PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
- Creator: Duchatel, Ryan J. , Jackson, Evangeline R. , Kearney, Padraic S. , Jamaluddin, M. Fairuz B. , Douglas, Alicia M. , Beitaki, Tyrone , McEwen, Holly P. , Persson, Mika L. , Hocke, Emily A. , Jain, Vaibhav , Aksu, Michael , Manning, Elizabeth E. , Parackal, Sarah G. , Murray, Heather C. , Verrills, Nicole M. , Hua, Susan , Cairns, Murray J. , Alvaro, Frank , Dayas, Christopher V. , Dun, Matthew D. , Hua, S , de Bock, CE , Colino-Sanguino, Y , Kiltschewskij, Dylan , Valdes-Mora, F , Tsoli, M , Ziegler, DS , Cairns, MJ , Raabe, EH , Vitanza, NA , Hulleman, E , Phoenix, TN , Koschmann, C , Alvaro, F , Findlay, Izac J. , Dayas, CV , Tinkle, CL , Wheeler, H , Whittle, JR , Eisenstat, DD , Firestein, R , Mueller, S , Valvi, S , Hansford, JR , Ashley, DM , Mannan, Abdul , Gregory, SG , Kilburn, LB , Nazarian, J , Cain, JE , Dun, MD , Staudt, Dilana E. , Thomas, Bryce C. , Germon, Zacary P. , Laternser, Sandra
- Resource Type: journal article
- Date: 2024
ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
- Creator: Jackson, Evangeline R. , Duchatel, Ryan J. , Le Grand, Marion , Kearney, Padraic S. , Douglas, Alicia M. , Findlay, Izac J. , Germon, Zacary P. , McEwen, Holly P. , Beitaki, Tyrone S. , Patabendige, Adjanie , Skerrett-Byrne, David A. , Nixon, Brett , Staudt, Dilana E. , Smith, Nathan D. , Day, B , Manoharan, N , Nagabushan, S , Hansford, JR , Govender, D , McCowage, GB , Firestein, R , Howlett, M , Endersby, R , Persson, Mika L. , Gottardo, NG , Alvaro, F , Waszak, SM , Larsen, MR , Colino-Sanguino, Y , Valdés-Mora, F , Rakotomalala, A , Meignan, S , Pasquier, E , Andre, N , Mannan, Abdul , Hulleman, E , Eisenstat, DD , Vitanza, NA , Nazarian, J , Koschmann, C , Mueller, S , Cain, JE , Dun, MD , Yadavilli, Sridevi , Parackal, Sarah , Game, Shaye , Chong, Wai Chin , Jayasekara, W. Samantha N.
- Resource Type: journal article
- Date: 2023
PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
- Creator: Alhalabi, Karam T. , Stichel, Damian , Pajtler, Kristian W. , Snuderl, Matija , Jour, George , Delorenzo, Michael , Martin, Allison M. , Levy, Adam , Dalvi, Nagma , Hansford, Jordan R. , Gottardo, Nicholas G. , Uro-Coste, Emmanuelle , Sievers, Philipp , Alvaro, Frank , Godfraind, C , Vandenbos, F , Pietsch, T , Kramm, C , Filippidou, M , Kattamis, A , Jones, C , Ora, I , Mikkelsen, TS , Peterziel, Heike , Zapotocky, M , Sumerauer, D , Scheie, D , McCabe, M , Wesseling, P , Tops, BBJ , Kranendonk, MEG , Karajannis, MA , Bouvier, N , Papaemmanuil, E , Sommerkamp, Alexander C. , Dohmen, H , Acker, T , von Hoff, K , Schmid, S , Miele, E , Filipski, K , Kitanovski, L , Krskova, L , Gojo, J , Haberler, C , Sturm, Dominik , Alvaro, F , Ecker, J , Selt, F , Milde, T , Witt, O , Oehme, I , Kool, M , von Deimling, A , Korshunov, A , Pfister, SM , Wittmann, Andrea , Sahm, F , Jones, DTW , Sill, Martin , Jäger, Natalie , Beck, Pengbo
- Resource Type: journal article
- Date: 2021
Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia
- Creator: Dun, Matthew D. , Mannan, Abdul , Germon, Zacary , Faulkner, Sam , Chi, Mengna , Skerrett-Byrne, David , Murray, Heather C. , Flanagan, Hayley , Almazi, Juhura G. , Hondermarck, Hubert , Nixon, Brett , De Iuliis, Geoff , Rigby, Callum J. , Chamberlain, J , Alvaro, F , de Bock, CE , Morris, JC , Enjeti, Anoop K. , Verrills, Nicole M. , Butler, Stephen , Toop, Hamish D. , Beck, Dominik , Connerty, Patrick , Sillar, Jonathan , Kahl, Richard G. S. , Duchatel, Ryan J.
- Resource Type: journal article
- Date: 2020