17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

- Adib-Samii, Poneh, Rost, Natalia, Gschwendtner, Andreas, Malik, Rainer, Richie, Alexa, Gamble, Dale, Segal, Helen, Parati, Eugenio A., Ciusani, Emilio, Holliday, Elizabeth G., Maguire, Jane, Wardlaw, Joanna, Traylor, Matthew, Worrall, Bradford, Bis, Joshua, Wiggins, Kerri L., Longstreth, Will, Kittner, Steve J., Cheng, Yu-Ching, Mosley, Thomas, Falcone, Guido J., Furie, Karen L., Leiva-Salinas, Carlos, Devan, William, Lau, Benison C., Saleem Khan, Muhammed, Australian Stroke Genetics Collaborative, Wellcome Trust Case-Control Consortium-2, METASTROKE, Sharma, Pankaj, Fornage, Miriam, Mitchell, Braxton D., Psaty, Bruce M., Sudlow, Cathie, Biffi, Alessandro, Levi, Christopher, Boncoraglio, Giorgio B., Rothwell, Peter M., Meschia, James, Dichgans, Martin, Rosand, Jonathan, Markus, Hugh S., Lanfranconi, Silvia, Fitzpatrick, Kaitlin, Bevan, Steve, Kanakis, Allison, Valant, Valerie

A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

- Traylor, Matthew, Mäkelä, Kari-Matti, Malik, Rainer, Sudlow, Cathie, Bevan, Steve, Raitoharju, Emma, Oksala, Niku, Thijs, Vincent, Lemmens, Robin, Lindgren, Arne, Slowik, Agnieszka, Kilarski, Laura L., Maguire, Jane M., Walters, Matthew, Algra, Ale, Sharma, Pankaj, Attia, John R., Boncoraglio, Giorgio B., Rothwell, Peter M., de Bakker, Paul I. W., Bis, Joshua C., Saleheen, Danish, Holliday, ELizabeth G., Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Meschia, James F., Levi, Christopher, Dichgans, Martin, Lehtimäki, Terho, Lewis, Cathryn M., Markus, Hugh S., Devan, William J., Nalls, Mike A., Wiggins, Kerri L., Zhao, Wei, Cheng, Yu-Ching, Achterberg, Sefanja

Analysis of shared heritability in common disorders of the brain

- Anttila, Verneri, Bulik-Sullivan, Brendan, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Finucane, Hilary K., Holliday, Elizabeth, Attia, John, Cairns, Murray, Loughland, Carmel, Schall, Ulrich, Henskens, Frans, Scott, Rodney, Reitz, C, Goate, AM, Huentelman, MJ, Walters, Raymond K., Ilyas Kamboh, M, Larson, EB, Rogaeva, E, George-Hyslop, PS, Hakonarson, H, Kukull, WA, Farrer, LA, Barnes, LL, Beach, TG, Yesim Demirci, F, Bras, Jose, Head, E, Hulette, CM, Jicha, GA, Kauwe, JSK, Kaye, JA, Leverenz, JB, Levey, AI, Lieberman, AP, Pankratz, VS, Poon, WW, Duncan, Laramie, Quinn, JF, Saykin, AJ, Schneider, LS, Smith, AG, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer

Common coding variant in SERPINA1 increases the risk for large artery stroke

- Malik, Rainer, Cardenas, IF, Rothwell, PM, Levi, C, Attia, J, Sudlow, CLM, Braun, D, Markus, HS, Wintrode, PL, Berger, K, Jenne, DE, Dichgans, M, Dau, Therese, Seixas, Susana, Bevan, Steve, Lincz, Lisa F., Holliday, Elizabeth G., Burgess, Annette I., Rannikmäe, Kristiina, Minnerup, Jens, Kriebel, Jennifer, Waldenberger, Melanie, Müller-Nurasyid, Martina, Gonik, Maria, Levi, Christopher, Attia, John, Maguire, Jane, Sivakumar, Anirudh, Deredge, Daniel J., Edeleva, Evgeniia V., Götzfried, Jessica, van der Laan, Sander W., Pasterkamp, Gerard, Beaufort, Nathalie

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

- Holliday, Elizabeth G., Maguire, Jane M., Malik, Rainer, McEvoy, Mark, Biros, Erik, Lewis, Martin D., Lincz, Lisa F., Peel, Roseanne, Oldmeadow, Christopher, Smith, Wayne, Moscato, Pablo, Barlera, Simona, Evans, Tiffany-Jane, Bevan, Steve, Bis, Joshua C., Boerwinkle, Eric, Boncoraglio, Giorgio B., Brott, Thomas G., Scott, Rodney J., Levi, Christopher, Attia, John, Koblar, Simon A., Jannes, Jim, Sturm, Jonathan W., Hankey, Graeme J., Baker, Ross, Golledge, Jonathan, Parsons, Mark W.

