Cong , Long, De-Liang , Prunet, Joelle
- Resource Type: journal article
- Date: 2014
Novel 3-substituted ocotillol-type triterpenoid derivatives as antibacterial candidates
- Creator: Bi, Yi , Ma, Cong , Zhang, Hengyuan , Zhou, Zhiwen , Yang, Jian , Zhang, Zhenlei , Meng, Qingguo , Lewis, Peter J. , Xu, Jinyi
- Resource Type: journal article
- Date: 2014
Synthesis and biological activity of novel bis-indole inhibitors of bacterial transcription initiation complex formation
- Creator: Mielczarek, Marcin , Devakaram, Ruth V. , Ma, Cong , Yang, Xiao , Kandemir, Hakan , Purwono, Bambang , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2014