Luminal Ca²⁺ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains

Title: Luminal Ca²⁺ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains
Creator: Laver, Derek R.
Relation: European Biophysics Journal Vol. 39, Issue 1, p. 19-26
Publisher Link: http://dx.doi.org/10.1007/s00249-009-0417-1
Publisher: Springer
Resource Type: journal article
Date: 2009
Description: The ryanodine receptors form the calcium release channel in the membrane of the sarcoplasmic reticulum (SR, the main intracellular Ca²⁺ store). The importance of ryanodine receptors (RyRs) to cardiac pacemaking and rhythmicity is highlighted by more than 69 mutations, RyR mutations, which underlie arrhythmias and sudden cardiac death. Although most of these mutations lie in cytoplasmic domains, they all cause increased RyR activation by Ca²⁺ in the SR lumen. Presented here is a review of the mechanisms by which cytoplasmic domains of the RyR can determine luminal activation.
Subject: calcium release channels; cardiac muscle; calcium stores; sudden cardiac death; ryanodine receptor; bilayer
Identifier: uon:7011
Identifier: http://hdl.handle.net/1959.13/925322
Identifier: ISSN:0175-7571
Reviewed

		Thumbnail	File	Description	Size	Format