Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Creator: Keaton, Jacob M. , Kamali, Zoha , Young, William J. , Lehtimäki, T , Raitakari, OT , Johnson, AD , Newton-Cheh, C , Brown, MJ , Dominiczak, AF , Sever, PJ , Poulter, N , Chambers, JC , Elosua, R , Traylor, Matthew , Siscovick, D , Esko, T , Metspalu, A , Strawbridge, RJ , Laakso, M , Hamsten, A , Hottenga, J-J , de Geus, E , Morris, AD , Palmer, CNA , Giri, Ayush , Nolte, IM , Milaneschi, Y , Marten, J , Wright, A , Zeggini, E , Howson, JMM , O'Donnell, CJ , Spector, T , Nalls, MA , Simonsick, EM , Zheng, Zhili , Liu, Y , van Duijn, CM , Butterworth, AS , Danesh, JN , Menni, C , Wareham, NJ , Khaw, K-T , Sun, YV , Wilson, PWF , Cho, K , Zeng, Jian , Visscher, PM , Denny, JC , Million Veteran Program, , Lifelines Cohort Study, , CHARGE consortium, , ICBP Consortium, , Levy, D , Edwards, TL , Munroe, PB , Snieder, H , Chasman, Daniel I. , Warren, HR , Morris, Andrew P. , Caulfield, Mark J. , Hwang, Shih-Jen , Kooner, Jaspal S. , Xie, Tian , Attia, John R. , Attia, JR , Morrison, AC , Loos, RJF , Kristiansson, K , Schmidt, R , Hicks, AA , Pramstaller, PP , Nelson, CP , Samani, NJ , Vaez, Ahmad , Risch, L , Gyllensten, U , Melander, O , Riese, H , Wilson, JF , Campbell, H , Rich, SS , Psaty, BM , Lu, Y , Rotter, JI , Williams, Ariel , Guo, X , Rice, KM , Vollenweider, P , Sundström, J , Langenberg, C , Tobin, MD , Giedraitis, V , Luan, J , Tuomilehto, J , Kutalik, Z , Goleva, Slavina B. , Ripatti, S , Salomaa, V , Girotto, G , Trompet, S , Jukema, JW , van der Harst, P , Ridker, PM , Giulianini, F , Vitart, V , Goel, A , Ani, Alireza , Watkins, H , Harris, SE , Deary, IJ , van der Most, PJ , Oldehinkel, AJ , Keavney, BD , Hayward, C , Campbell, A , Boehnke, M , Scott, LJ , Evangelou, Evangelos , Boutin, T , Mamasoula, C , Järvelin, M-R , Peters, A , Gieger, C , Lakatta, EG , Cucca, F , Hui, J , Knekt, P , Enroth, S , Hellwege, Jacklyn N. , De Borst, MH , Polašek, O , Concas, MP , Catamo, E , Cocca, M , Li-Gao, R , Hofer, E , Schmidt, H , Spedicati, B , Waldenberger, M , Yengo, Loic , Strachan, DP , Laan, M , Teumer, A , Dörr, M , Gudnason, V , Cook, JP , Ruggiero, D , Kolcic, I , Boerwinkle, E , Traglia, M
- Resource Type: journal article
- Date: 2024
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
- Creator: Temprano-Sagrera, Gerard , Sitlani, Colleen M. , Dehghan, Abbas , Heath, Adam S. , Reiner, Alex P. , Johnson, Andrew , Richmond, Anne , Peters, Annette , van Hylckama Vlieg, Astrid , McKnight, Barbara , Psaty, Bruce M. , Hayward, Caroline , Bone, William P. , Holliday, Elizabeth G. , Attia, John , Levi, Christopher R. , Chasman, D , Strachan, DP , Tregouet, DA , Mook-Kanamori, D , Gill, D , Thibord, F , Asselbergs, FW , Martin-Bornez, Miguel , Leebeek, FWG , Rosendaal, FR , Davies, G , Homuth, G , Temprano, G , Campbell, H , Taylor, HA , Bressler, J , Huffman, JE , Rotter, JI , Voight, Benjamin F. , Yao, J , Wilson, JF , Bis, JC , Hahn, JM , Desch, KC , Wiggins, KL , Raffield, LM , Bielak, LF , Yanek, LR , Kleber, ME , Morrison, Alanna C. , Sabater-Lleal, M , Mueller, M , Kavousi, M , Mangino, M , Liu, M , Brown, MR , Conomos, MP , Jhun, MA , Chen, MH , de Maat, MPM , Damrauer, Scott M. , Pankratz, N , Peyser, PA , Elliot, P , Wei, P , Wild, PS , Morange, PE , van der Harst, P , Yang, Q , Le, NQ , Marioni, R , de Vries, Paul S. , Li, R , Damrauer, SM , Cox, SR , Trompet, S , Felix, SB , Völker, U , Tang, W , Koenig, W , Jukema, JW , Guo, X , Smith, Nicholas L. , Lindstrom, S , Wang, L , Smith, EN , Gordon, W , van Hylckama Vlieg, A , de Andrade, M , Brody, JA , Pattee, JW , Haessler, J , Brumpton, BM , Sabater-Lleal, Maria , Chasman, DI , Suchon, P , Turman, C , Germain, M , MacDonald, J , Braekkan, SK , Armasu, SM
- Resource Type: journal article
- Date: 2022
Associations of autozygosity with a broad range of human phenotypes
- Creator: Clark, David W. , Cocca, M , Collins, FS , Concas, MP , Corley, J , Cugliari, G , Van Dam, RM , Damulina, A , Daneshpour, MS , Day, FR , Delgado, GE , Dhana, K , Doney, ASF , Doerr, M , Doumatey, AP , Dzimiri, N , Ebenesersdottir, SS , Elliott, J , Elliott, P , Ewert, R , Felix, JF , Fischer, K , Freedman, BI , Girotto, G , Goel, A , Gogele, M , Goodarzi, MO , Graff, M , Granot-Hershkovitz, E , Grodstein, F , Guarrera, S , Gudbjartsson, DF , Guity, K , Gunnarsson, B , Guo, Y , Hagenaars, SP , Haiman, CA , Halevy, A , Harris, TB , Hedayati, M , van Heel, DA , Hirata, M , Hofer, I , Hsiung, CA , Huang, J , Hung, Y-J , Ikram, MA , Jagadeesan, A , Jousilahti, P , Kamatani, Y , Kanai, M , Kerrison, ND , Kessler, T , Khaw, K-T , Khor, CC , de Kleijn, DPV , Koh, W-P , Kolcic, I , Kraft, P , Kramer, BK , Kutalik, Z , Kuusisto, J , Langenberg, C , Launer, LJ , Lawlor, DA , Lee, I-T , Lee, W-J , Lerch, MM , Li, L , Liu, J , Loh, M , London, SJ , Loomis, S , Lu, Y , Luan, J , Magi, R , Manichaikul, AW , Manunta, P , Masson, G , Matoba, N , Mei, XW , Meisinger, C , Meitinger, T , Mezzavilla, M , Milani, L , Millwood, IY , Momozawa, Y , Moore, A , Morange, P-E , Moreno-Macias, H , Mori, TA , Morrison, AC , Muka, T , Murakami, Y , Murray, AD , de Mutsert, R , Mychaleckyj, JC , Nalls, MA , Nauck, M , Neville, MJ , Nolte, IM , Ong, KK , Orozco, L , Padmanabhan, S , Palsson, G , Pankow, JS , Pattaro, C , Pattie, A , Polasek, O , Poulter, N , Pramstaller, PP , Quintana-Murci, L , Raikkonen, K , Ralhan, S , Rao, DC , van Rheenen, W , Rich, SS , Ridker, PM , Rietveld, CA , Robino, A , van Rooij, FJA , Ruggiero, D , Saba, Y , Sabanayagam, C , Sabater-Lleal, M , Felicita Sala, C , Salomaa, V , Sandow, K , Schmidt, H , Scott, LJ , Scott, WR , Sedaghati-Khayat, B , Sennblad, B , van Setten, J , Sever, PJ , Sheu, WH-H , Shi, Y , Shrestha, S , Shukla, SR , Sigurdsson, JK , Sikka, TT , Singh, JR , Smith, BH , Stancakova, A , Stanton, A , Starr, JM , Stefansdottir, L , Straker, L , Sulem, P , Sveinbjornsson, G , Swertz, MA , Taylor, AM , Taylor, KD , Terzikhan, N , Tham, Y-C , Thorleifsson, G , Thorsteinsdottir, U , Tillander, A , Tracy, RP , Tusie-Luna, T , Tzoulaki, I , Vaccargiu, S , Vangipurapu, J , Veldink, JH , Vitart, V , Volker, U , Vuoksimaa, E , Wakil, SM , Waldenberger, M , Wander, GS , Wang, YX , Wareham, NJ , Wild, S , Yajnik, CS , Yuan, J-M , Zeng, L , Zhang, L , Zhou, J , Amin, N , Asselbergs, FW , Bakker, SJL , Becker, DM , Lehne, B , Bennett, DA , van den Berg, LH , Berndt, SI , Bharadwaj, D , Bielak, LF , Bochud, M , Boehnke, M , Bouchard, C , Bradfield, JP , Brody, JA , Campbell, A , Carmi, S , Caulfield, MJ , Cesarini, D , Chambers, JC , Chandak, GR , Cheng, C-Y , Ciullo, M , Cornelis, M , Cusi, D , Smith, GD , Deary, IJ , Dorajoo, R , van Duijn, CM , Ellinghaus, D , Erdmann, J , Eriksson, JG , Evangelou, E , Evans, MK , Faul, JD , Feenstra, B , Feitosa, M , Foisy, S , Franke, A , Friedlander, Y , Gasparini, P , Gieger, C , Gonzalez, C , Goyette, P , Grant, SFA , Griffiths, LR , Groop, L , Gudnason, V , Gyllensten, U , Hakonarson, H , Hamsten, A , van der Harst, P , Heng, C-K , Hicks, AA , Hochner, H , Huikuri, H , Hunt, SC , Jaddoe, VWV , De Jager, PL , Johannesson, M , Johansson, A , Jonas, JB , Jukema, JW , Junttila, J , Kaprio, J , Kardia, SLR , Karpe, F , Kumari, M , Laakso, M , van der Laan, SW , Lahti, J , Laudes, M , Lea, RA , Lieb, W , Lumley, T , Martin, NG , Marz, W , Matullo, G , McCarthy, MI , Medland, SE , Merriman, TR , Metspalu, A , Meyer, BF , Mohlke, KL , Montgomery, GW , Mook-Kanamori, D , Munroe, PB , North, KE , Nyholt, DR , O'connell, JR , Ober, C , Oldehinkel, AJ , Palmas, W , Palmer, C , Pasterkamp, GG , Patin, E , Pennell, CE , Perusse, L , Peyser, PA , Pirastu, M , Polderman, TJC , Porteous, DJ , Posthuma, D , Psaty, BM , Rioux, JD , Rivadeneira, F , Rotimi, C , Rotter, JI , Rudan, I , Den Ruijter, HM , Sanghera, DK , Sattar, N , Schmidt, R , Schulze, MB , Schunkert, H , Scott, RA , Shuldiner, AR , Sim, X , Small, N , Smith, JA , Sotoodehnia, N , Tai, E-S , Teumer, A , Timpson, NJ , Toniolo, D , Tregouet, D-A , Tuomi, T , Vollenweider, P , Wang, CA , Weir, DR , Whitfield, JB , Wijmenga, C , Wong, T-Y , Wright, J , Yang, J , Yu, L , Zemel, BS , Zonderman, AB , Perola, M , Magnusson, PKE , Uitterlinden, AG , Kooner, JS , Chasman, DI , Loos, RJF , Franceschini, N , Franke, L , Haley, CS , Hayward, C , Walters, RG , Perry, JRB , Esko, T , Helgason, A , Stefansson, K , Joshi, PK , Kubo, M , Wilson, JF , Okada, Yukinori , Deelen, Patrick , Wang, Carol A. , Pennell, Craig E. , Orozco, Lorena , Rohde, Rebecca , Schurmann, Claudia , Guo, Xiuqing , Giulianini, Franco , Zhang, Weihua , Medina-Gomez, Carolina , Karlsson, Robert , Bao, Yanchun , Bartz, Traci M. , Moore, Kristjan H. S. , Baumbach, Clemens , Biino, G , Bixley, MJ , Brumat, M , Chai, J-F , Corre, T , Cousminer, DL , Dekker, AM , Eccles, DA , Van Eijk, KR , Mason, Dan , Fuchsberger, C , Gao, H , Germain, M , Gordon, SD , de Haan, HG , Harris, SE , Hofer, E , Huerta-Chagoya, A , Igartua, C , Jansen, IE , Pirastu, Nicola , Jia, Y , Kacprowski, T , Karlsson, T , Kleber, ME , Li, SA , Li-Gao, R , Mahajan, A , Matsuda, K , Meidtner, K , Meng, W , Gandin, Ilaria , Montasser, ME , van der Most, PJ , Munz, M , Nutile, T , Palviainen, T , Prasad, G , Prasad, RB , Priyanka, TDS , Rizzi, F , Salvi, E , Mattsson, Hannele , Sapkota, BR , Shriner, D , Skotte, L , Smart, MC , Smith, AV , van der Spek, A , Spracklen, CN , Strawbridge, RJ , Tajuddin, SM , Trompet, S , Barnes, Catriona L. K. , Turman, C , Verweij, N , Viberti, C , Wang, L , Warren, HR , Wootton, RE , Yanek, LR , Yao, J , Yousri, NA , Zhao, W , Lin, Kuang , Adeyemo, AA , Afaq, S , Alberto Aguilar-Salinas, C , Akiyama, M , Albert, ML , Allison, MA , Alver, M , Aung, T , Azizi, F , Bentley, AR , Zhao, Jing Hua , Boeing, H , Boerwinkle, E , Borja, JB , de Borst, GJ , Bottinger, EP , Broer, L , Campbell, H , Chanock, S , Chee, M-L , Chen, G
