Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes
Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse
- Jamsai, Duangporn, O'Connor, Anne E., Jones, Keith T., O'Bryan, Moira K., DeBoer, Kathleen D., Clark, Brett J., Smith, Stephanie J., Browne, Catherine M., Bensley, Jonathan G., Merriman, Julie A., Yuen, Wai Shan, Koopman, Peter
APC FZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes
The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension
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