Differences in common genetic predisposition to ischemic stroke by age and sex

- Traylor, Matthew, Rutten-Jacobs, Loes C. A., Dichgans, Martin, Levi, Chris, Lewis, Cathryn M., Markus, Hugh S., Holliday, Elizabeth G., Malik, Rainer, Sudlow, Cathie, Rothwell, Peter M., Maguire, Jane M., Koblar, Simon A., Bevan, Steve, Boncoraglio, Giorgio

Effect of genetic variants associated with plasma homocysteine levels on stroke risk

- Cotlarciuc, Iona, Malik, Rainer, Markus, Hugh S., Rosand, Jonathan, Mitchell, Braxton D., Kittner, Steven J., Meschia, James F., van Meurs, Joyce B. J., Uitterlinden, Andre G., Worrall, Bradford B., Dichgans, Martin, Sharma, Pankaj, Holliday, Elizabeth G., Ahmadi, Kourosh R., Paré, Guillaume, Psaty, Bruce M., Fornage, Myriam, Hasan, Nazeeha, Rinne, Paul E., Ikram, M. Arfan

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

- Chauhan, Ganesh, Adams, Hieab H. H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheung, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, G. D., Kjartansson, O., Guðnason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N, Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C.Y., Wong, T. Y., Ikram, M. K., van der Lee, S. J., Amin, N., Chouraki, V., Destefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., Decarli, C., Wardlaw, J. M., Del C. Valdés Hernández, M., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Maniega, S. M., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H. W., Lemmens, R., Brodaty, H., Wright, MJ., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., van der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., van der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., von Sarnowski, B., Völker, U., Levi, Christopher, Jimenez-Conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Mechia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Asselbergs, F. R., Srikanth, V., Thomson, R., McWhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-Jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T., Debette, S.

Genetic associations with white matter hyperintensities confer risk of lacunar stroke

- Traylor, Matthew, Rutten-Jacobs, Loes C. A., Dichgans, Martin, Markus, Hugh S., Thijs, Vincent, Holliday, Elizabeth G., Levi, Chris, Bevan, Steve, Malik, Rainer, Boncoraglio, Giorgio, Sudlow, Cathie, Rothwell, Peter M.

Genetic overlap between diagnostic subtypes of ischemic stroke

- Holliday, Elizabeth G., Traylor, Matthew, Boncoraglio, Giorgio B., Clarke, Robert, Cole, John W., Fornage, Myriam, Furie, Karen L., Ikram, M. Arfan, Jannes, Jim, Kittner, Steven J., Lincz, Lisa F., Maguire, Jane M., Malik, Rainer, Oldmeadow, Christopher, Scott, Rodney J., Levi, Christopher, Attia, John, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C., Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C., Boerwinkle, Eric

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

- Traylor, Matthew, Farrall, Martin, Thorsteinsdottir, Unnur, Nalls, Mike A., Longstreth, W. T., Wiggins, Kerri L., Yadav, Sunaina, Parati, Eugenio A., Destefano, Anita L., Worrall, Bradford B., Kittner, Steven J., Khan, Muhammad Saleem, Holliday, Elizabeth G., Reiner, Alex P., Helgadottir, Anna, Achterberg, Sefanja, Fernandez-Cadenas, Israel, Abboud, Sherine, Schmidt, Reinhold, Walters, Matthew, Chen, Wei-Min, Ringelstein, E. Bernd, O'Donnell, Martin, Sudlow, Cathie, Ho, Weang Kee, Pera, Joanna, Lemmens, Robin, Norrving, Bo, Higgins, Peter, Benn, Marianne, Sale, Michele, Kuhlenbaumer, Gregor, Doney, Alexander S. F., Vicente, Astrid M., Hopewell, Jemma C., Delavaran, Hossein, Algra, Ale, Davies, Gail, Oliveira, Sophia A., Palmer, Colin N. A., Deary, Ian, Schmidt, Helena, Pandolfo, Massimo, Montaner, Joan, Carty, Cara, Cheng, Yu-Ching, De Bakker, Paul I. W., Kostulas, Konstantinos, Ferro, Jose M., Van Zuydam, Natalie R., Valdimarsson, Einar, Nordestgaard, Berge G., Lindgren, Anne, Thijs, Vincent, Slowik, Agnieszka, Saleheen, Danish, Fornage, Myriam, Paré, Guillaume, Berger, Klaus, Thorleifsson, Gudmar, Astc, W., Hofman, Albert, Mosley, Thomas H., Mitchell, Branxton D., Furie, Karen, Clarke, Robert, Levi, Christopher, Arfan Ikram, M,, Seshadri, Sudha, Gschwendtner, Andreas, Boncoraglio, Giorgio B., Sharma, Pankaj, Bis, Joshua C., Gretarsdottir, Solveig, Psaty, Bruce M., Rothwell, Peter M., Rosand, Jonathan, Meschia, James F., Malik, Rainer, Stefansson, Kari, Dichgans, Martin, Markus, Hugh S., Bevan, Steve