- Resource Type: journal article
- Date: 2019
Dairy intake and body composition and cardiometabolic traits among adults: mendelian randomization analysis of 182041 individuals from 18 studies
- Creator: Huang, Tao , Sun, Dianjianyi , Graff, Mariaelisa , Smith, Caren E. , Varbo, Anette , Lemaitre, Rozenn N. , Corella, Dolores , Wang, Carol A. , Tjønneland, Anne , Overvad, Kim , Sørensen, Thorkild I. A. , Feitosa, Mary F. , Heianza, Yoriko , Wojczynski, Mary K. , Kähönen, M , Mikkilä, V , Bartz, TM , Psaty, BM , Siscovick, DS , Danning, RD , Dedoussis, G , Pedersen, O , Hansen, T , Bergholdt, Helle K. M. , Havulinna, AS , Männistö, S , Rotter, JI , Sares-Jäske, L , Allison, MA , Rich, SS , Sorlí, JV , Coltell, O , Pennell, CE , Eastwood, P , Gao, Meng , Ridker, PM , Viikari, J , Raitakari, O , Lehtimäki, T , Helminen, M , Wang, Y , Deloukas, P , Knekt, P , Kanerva, N , Kilpeläinen, TO , Fang, Zhe , Province, MA , Mozaffarian, D , Chasman, DI , Nordestgaard, BG , Ellervik, C , Qi, L , Ding, Ming , Frazier-Wood, Alexis C. , North, Kari E. , Marouli, Eirini
- Resource Type: journal article
- Date: 2019
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
- Creator: Merino, Jordi , Dashti, Hassan S. , Wojczynski, Mary K. , Männistö, Satu , Ngwa, Julius S. , Kho, Minjung , Ahluwalia, Tarunveer , Pervjakova, Natalia , Houston, Denise K. , Bouchard, Claude , Huang, Tao , Orho-Melander, Marju , Li, Sherly X. , Pennell, Craig E. , Wang, Carol A. , Pérusse, L , Pennell, CE , de Vries, PS , Voortman, T , Li, O , Kanoni, S , Rose, LM , Lehtimäki, T , Sarnowski, Chloé , Zhao, JH , Feitosa, MF , Luan, J , McKeown, NM , Smith, JA , Hansen, T , Eklund, N , Nalls, MA , Rankinen, T , Huang, J , Justice, Anne E. , Hernandez, DG , Schulz, CA , Manichaikul, A , Li-Gao, R , Vohl, MC , Wang, CA , van Rooij, FJA , Shin, J , Kalafati, IP , Day, F , Graff, Misa , Ridker, PM , Kähönen, M , Siscovick, DS , Langenberg, C , Zhao, W , Astrup, A , Knekt, P , Garcia, M , Rao, DC , Qi, Q , Papoutsakis, Constantina , Ferrucci, L , Ericson, U , Blangero, J , Hofman, A , Pausova, Z , Mikkilä, V , Wareham, NJ , Kardia, SLR , Pedersen, O , Jula, A , Smith, Caren E. , Curran, JE , Zillikens, MC , Viikari, JS , Forouhi, NG , Ordovás, JM , Lieske, JC , Rissanen, H , Uitterlinden, AG , Raitakari, OT , Kiefte-de Jong, JC , Dedoussis, George V. , Dupuis, J , Rotter, JI , North, KE , Scott, RA , Province, MA , Perola, M , Cupples, LA , Turner, ST , Sørensen, TIA , Salomaa, V , Lemaitre, Rozenn N. , Liu, Y , Sung, YJ , Qi, L , Bandinelli, S , Rich, SS , de Mutsert, R , Tremblay, A , Oddy, WH , Franco, OH , Paus, T
- Resource Type: journal article
- Date: 2019
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
