A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice

- Darbey, Annalcuia, Rebourcet, Diane, Curley, Michael, Kilcoyne, Karen, Jeffery, Nathan, Reed, Natalie, Milne, Laura, Roesl, Cornelia, Brown, Pamela, Smith, Lee B.

A graphical and computational modeling platform for biological pathways

- Livigni, Alessandra, O'Hara, Laura, Polak, Marta E., Angus, Tim, Wright, Derek W., Smith, Lee B., Freeman, Tom C.

A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

- Gannon, Anne-Louise, Darbey, Annalucia L., Rebourcet, Diane, Chensee, Grace, Lawrence, Ben M., O'Donnell, Liza, Kelso, Joanna, Reed, Natalie, Parameswaran, Shanmathi, Smith, Sarah, Smith, Lee B.

A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

- Curley, Michael, Milne, Laura, Smith, Sarah, Jørgensen, Anne, Frederiksen, Hanne, Hadoke, Patrick, Potter, Paul, Smith, Lee B.

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

- Gannon, Anne-Louise, O'Hara, Laura, Mitchell, Rod T., Smith, Lee B., Mason, J. Ian, Rebourcet, Diane, Smith, Sarah, Traveres, Adriana, Alcaide-Corral, Carlos Jose, Frederiksen, Hanne, Jorgensen, Anne, Milne, Laura

Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production

- Rebourcet, Diane, Mackay, Rosa, Darbey, Annalucia, Curley, Michael K., Jørgensen, Anne, Frederiksen, Hanne, Mitchell, Rod T., O'Shaughnessy, Peter J., Nef, Serge, Smith, Lee B.

Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis

- O'Shaughnessy, Peter J., Mitchell, Rod T., Monteiro, Ana, O'Hara, Laura, Cruickshanks, Lyndsey, Claahsen-van der Grinten, Hedi, Brown, Pamela, Abel, Margaret, Smith, Lee B.

Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity

- Gannon, Anne-Louise, O'Hara, Laura, Mason, Ian J., Jørgensen, Anne, Frederiksen, Hanne, Curley, Michael, Milne, Laura, Smith, Sarah, Mitchell, Rod T., Smith, Lee B.

Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing

- Gannon, Anne-Louise, O'Hara, Laura, Mason, J. Ian, Jørgensen, Anne, Frederiksen, Hanne, Milne, Laura, Smith, Sarah, Mitchell, Rod T., Smith, Lee B.

Bi-allelic recessive loss-of-function variants in FANCM cause non-obstructive azoospermia

- Kasak, Laura, Punab, Margus, Smith, Lee B., Conrad, Donald F., Laan, Maris, Nagirnaja, Liina, Grigorova, Marina, Minajeva, Ave, Lopes, Alexandra M., Punab, Anna Maria, Aston, Kenneth I., Carvalho, Filipa, Laasik, Eve

Characterisation of a mural cell network in the murine pituitary gland

- O'Hara, Laura, Christian, Helen C., Jeffery, Nathan, Le Tissier, Paul, Smith, Lee B.

Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing

- Stévant, Isabelle, Neirijnck, Yasmine, Borel, Christelle, Escoffier, Jessica, Smith, Lee B., Antonarakis, Stylianos E., Dermitzakis, Emmanouil T., Nef, Serge

Deliverable transgenics & gene therapy possibilities for the testes

- Darbey, Annalucia, Smith, Lee B.

DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

- Macdonald, Joni, Kilcoyne, Karen R., Sharpe, Richard M., Kavanagh, Áine, Anderson, Richard A., Brown, Pamela, Smith, Lee B., Jørgensen, Anne, Mitchell, Rod T.

Exogenous gonadotrophin stimulation induces partial maturation of human sertoli cells in a testicular xenotransplantation model for fertility preservation

- Hutka, Marsida, Smith, Lee B., Goossens, Ellen, Wallace, W. Hamish B., Stukenborg, Jan-Bernd, Mitchell, Rod T.

Fertility preservation in childhood cancer: endocrine activity in prepubertal human testis xenografts exposed to a pubertal hormone environment

- Hutka, Marsida, Kadam, Prashant, Van Saen, Dorien, Homer, Natalie Z. M., Onofre, Jaime, Wallace, W. Hamish B., Smith, Lee B., Stukenborg, Jan-Bernd, Goossens, Ellen, Mitchell, Rod T.

Human Adipose-derived pericytes display steroidogenic lineage potential in vitro and influence Leydig cell regeneration in vivo in rats

- Curley, Michael, Gonzalez, Zaniah N., Milne, Laura, Hadoke, Patrick, Handel, Ian, Péault, Bruno, Smith, Lee B.

Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female-like lactotroph development

- O'Hara, Laura, Christian, Helen C., Le Tissier, Paul, Smith, Lee B.

Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells

- Neirijnck, Yasmine, Calvel, Pierre, Smith, Lee B., Nef, Serge, Kilcoyne, Karen R., Kühne, Françoise, Stévant, Isbelle, Griffeth, Richard J., Pitetti, Jean-Lüc, Andric, Silvana A., Hu, Meng-Chun, Pralong, François

Leukemia inhibitory factor-receptor is dispensable for prenatal testis development but is required in sertoli cells for normal spermatogenesis in mice

- Curley, Michael, Milne, Laura, Smith, Sarah, Atanassova, Nina, Rebourcet, Diane, Darbey, Annalucia, Hadoke, Patrick W. F., Wells, Sara, Smith, Lee B.