Genetic variation at 16q24.2 is associated with small vessel stroke

- Traylor, Matthew, Malik, Rainer, Yet, Idil, Spector, Tim D., Bell, Jordana T., Hannon, Ellis, Mill, Jonathan, Chauhan, Ganesh, Debette, Stephanie, Bis, Joshua C., Longstreth, W. T., Ikram, M. Arfan, Nalls, Mike A., Levi, Chris, Cotlarciuc, Iona, Radmanesh, Farid, Thorleifsson, Gudmar, Hanscombe, Ken B., Langefeld, Carl, Saleheen, Danish, Rost, Natalia S.

Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

- Cole, John W., Xu, Huichun, Ryan, Kathleen, Jaworek, Thomas, Dueker, Nicole, McArdle, Patrick, Gaynor, Brady, Cheng, Yu-Ching, O'Connell, Jeffrey, Bevan, Steve, Malik, Rainer, Ahmed, Naveed Uddin, Amouyel, Philippe, Anjum, Sheraz, Bis, Joshua C., Crosslin, David, Danesh, John, Engelter, Stefan T., Fornage, Myriam, Frossard, Philippe, Holliday, Elizabeth, Levi, Christopher

Genome-wide analysis of blood pressure variability and ischemic stroke

- Yadav, Sunaina, Cotlarciuc, Ioana, Holliday, Elizabeth G., Speed, Douglas, Hasan, Nazeeha, Pucek, Mateusz, Rinne, Paul E., Sever, Peter, Stanton, Alice, Shields, Denis C., Maguire, Jane M., McEvoy, Mark, Munroe, Patricia B., Scott, Rodney J., Ferrucci, Luigi, Macleod, Mary J., Attia, John, Markus, Hugh S., Sale, Michele M., Worrall, Bradford B., Mitchell, Braxton D., Dichgans, Martin, Sudlow, Cathy, Khan, Muhammad S., Meschia, James F., Rothwell, Peter M., Caulfield, Mark, Sharma, Pankaj, International Stroke Genetics Consortium,, Nalls, Michael A., Bevan, Steve, Cheng, Yu-Ching, Chen, Wei-Min, Malik, Rainer, McCarthy, Nina S.

Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2

- Cheng, Yu-Ching, Stanne, Tara M., Cole, John W., O'Connell, Jeffrey R., Danesh, John, Rasheed, Asif, Zhao, Wei, Engelter, Stefan, Grond-Ginsbach, Caspar, Kamatani, Yoichiro, Lathrop, Mark, Leys, Didier, Giese, Anne-Katrin, Levi, Christopher, Ho, Weang Kee, Traylor, Matthew, Amouyel, Philippe, Holliday, Elizabeth G., Malik, Rainer, Xu, Huichun, Kittner, Steven J.

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

- Bellenguez, Céline, Bevan, Steve, Band, Gavin, Syme, Paul D., Malik, Rainer, Pera, Joanna, Norrving, Bo, Lemmens, Robin, Freeman, Colin, Schanz, Renata, James, Tom, Poole, Deborah, Gschwendtner, Andreas, Murphy, Lee, Segal, Helen, Cortellini, Lynelle, Cheng, Yu-Ching, Woo, Daniel, Nalls, Michael A., Müller-Myhsok, Bertram, Meisinger, Christa, Seedorf, Udo, Ross-Adams, Helen, Spencer, Chris C. A., Boonen, Steven, Wloch-Kopec, Dorota, Valant, Valerie, Slark, Julia, Furie, Karen, Delavaran, Hossein, Langford, Cordelia, Deloukas, Panos, Edkins, Sarah, Hunt, Sarah, Burgess, Annette I., Gray, Emma, Dronov, Serge, Peltonen, Leena, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Boncoraglio, Giorgio B., Parati, Eugenio A., Attia, John, Pirinen, Matti, Holliday, Elizabeth, Levi, Chris, Franzosi, Maria-Grazia, Goel, Anuj, Helgadottir, Anna, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Jackson, Caroline A., Duncanson, Audrey, Jankowski, Janusz, Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Viswanathan, Ananth C., Wood, Nicholas W., Traylor, Matthew, Worrall, Bradford B., Kittner, Steven J., Mitchell, Braxton D., Kissela, Brett, Meschia, James F., Thijs, Vincent, Lindgren, Arne, Macleod, Mary Joan, Slowik, Agnieszka, Walters, Matthew, Strange, Amy, Rosand, Jonathan, Sharma, Pankaj, Farrall, Martin, Sudlow, Cathie L. M., Rothwell, Peter M., Dichgans, Martin, Donnelly, Peter, Markus, Hugh S., Su, Zhan

