Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ehyl esters as norcantharidin analogues

Title: Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ehyl esters as norcantharidin analogues
Creator: Sauer, Benjamin; Gilbert, Jayne; Sakoff, Jennette A.; McCluskey, Adam
Relation: Letters in Drug Design & Discovery Vol. 6, Issue 1, p. 1-7
Relation: http://www.benthamscience.com/contents-JCode-LDDD-Vol-00000006-Iss-00000001.htm#3151404
Publisher: Bentham Science Publishers
Resource Type: journal article
Date: 2009
Description: A novel library of eighteen 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ethyl esters was generated in high yield in two steps from norcantharidin, a known protein phosphatase 1 and 2A inhibitor that displays good anticancer activity. Interestingly these analogues are bereft of anticancer and protein phosphatase activity, but possess the attributes needed for medicinal agents and could be used as scaffolds in other targets.
Subject: norcantharidin; Wittig reaction; protein phosphatase 1 and 2A; anticancer; drug design scaffold
Identifier: http://hdl.handle.net/1959.13/916719
Identifier: uon:8093
Identifier: ISSN:1570-1808
Language: eng
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