Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD
- Creator: Larsen, Joachim S. , Miller, Michael , Oakley, Aaron J. , Dixon, Nicholas E. , Lewis, Peter J.
- Resource Type: journal article
- Date: 2021
Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD
- Creator: Newing, Timothy P. , Oakley, Aaron J. , Miller, Michael , Dawson, Catherine J. , Brown, Simon H. J. , Bouwer, James C. , Tolun, Gokhan , Lewis, Peter J.
- Resource Type: journal article
- Date: 2020
Protein-protein interactions as antibiotic targets: a medicinal chemistry perspective
- Creator: Cossar, Peter J. , Lewis, Peter J. , McCluskey, Adam
- Resource Type: journal article
- Date: 2020
First-in-class inhibitor of ribosomal RNA synthesis with antimicrobial activity against Staphylococcus aureus
- Creator: Yang, Xiao , Luo, Ming Jing , Yeung, Apple C. M. , Lewis, Peter J. , Chan, Paul K. S. , Ip, Margaret , Ma, Cong
- Resource Type: journal article
- Date: 2017
Identification and validation of small molecule modulators of the NusB-NusE interaction
- Creator: Cossar, Peter J. , Cong, Ma , Gordon, Christopher P. , Ambrus, Joseph I. , Lewis, Peter J. , McCluskey, Adam
- Resource Type: journal article
- Date: 2017
In-culture cross-linking of bacterial cells reveals large-scale dynamic protein-protein interactions at the peptide level
- Creator: de Jong, Luitzen , de Koning, Edward A. , Hamoen, Leendert W. , de Koster, Chris G. , Roseboom, Winfried , Buncherd, Hansuk , Wanner, Martin J. , Dapic, Irena , Jansen, Petra J. , van Maarseveen, Jan H. , Corthals, Garry L. , Lewis, Peter J.
- Resource Type: journal article
- Date: 2017
Small molecule inhibitors of bacterial transcription complex formation
- Creator: Wenholz, Daniel S. , Zeng, Ming , Ma, Cong , Mielczarek, Marcin , Yang, Xiao , Bhadbhade, Mohan , Black, David St. C. , Lewis, Peter J. , Griffith, Renate , Kumar, Naresh
- Resource Type: journal article
- Date: 2017
Small-molecule inhibitors of the NusB-NusE protein-protein interaction with antibiotic activity
- Creator: Cossar, Peter J. , Abdel-Hamid, Mohammed K. , Ma, Cong , Sakoff, Jennette A. , Trinh, Trieu N. , Gordon, Christopher P. , Lewis, Peter J. , McCluskey, Adam
- Resource Type: journal article
- Date: 2017
Activation of Xer-recombination at dif: structural basis of the FtsKγ-XerD interaction
- Creator: Keller, Andrew N. , Xin, Yue , Boer, Stephanie , Reinhardt, Jonathan , Baker, Rachel , Arciszewska, Lidia K. , Lewis, Peter J. , Sherratt, David J. , Löwe, Jan , Grainge, Ian
- Resource Type: journal article
- Date: 2016
Bacterial transcription as a target for antibacterial drug development
- Creator: Ma, Cong , Yang, Xiao , Lewis, Peter J.
- Resource Type: journal article
- Date: 2016
Bacterial transcription inhibitor of RNA polymerase holoenzyme formation by structure-based drug design: from in silico screening to validation
- Creator: Ma, Cong , Yang, Xiao , Lewis, Peter J.
- Resource Type: journal article
- Date: 2016
From indole to pyrrole, furan, thiophene and pyridine: search for novel small molecule inhibitors of bacterial transcription initiation complex formation
- Creator: Thach, Oscar , Mielczarek, Marcin , Ma, Cong , Kutty, Samuel K. , Yang, Xiao , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2016
Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs.
- Creator: Yin, Zhou , Whittell, Louise R. , Wang, Yao , Jergic, Slobodan , Ma, Cong , Lewis, Peter J. , Dixon, Nicholas E. , Beck, Jennifer L. , Kelso, Michael J. , Oakley, Aaron J.
- Resource Type: journal article
- Date: 2015
Identification of inhibitors of bacterial RNA polymerase
- Creator: Yang, Xiao , Ma, Cong , Lewis, Peter J.
- Resource Type: journal article
- Date: 2015
RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.
- Creator: Ma, Cong , Mobli, Mehdi , Yang, Xiao , Keller, Andrew N. , King, Glenn F. , Lewis, Peter J.
- Resource Type: journal article
- Date: 2015
Synthesis and antibacterial evaluation of novel hydrophilic ocotillol-type triterpenoid derivatives from 20(S)-protopanaxadiol
- Creator: Bi, Yi , Ma, Cong , Zhou, Zhiwen , Zhang, Tingting , Zhang, Hengyuan , Zhang, Xiaochen , Lu, Jing , Meng, Qingguo , Lewis, Peter J. , Xu, Jinyi
- Resource Type: journal article
- Date: 2015
Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation
- Creator: Mielczarek, Marcin , Thomas, Ruth V. , Ma, Cong , Kandemir, Hakan , Yang, Xiao , Bhadbhade, Mohan , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2015
AtfA, a new factor in global regulation of transcription in Acinetobacter spp
- Creator: Withers, Ryan , Doherty, Geoff P. , Jordan, Matthew , Yang, Xiao , Dixon, Nicholas E. , Lewis, Peter J.
- Resource Type: journal article
- Date: 2014
Novel 3-substituted ocotillol-type triterpenoid derivatives as antibacterial candidates
- Creator: Bi, Yi , Ma, Cong , Zhang, Hengyuan , Zhou, Zhiwen , Yang, Jian , Zhang, Zhenlei , Meng, Qingguo , Lewis, Peter J. , Xu, Jinyi
- Resource Type: journal article
- Date: 2014
Synthesis and biological activity of novel bis-indole inhibitors of bacterial transcription initiation complex formation
- Creator: Mielczarek, Marcin , Devakaram, Ruth V. , Ma, Cong , Yang, Xiao , Kandemir, Hakan , Purwono, Bambang , Black, David StC. , Griffith, Renate , Lewis, Peter J. , Kumar, Naresh
- Resource Type: journal article
- Date: 2014