Low-frequency and common genetic variation in ischemic stroke: the METASTROKE collaboration

- Malik, Rainer, Traylor, Matthew, Battey, Thomas W. K., Berger, Klaus, Boncoraglio, Giorgio B., Chauhan, Ganesh, Cheng, Yu-Ching, Chen, Wei-Min, Clarke, Robert, Cotlarciuc, Ioana, Debette, Stephanie, Falcone, Guido J., Pulit, Sara L., Levi, Christopher R., Bevan, Steve, Hopewell, Jemma C., Holliday, Elizabeth G., Zhao, Wei, Abrantes, Patricia, Amouyel, Philippe, Attia, John R.

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

- Kilarski, Laura L., Achterberg, Sefanja, Walters, Matthew, Worrall, Bradford B., Sale, Michele M., Algra, Ale, Kappelle, L. Jaap, Wijmenga, Cisca, Norrving, Bo, Sandling, Johanna K., Röennblom, Lars, Goris, An, Devan, William J., Franke, Andre, Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Holliday, Elizabeth G., Fornage, Myriam, Psaty, Bruce, Gretarsdottir, Solveig, Thorsteinsdottir, Unnar, Seshadri, Sudha, Traylor, Matthew, Mitchell, Braxton D., Kittner, Steven, Clarke, Robert, Hopewell, Jemma C., Bis, Joshua C., Boncoraglio, Giorgio B., Meschia, James, Ikram, M. Arfan, Hansen, Bjorn M., Montaner, Joan, Malik, Rainer, Thorleifsson, Gudmar, Stefanson, Kari, Rosand, Jonathan, de Bakker, Paul I. W., Farrall, Martin, Dichgans, Martin, Markus, Hugh S., Bevan, Steve, Lindgren, Arne, Pare, Guillame, Sharma, Pankaj, Slowik, Agniescka, Thijs, Vincent

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

- Malik, Rainer, Chauhan, Ganesh, Anderson, Christopher D., Chong, Michael, Adams, Hieab H. H., Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M., Benavente, Oscar R., Bevan, Steve, Traylor, Matthew, Holliday, Elizabeth G., Attia, John, Levi, Christopher R., Carrera, C, Carty, CL, Chasman, DI, Chen, W-M, Cole, JW, Correa, A, Cotlarciuc, I, Sargurupremraj, Muralidharan, Cruchaga, C, Danesh, J, de Bakker, PIW, DeStefano, AL, Den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gottesman, RF, Grewal, RP, Okada, Yukinori, Gudnason, V, Gustafsson, S, Haessler, J, Harris, TB, Hassan, A, Havulinna, AS, Heckbert, SR, Holliday, EG, Howard, G, Hsu, F-C, Mishra, Aniket, Hyacinth, HI, Ikram, MA, Ingelsson, E, Irvin, MR, Jian, X, Jiménez-Conde, J, Johnson, JA, Jukema, JW, Kanai, M, Keene, KL, Rutten-Jacobs, Loes, Kissela, BM, Kleindorfer, DO, Kooperberg, C, Kubo, M, Lange, LA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, J-M, Lemmens, R, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig

Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies

- Malik, Rainer, Bevan, Steve, de Stefano, Anita L., Fornage, Myriam, Psaty, Bruce M., Ikram, M. Afran, Launer, Lenore J., Van Duijn, Cornelia M., Sharma, Pankaj, Mitchell, Braxton D., Rosand, Jonathan, Meschia, James F., Nalls, Michael A., Levi, Christopher, Rothwell, Peter M., Sudlow, Cathie, Markus, Hugh S., Seshadri, Sudha, Dichgans, Martin, MD Wellcome Trust Case Control Consortium 2,, Holliday, Elizabeth G., Devan, William J., Cheng, Yu-Ching, Ibrahim-Verbaas, Carla A., Verhaaren, Benjamin F. J., Bis, Joshua C., Joon, Aron Y.