A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice
- Darbey, Annalcuia, Rebourcet, Diane, Curley, Michael, Kilcoyne, Karen, Jeffery, Nathan, Reed, Natalie, Milne, Laura, Roesl, Cornelia, Brown, Pamela, Smith, Lee B.
- Creator: Darbey, Annalcuia , Rebourcet, Diane , Curley, Michael , Kilcoyne, Karen , Jeffery, Nathan , Reed, Natalie , Milne, Laura , Roesl, Cornelia , Brown, Pamela , Smith, Lee B.
- Resource Type: journal article
- Date: 2020
- Creator: Darbey, Annalcuia , Rebourcet, Diane , Curley, Michael , Kilcoyne, Karen , Jeffery, Nathan , Reed, Natalie , Milne, Laura , Roesl, Cornelia , Brown, Pamela , Smith, Lee B.
- Resource Type: journal article
- Date: 2020
A graphical and computational modeling platform for biological pathways
- Livigni, Alessandra, O'Hara, Laura, Polak, Marta E., Angus, Tim, Wright, Derek W., Smith, Lee B., Freeman, Tom C.
- Creator: Livigni, Alessandra , O'Hara, Laura , Polak, Marta E. , Angus, Tim , Wright, Derek W. , Smith, Lee B. , Freeman, Tom C.
- Resource Type: journal article
- Date: 2018
Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis
- O'Shaughnessy, Peter J., Mitchell, Rod T., Monteiro, Ana, O'Hara, Laura, Cruickshanks, Lyndsey, Claahsen-van der Grinten, Hedi, Brown, Pamela, Abel, Margaret, Smith, Lee B.
- Creator: O'Shaughnessy, Peter J. , Mitchell, Rod T. , Monteiro, Ana , O'Hara, Laura , Cruickshanks, Lyndsey , Claahsen-van der Grinten, Hedi , Brown, Pamela , Abel, Margaret , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
- Creator: O'Shaughnessy, Peter J. , Mitchell, Rod T. , Monteiro, Ana , O'Hara, Laura , Cruickshanks, Lyndsey , Claahsen-van der Grinten, Hedi , Brown, Pamela , Abel, Margaret , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing
- Gannon, Anne-Louise, O'Hara, Laura, Mason, J. Ian, Jørgensen, Anne, Frederiksen, Hanne, Milne, Laura, Smith, Sarah, Mitchell, Rod T., Smith, Lee B.
- Creator: Gannon, Anne-Louise , O'Hara, Laura , Mason, J. Ian , Jørgensen, Anne , Frederiksen, Hanne , Milne, Laura , Smith, Sarah , Mitchell, Rod T. , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
- Creator: Gannon, Anne-Louise , O'Hara, Laura , Mason, J. Ian , Jørgensen, Anne , Frederiksen, Hanne , Milne, Laura , Smith, Sarah , Mitchell, Rod T. , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
Bi-allelic recessive loss-of-function variants in FANCM cause non-obstructive azoospermia
- Kasak, Laura, Punab, Margus, Smith, Lee B., Conrad, Donald F., Laan, Maris, Nagirnaja, Liina, Grigorova, Marina, Minajeva, Ave, Lopes, Alexandra M., Punab, Anna Maria, Aston, Kenneth I., Carvalho, Filipa, Laasik, Eve
- Creator: Kasak, Laura , Punab, Margus , Smith, Lee B. , Conrad, Donald F. , Laan, Maris , Nagirnaja, Liina , Grigorova, Marina , Minajeva, Ave , Lopes, Alexandra M. , Punab, Anna Maria , Aston, Kenneth I. , Carvalho, Filipa , Laasik, Eve
- Resource Type: journal article
- Date: 2018
Characterisation of a mural cell network in the murine pituitary gland
- O'Hara, Laura, Christian, Helen C., Jeffery, Nathan, Le Tissier, Paul, Smith, Lee B.
- Creator: O'Hara, Laura , Christian, Helen C. , Jeffery, Nathan , Le Tissier, Paul , Smith, Lee B.
- Resource Type: journal article
- Date: 2020
- Creator: O'Hara, Laura , Christian, Helen C. , Jeffery, Nathan , Le Tissier, Paul , Smith, Lee B.
- Resource Type: journal article
- Date: 2020
Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing
- Stévant, Isabelle, Neirijnck, Yasmine, Borel, Christelle, Escoffier, Jessica, Smith, Lee B., Antonarakis, Stylianos E., Dermitzakis, Emmanouil T., Nef, Serge
- Creator: Stévant, Isabelle , Neirijnck, Yasmine , Borel, Christelle , Escoffier, Jessica , Smith, Lee B. , Antonarakis, Stylianos E. , Dermitzakis, Emmanouil T. , Nef, Serge
- Resource Type: journal article
- Date: 2018
Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing
- Creator: Stévant, Isabelle , Neirijnck, Yasmine , Borel, Christelle , Escoffier, Jessica , Smith, Lee B. , Antonarakis, Stylianos E. , Dermitzakis, Emmanouil T. , Nef, Serge
- Resource Type: journal article
- Date: 2018
DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads
- Macdonald, Joni, Kilcoyne, Karen R., Sharpe, Richard M., Kavanagh, Áine, Anderson, Richard A., Brown, Pamela, Smith, Lee B., Jørgensen, Anne, Mitchell, Rod T.
