Control of homologous chromosome division in the mammalian oocyte

Title: Control of homologous chromosome division in the mammalian oocyte
Creator: Holt, Janet E.; Jones, Keith T.
Relation: Molecular Human Reproduction Vol. 15, Issue 3, p. 139-147
Publisher Link: http://dx.doi.org/10.1093/molehr/gap007
Publisher: Oxford University Press
Resource Type: journal article
Date: 2009
Description: Homologous chromosomes are segregated during the first meiotic division (meiosis I). Unfortunately, human oocytes are particularly susceptible to mis-segregation errors, so generating aneuploid, often non-viable, embryos. Here we review the cell biology of meiosis I and how homolog disjunction is regulated for mammalian oocytes. We focus on the activity of the anaphase-promoting complex/cyclosome (APC/C), which is responsible for timely degradation of the cohesin component, REC8 and the cyclin B regulatory subunit of maturation-promoting factor, both essential steps for meiosis I completion. In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs.
Subject: oocyte; homologs; meiosis; recombination; aneuploidy
Identifier: uon:6539
Identifier: http://hdl.handle.net/1959.13/804153
Identifier: ISSN:1360-9947
Language: eng
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