- Creator: Davies, Gail , Lam, Max , Liewald, David C. M. , Knopman, DS , Kochan, NA , Konte, B , Kwok, JB , Le Hellard, S , Lee, T , Lehtimaki, T , Li, S-C , Liu, T , Koini, M , Okely, Judith A. , London, E , Longstreth, WT , Lopez, OL , Loukola, A , Luck, T , Lundervold, AJ , Lundquist, A , Lyytikainen, L-P , Martin, NG , Montgomery, GW , Ahola-Olli, Ari V. , Murray, AD , Need, AC , Noordam, R , Nyberg, L , Ollier, W , Papenberg, G , Pattie, A , Polasek, O , Poldrack, RA , Psaty, BM , Barnes, Catriona L. K. , Reppermund, S , Riedel-Heller, SG , Rose, RJ , Rotter, JI , Roussos, P , Rovio, SP , Saba, Y. , Sabb, FW , Sachdev, PS , Satizabal, CL , Bertram, Lars , Schmid, M , Scott, Rodney J. , Scult, MA , Simino, J , Slagboom, PE , Smyrnis, N , Soumare, A , Stefanis, NC , Stott, DJ , Straub, RE , Bis, Joshua C. , Sundet, K , Taylor, AM , Taylor, KD , Tzoulaki, I , Tzourio, C , Uitterlinden, A , Vitart, V , Voineskos, AN , Kaprio, J , Wagner, M , Burdick, Katherine E. , Wagner, H , Weinhold, L , Wen, KH , Widen, E , Yang, Q , Zhao, W , Adams, HHH , Arking, DE , Bilder, RM , Bitsios, P , Christoforou, Andrea , Boerwinkle, E , Chiba-Falek, O , Corvin, A , De Jager, PL , Debette, S , Donohoe, G , Elliott, P , Fitzpatrick, AL , Gill, M , Glahn, DC , DeRosse, Pamela , Hagg, S , Hansell, NK , Hariri, AR , Ikram, MK , Jukema, JW , Vuoksimaa, E , Keller, MC , Kremen, WS , Launer, L , Lindenberger, U , Djurovic, Srdjan , Palotie, A , Pedersen, NL , Pendleton, N , Porteous, DJ , Raikkonen, K , Raitakari, OT , Ramirez, A , Reinvang, I , Rudan, I , Rujescu, D , Harris, Sarah E. , Espeseth, Thomas , Schmidt, R , Schmidt, H , Schofield, PW , Schofield, PR , Starr, JM , Steen, VM , Trollor, JN , Turner, ST , Van Duijn, CM , Villringer, A , Giakoumaki, Stella , Weinberger, DR , Weir, DR , Wilson, JF , Malhotra, A , McIntosh, AM , Gale, CR , Seshadri, S , Mosley, TH , Bressler, J , Lencz, T , Giddaluru, S , Deary, IJ , Gustavson, DE , Hayward, C , Hofer, E , Ikram, MA , Karlsson, R , Knowles, E , Lahti, J , Trampush, Joey W. , Leber, M , Li, S , Mather, KA , Melle, I , Morris, D , Oldmeadow, Christopher , Palviainen, T , Payton, A , Pazoki, R , Petrovic, K , Luciano, Michelle , Reynolds, CA , Sargurupremraj, M , Scholz, M , Smith, JA , Smith, AV , Terzikhan, N , Thalamuthu, A , Trompet, S , van der Lee, SJ , Ware, EB , Hill, W. David , Windham, BG , Wright, MJ , Yang, J , Yu, J , Ames, D , Amin, N , Amouyel, P , Andreassen, OA , Armstrong, NJ , Assareh, AA , Hagenaars, Saskia P. , Attia, John R. , Attix, D , Avramopoulos, D , Bennett, DA , Boehmer, AC , Boyle, PA , Brodaty, H , Campbell, H , Cannon, TD , Cirulli, ET , Ritchie, Stuart J. , Congdon, E , Conley, ED , Corley, J , Cox, SR , Dale, AM , Dehghan, A , Dick, D , Dickinson, D , Eriksson, JG , Evangelou, E , Marioni, Riccardo E. , Faul, JD , Ford, I , Freimer, NA , Gao, H , Giegling, I , Gillespie, NA , Gordon, SD , Gottesman, RF , Griswold, ME , Gudnason, V , Fawns-Ritchie, Chloe , Harris, TB , Hartmann, AM , Hatzimanolis, A , Heiss, G , Holliday, Elizabeth G. , Joshi, PK , Kahonen, M , Kardia, SLR , Karlsson, I , Kleineidam, L
- Resource Type: journal article
- Date: 2018