- Creator: Macdonald, Joni , Kilcoyne, Karen R. , Sharpe, Richard M. , Kavanagh, Áine , Anderson, Richard A. , Brown, Pamela , Smith, Lee B. , Jørgensen, Anne , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2018
- Creator: Macdonald, Joni , Kilcoyne, Karen R. , Sharpe, Richard M. , Kavanagh, Áine , Anderson, Richard A. , Brown, Pamela , Smith, Lee B. , Jørgensen, Anne , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2018
Leukemia inhibitory factor-receptor is dispensable for prenatal testis development but is required in sertoli cells for normal spermatogenesis in mice
- Curley, Michael, Milne, Laura, Smith, Sarah, Atanassova, Nina, Rebourcet, Diane, Darbey, Annalucia, Hadoke, Patrick W. F., Wells, Sara, Smith, Lee B.
- Creator: Curley, Michael , Milne, Laura , Smith, Sarah , Atanassova, Nina , Rebourcet, Diane , Darbey, Annalucia , Hadoke, Patrick W. F. , Wells, Sara , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
- Creator: Curley, Michael , Milne, Laura , Smith, Sarah , Atanassova, Nina , Rebourcet, Diane , Darbey, Annalucia , Hadoke, Patrick W. F. , Wells, Sara , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics
- Patel, Saloni H., O'Hara, Laura, Atanassova, Nina, Smith, Sarah E., Curley, Michael K., Rebourcet, Diane, Darbey, Annalucia L., Gannon, Anne-Louise, Sharpe, Richard M., Smith, Lee B.
- Creator: Patel, Saloni H. , O'Hara, Laura , Atanassova, Nina , Smith, Sarah E. , Curley, Michael K. , Rebourcet, Diane , Darbey, Annalucia L. , Gannon, Anne-Louise , Sharpe, Richard M. , Smith, Lee B.
- Resource Type: journal article
- Date: 2017
- Creator: Patel, Saloni H. , O'Hara, Laura , Atanassova, Nina , Smith, Sarah E. , Curley, Michael K. , Rebourcet, Diane , Darbey, Annalucia L. , Gannon, Anne-Louise , Sharpe, Richard M. , Smith, Lee B.
- Resource Type: journal article
- Date: 2017
Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies
- O'Hara, Laura, O'Shaughnessy, Peter J., Freeman, Tom C., Smith, Lee B.
- Creator: O'Hara, Laura , O'Shaughnessy, Peter J. , Freeman, Tom C. , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
- Creator: O'Hara, Laura , O'Shaughnessy, Peter J. , Freeman, Tom C. , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus
- Pridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J., Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B.
- Creator: Pridans, Clare , Raper, Anna , Davis, Gemma M. , Alves, Joana , Sauter, Kristin A. , Lefevre, Lucas , Regan, Tim , Meek, Stephen , Sutherland, Linda , Thomson, Alison J. , Clohisey, Sara , Bush, Stephen J. , Rojo, Rocío , Lisowski, Zofia M. , Wallace, Robert , Grabert, Kathleen , Upton, Kyle R. , Tsai, Yi Ting , Brown, Deborah , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
- Creator: Pridans, Clare , Raper, Anna , Davis, Gemma M. , Alves, Joana , Sauter, Kristin A. , Lefevre, Lucas , Regan, Tim , Meek, Stephen , Sutherland, Linda , Thomson, Alison J. , Clohisey, Sara , Bush, Stephen J. , Rojo, Rocío , Lisowski, Zofia M. , Wallace, Robert , Grabert, Kathleen , Upton, Kyle R. , Tsai, Yi Ting , Brown, Deborah , Smith, Lee B.
- Resource Type: journal article
- Date: 2018
Reconstitution of rat fetal testis during the masculinisation programming window induces focal dysgenesis consistent with testicular dysgenesis syndrome
- Smart, Ellie, Macdonald, Joni, Smith, Lee B., Mitchell, Rod T.
- Creator: Smart, Ellie , Macdonald, Joni , Smith, Lee B. , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2020
- Creator: Smart, Ellie , Macdonald, Joni , Smith, Lee B. , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2020
Sertoli cell number defines and predicts germ and Leydig cell population sizes in the adult mouse testis
- Rebourcet, Diane, Darbey, Annalucia, Monteiro, Ana, Soffientini, Ugo, Tsai, Yi Ting, Handel, Ian, Pitetti, Jean-Luc, Nef, Serge, Smith, Lee B., O'Shaughnessy, Peter J.
- Creator: Rebourcet, Diane , Darbey, Annalucia , Monteiro, Ana , Soffientini, Ugo , Tsai, Yi Ting , Handel, Ian , Pitetti, Jean-Luc , Nef, Serge , Smith, Lee B. , O'Shaughnessy, Peter J.
- Resource Type: journal article
- Date: 2017
- Creator: Rebourcet, Diane , Darbey, Annalucia , Monteiro, Ana , Soffientini, Ugo , Tsai, Yi Ting , Handel, Ian , Pitetti, Jean-Luc , Nef, Serge , Smith, Lee B. , O'Shaughnessy, Peter J.
- Resource Type: journal article
- Date: 2017
The expanded roles of Sertoli cells: lessons from Sertoli cell ablation models
- Rebourcet, Diane, O'Shaughnessy, Peter J., Smith, Lee B.
- Creator: Rebourcet, Diane , O'Shaughnessy, Peter J. , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
- Creator: Rebourcet, Diane , O'Shaughnessy, Peter J. , Smith, Lee B.
- Resource Type: journal article
- Date: 2019
Xenotransplantation as a model for human testicular development
- Hutka, Marsida, Smith, Lee B., Mitchell, Rod T.
- Creator: Hutka, Marsida , Smith, Lee B. , Mitchell, Rod T.
- Resource Type: journal article
- Date: 2017
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